Sentences with phrase «gene selection approaches»
«Using innovative data normalization and gene selection approaches, we combined the statistical power of multiple genomic studies and masked their variability and batch effects to identify robust early diagnostic biomarkers of pancreatic cancer,» said first author Manoj Bhasin, PhD, Co-Director of BIDMC's Genomics, Proteomics, Bioinformatics and Systems Biology Center and Assistant Professor of Medicine at HMS.
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A companion paper published in BMC Evolutionary Biology by colleagues at the EPA lab in Narragansett, RI, that used a «candidate gene scan» approach — examining SNPs from 42 genes associated with the AHR pathway — also identified AHR2 as a gene that appears to be under selection and is likely to be involved in the resistance.
Ensuring appropriate target gene selection and maintaining a diversified pre-clinical engine are key aspects of our strategic approach.
Despite exploiting signatures displaying different statistical properties, these methods individually detected genes previously identified as undergoing selection in domesticated horses, such as KITLG (9) and melanocortin 1 receptor (MC1R)(40), providing important validation of the approach as a whole.
To ask whether genes lying within regions of differentiation were significantly more affected by positive selection than the genome - wide average, we used two approaches.
A common approach is to sort genes by gene ontology (GO)[9] category and speculate on their likely function, involvement in potential pathways, and reasons for being under selection.
In human medicine, the identity of cytogenetic aberrations has been shown to also assist in the localization of cancer - associated genes and even selection of the most appropriate therapeutic approach.