Sentences with phrase «gene regulatory networks»

The development of the animal body is regulated by large gene regulatory networks, which control the expression of gene sets that progressively generate developmental patterns in the animal body.
Development of the animal body plan was (and is) controlled by large and complex gene regulatory networks.
Together with long - standing collaborators Edward R. Dougherty (Texas A&M University) and Wei Zhang (M.D. Anderson Cancer Center), he co-developed the model class of probabilistic Boolean networks (PBNs), which was applied to the study of gene regulatory networks in cancer.
Then, methods for reconstructing gene regulatory networks from gene expression data will be looked.
EPFL scientists have now taken the first extensive look at a family of ~ 350 human proteins, showing that they establish a complex interplay with transposable elements to create largely human - specific gene regulatory networks.
«This co-evolution resulted in shaping human gene regulatory networks that are largely proper to our species or at least primate - restricted — the farther away in evolution, the fewer the similarities.»
Specifically, she investigates how plant organs are formed from stem cells, and how variation in the underlying gene regulatory networks can precisely modulate plant form.
How cellular gene regulatory networks (GRNs) respond to the morphogen, in a concentration - dependent manner, is a pivotal question in developmental biology.
Therapeutic agents able to directly affect gene regulatory networks that trigger inflammation and mucous - producing goblet cells would potentially be more efficient at slowing or stopping disease progression.
Molly Hammell Gene regulatory networks; integrated genomic analysis; bioinformatics; RNA biology; small RNAs
Marianne Bronner - Fraser — Caltech, Pasadena, USA Gene regulatory networks in neural crest evolution
It follows that evolution of body plans corresponded to adpative changes in the architecture of these developmental gene regulatory networks.
We studied design principle of gene regulatory networks subject to intrinsic noise and extrinsic perturbations.
Talks will discuss the origination of novel cell type gene regulatory networks, and cover the latest research into the evolution of cell type functional modules, such as protein complexes and larger macromolecular structures.
The long - term goals of my laboratory are to understand how alterations in the RB1 and TP53 tumor suppressor gene regulatory networks cause cancer.
We apply functional genomics methods such as ATAC - Seq and develop statistical methods to map gene regulatory networks in iPSC - derived neurons and predict the role of genetic variants for neurodevelopmental disorders.
The nuclear factor erythroid2 - related factor (Nrf2) is a genetic transcriptional factor that functions as the key controller of the redox homeostatic gene regulatory network.
Organismal characters are encoded in the genome by large gene regulatory networks (GRN).
Synthetic biology is a promising new tool to study the function and properties of gene regulatory networks (GRNs) by building them from first principles.
The next step for Asst Prof Xu and his team would be to uncover the gene regulatory network that has underpinned the successful adaptation of plants and their stem cells to cold environments.
Widespread contribution of transposable elements to the innovation of gene regulatory networks.
Two groups of researchers at the University of Massachusetts, Amherst, and the University of California, Davis, have found the gene regulatory networks that are responsible for the synthesis of the secondary cell wall components, cellulose, hemicellulose and lignin in the model plant Arabidopsis thaliana.
In fact, our present understanding of morphogenesis indicates that new phyla were not made by new genes but largely emerged through the rewiring of the gene regulatory networks (GRNs) of already existing genes (1).
By representing data in BioPAX, Pathway Commons is able to provide a detailed representation of a variety of biological concepts including: Biochemical reactions; gene regulatory networks; and genetic interactions; transport and catalysis events; and physical interactions involving proteins, DNA, RNA and small molecules and complexes.
Details that can be included are biochemical reactions; gene regulatory networks; genetic interactions; proteins, small molecules, DNA, RNA, complexes and their cellular locations; complex assembly and transport; post-translational protein modifications; citations; experimental evidence; and links to other databases e.g. protein sequence annotation.
They are defining the gene regulatory networks and signaling pathways underlying heart, nerve and limb regeneration, wound healing, immune responses to injury, stem cell function and the loss of regenerative capacity with age.
Using Drosophila as a model organism, his aims are to identify the gene regulatory networks that modulate neural stem cell properties during the course of development.
We focus on developing computational methods and tools for (a) analyzing large - scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks.
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