Sentences with phrase «gene regulatory sequences»

They also demonstrated significant advantages of editing gene regulatory sequences in their native location to uncover new functionalities that could lead to a better understanding of how control switches work to turn genes on and off in the body.

Not exact matches

More recently, it has become clear that slight variations in the regulatory sequences that determine when a gene is switched on,...

Fortunately only about 3 percent of that is actual genetic information that gets translated into proteins; the rest is regulatory sequences, old, nonfunctioning genes, or outright nonsense.

A chromosome is, minimally, a very long, continuous piece of DNA, which contains many genes, regulatory elements and other intervening nucleotide sequences.

Another experiment looked at Arabidopsis containing a reporter gene called GUS that was fused to the regulatory sequences of the cytokinin receptor genes.

The problem is that they insert genes at random locations in the genome, as well as inserting regulatory sequences that can sometimes activate nearby genes and trigger cancer.

These still insert genes randomly, but can be modified to disable some regulatory sequences.

The findings are especially important as they highlight the discovery of a regulatory sequence, termed the J element, that controls class I gene expression of many more genes than the counterparts that regulate class II gene expression.

In some diseases, the problem lies within the sequence of a gene, but defects in regulatory regions found elsewhere in the genome can be equally dangerous and much harder to understand.

«As we enter an era where the DNA sequences of entire human populations are increasingly accessible, we would like to know the functional significance of changes in gene regulatory regions.»

Molecular studies of Hox - regulated target genes suggest that these changes occur through accumulation of mutations in regulatory DNA sequences.

Most importantly, this body of work has uncovered some of the first direct evidence for the central role of changes in gene cis - regulatory sequences in the evolution of body plans and body parts and in the origin of new structures and pattern elements.

Details that can be included are biochemical reactions; gene regulatory networks; genetic interactions; proteins, small molecules, DNA, RNA, complexes and their cellular locations; complex assembly and transport; post-translational protein modifications; citations; experimental evidence; and links to other databases e.g. protein sequence annotation.

The National Human Genome Research Institute, part of the National Institutes of Health, has awarded $ 9.1 million over four years to a research team led by the University of Chicago to identify all regulatory elements, the DNA sequences that control when and where specific genes get turned on or off, in the fruit fly genome.

However, several genetic mechanisms — including the evolution of protein - coding sequences and gene duplication, as well as the evolution of regulatory sequences — are sources of variation in all species and contribute to organismal adaptation.

We sequenced exons and regulatory elements for 608 genes implicated in OCD in humans and two animal models, mouse and dog.

Lower sequence coverage (survey sequencing) of related species can yield a wealth of information about gene content and putative regulatory elements.

Many of these sequences are non-coding, such as regulatory signals, structural sites and RNA genes.

The resulting datasets of regulatory genomic sequence will provide a valuable resource in determining how non-coding DNA sequence variation may impact an individual's capacity to drive appropriate gene expression.

Dr. Loftus» current research integrates the identification of these types of epigenetic modifications that mark the melanocyte regulatory genomic landscape with regulatory protein and transcription factor chromatin - binding domains, thus defining groups of non-coding DNA sequences utilized in the control of melanocyte gene expression.

Many different classes of regulatory genes share a common DNA sequence known as the homeobox, which predates the origin of animals.

But rather than changes in doublesex itself, these studies revealed changes in downstream targets of dsx, via changes to specific DNA sequences to which DSX protein binds in the cis - regulatory regions of the bric - a-brac and desatF genes and affecting sex differences in abdominal pigmentation and pheromone production.

Instead, the disease - linked genetic changes appear to occur in vast tracts of sequence between genes where ENCODE has identified many regulatory sites.

Such patterns of rapid divergence are not only prevalent among morphological traits like male genitalia, but also extend to the molecular level, including DNA sequences, the expression profiles of sex - biased reproductive genes and regulatory pathways underlying sex determination.

The majority of these loci correlate with non-coding genomic regions, underscoring that differences in DNA sequences located within melanocyte gene regulatory elements significantly contribute to melanocyte biology and disease.

In many imprinted genes, regulatory sequence elements have been identified that are methylated on one of the parental chromosomes only.

More than half of mammalian genes generate multiple messenger RNA isoforms that differ in their 3 ′ untranslated regions (3 ′ UTRs) and therefore in regulatory sequences, often associated with cell proliferation and cancer; however, the mechanisms coordinating alternative 3 ′ - UTR processing for specific mRNA populations remain poorly defined.

At present we are engineering regulatory sequences to direct gene expression selectively to target cells and tissues in the CanEuCre / Pleiades Promoter Project.

Genome editing technology enables precise modification of individual protein coding genes, as well as noncoding regulatory sequences, enabling the elucidation of functional effects in human disease relevant cellular systems.

The Wasserman laboratory focuses on the creation, evaluation and application of computational methods for the analysis of genome sequences, with international strength in the study of cis - regulatory elements regulating gene expression.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

Large - scale DNA sequencing of a variety of organisms has led to a detailed annotation of genes and regulatory elements dispersed throughout their genomes.

We have demonstrated that the regulatory regions of housekeeping and tissue specific genes have differential chromatin architecture with respect to S / MAR binding, nucleosome positioning potential and repetitive sequences.

Cell identity is specified by the coordinated action of transcription factors, which bind to specific DNA regulatory sequences and turn gene expression on.

In relation to the association of infant attachment with a promoter polymorphism of the serotonin transporter gene, we have mentioned that gene expression may be affected by variation in the DNA sequence of the regulatory region of the gene.