Sentences with phrase «gene regulatory switches»
This confirmed that the gene regulatory switch is highly specific to one cell type, monocytes and that tumor cell invasion in the absence of this population had nothing to do with deregulated macrophage activity.
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More recently, it has become clear that slight variations in the regulatory sequences that determine when a gene is switched on,...
Harris and Peter Ratcliffe, also at the IMM, discovered the genetic switches, which they call «hypoxia - responsive elements» (HREs), in segments of DNA known as regulatory genes.
With chronically infected mice as their model, the researchers used a new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA involved in switching genes on and off — in the animals» exhausted and functional CD8 + T cells.
«The complexity of our biology resides not in the number of our genes but in the regulatory switches,» Eric Green, director of the National Human Genome Research Institute and collaborator on the ENCODE project, said in a press briefing September 5.
They also demonstrated significant advantages of editing gene regulatory sequences in their native location to uncover new functionalities that could lead to a better understanding of how control switches work to turn genes on and off in the body.
The team studied the genomes of almost 8,000 child and parent trios, focusing on genes that coded for proteins as well as non-coding parts of the genome that control the switching on and off of genes, known as regulatory elements.
The advances even point to strategies for exploiting these regulatory elements to treat disease, by switching off disease genes and turning up the activity of healthy ones.
What makes a horse different from a tiger, a mouse and a walrus is the set of regulatory switches in the DNA that dictate where, when and for how long those genes are active.
Developmental regulation proceeds through the sequential activation of a series of regulatory switches that in turn activate networks of other genes.
One suggestion that has generated considerable interest is the possibility that the risk polymorphisms located far from genes could function as gene regulatory elements or «switches» that regulate the expression of genes.
Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch.
There may be genes that influence where white shows up or regulatory DNA that switches those genes on or off.