The development of the animal body is regulated by
large gene regulatory networks, which control the expression of gene sets that progressively generate developmental patterns in the animal body.
Together with long - standing collaborators Edward R. Dougherty (Texas A&M University) and Wei Zhang (M.D. Anderson Cancer Center), he co-developed the model class of probabilistic Boolean networks (PBNs), which was applied to the study
of gene regulatory networks in cancer.
EPFL scientists have now taken the first extensive look at a family of ~ 350 human proteins, showing that they establish a complex interplay with transposable elements to create largely human -
specific gene regulatory networks.
«This co-evolution resulted in shaping
human gene regulatory networks that are largely proper to our species or at least primate - restricted — the farther away in evolution, the fewer the similarities.»
Therapeutic agents able to directly
affect gene regulatory networks that trigger inflammation and mucous - producing goblet cells would potentially be more efficient at slowing or stopping disease progression.
Talks will discuss the origination of novel cell
type gene regulatory networks, and cover the latest research into the evolution of cell type functional modules, such as protein complexes and larger macromolecular structures.
We apply functional genomics methods such as ATAC - Seq and develop statistical methods to
map gene regulatory networks in iPSC - derived neurons and predict the role of genetic variants for neurodevelopmental disorders.
The nuclear factor erythroid2 - related factor (Nrf2) is a genetic transcriptional factor that functions as the key controller of the redox
homeostatic gene regulatory network.
Synthetic biology is a promising new tool to study the function and properties
of gene regulatory networks (GRNs) by building them from first principles.
The next step for Asst Prof Xu and his team would be to uncover
the gene regulatory network that has underpinned the successful adaptation of plants and their stem cells to cold environments.
Widespread contribution of transposable elements to the innovation of
gene regulatory networks.
Two groups of researchers at the University of Massachusetts, Amherst, and the University of California, Davis, have found
the gene regulatory networks that are responsible for the synthesis of the secondary cell wall components, cellulose, hemicellulose and lignin in the model plant Arabidopsis thaliana.
In fact, our present understanding of morphogenesis indicates that new phyla were not made by new genes but largely emerged through the rewiring of
the gene regulatory networks (GRNs) of already existing genes (1).
By representing data in BioPAX, Pathway Commons is able to provide a detailed representation of a variety of biological concepts including: Biochemical reactions;
gene regulatory networks; and genetic interactions; transport and catalysis events; and physical interactions involving proteins, DNA, RNA and small molecules and complexes.
Details that can be included are biochemical reactions;
gene regulatory networks; genetic interactions; proteins, small molecules, DNA, RNA, complexes and their cellular locations; complex assembly and transport; post-translational protein modifications; citations; experimental evidence; and links to other databases e.g. protein sequence annotation.
They are defining
the gene regulatory networks and signaling pathways underlying heart, nerve and limb regeneration, wound healing, immune responses to injury, stem cell function and the loss of regenerative capacity with age.
Using Drosophila as a model organism, his aims are to identify
the gene regulatory networks that modulate neural stem cell properties during the course of development.
We focus on developing computational methods and tools for (a) analyzing large - scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of
gene regulatory networks.