Sentences with phrase «gene sequences into»

Translating the differences between gene sequences into a date for their divergence, the researchers conclude that the various forms of RRM2P4 last shared a common ancestor about two million years ago — around when H. erectus migrated from Africa into Asia.

«Decoding the genome's cryptic language: New tool to map RNA - DNA interactions could help researchers translate gene sequences into functions.»

Not exact matches

The researches found that the transgene was inserted into an active region of the genome, thereby disrupting the coding sequence and ultimately the function of the plants own OsAux1 gene.

Blasting GM DNA into a plant arbitrarily and out of a sequence of genes that has evolved over hundreds of millions of years, in a manner aimed to optimise the functioning of an organism, is risky and unpredictable, and bound to destabilise the biochemistry of the plant.

When looking into mechanisms that might affect the levels of SMN protein in neurons, the researchers scanned a genomic database called the UCSC Genome Browser and identified two genetic sequences that matched the opposite DNA strand of the SMN gene.

A transgenic mouse — one with foreign genes swapped into its DNA — poses with its own gene sequence at Harvard Medical School.

Then, using the CRISPR - Cas gene - editing tool, they spliced sequences corresponding to individual video pixels into the genome.

The team found that humans are equipped with tiny differences in a particular regulator of gene activity, dubbed HARE5, that when introduced into a mouse embryo, led to a 12 % bigger brain than in the embryos treated with the HARE5 sequence from chimpanzees.

The Tetrahymena intervening sequence (IVS) has been inserted into the gene for the alpha - donor fragment of beta - galactosidase in a recombinant plasmid.

When Blakely's team spliced the DNA sequence that encodes the relevant fly amino acid into the mouse serotonin transporter gene, the mice now made a transporter that was 80 times less sensitive to cocaine, while allowing the transporter to function completely normally.

To build a family tree for the orchids, the scientists sequenced genes in the green structures, called chloroplasts, in which plants transform solar energy into sugar.

Gene sequencing is also allowing Jackson and Seed to track down the sources of microbes, both benign and malignant, that find their way into the newborns in the study.

«By inserting the new sequence into the DNA, perhaps they are altering the gene in some other way,» he says.

You type the DNA sequence of your gene into a database, and then you sit and you wait.

They thrive in bodily fluids and tend to get copied several times into host gene sequences, which can wreak genetic havoc and sometimes lead to cancer.

But critics warn that genetic engineering has a dark side too, and could lead to designer babies or the release of dangerous DNA sequences into the gene pool, with dire environmental consequences.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

The gene - editing success appears to be largely due to one procedural change: The researchers introduced the editing system — the enzyme Cas9 and a guide RNA sequence that helps the editing machinery find its target — at the same time they injected the mutation - laden sperm into a healthy egg in the lab.

They enable molecular biologists and geneticists to selectively chop DNA into pieces, which can then be assembled into new versions of the gene, inserted into the genomes of other organisms, or sequenced as part of an effort to map an organism's genetic material.

For most known genes this «messenger» or mRNA is then shuttled off to a ribosome of a cell where its translation into a protein sequence occurs.

To deliver the healthy gene, the team inserted it into an engineered virus called adeno - associated virus 1, or AAV1, together with a promoter — a genetic sequence that turns the gene on only in certain sensory cells of the inner ear known as hair cells.

Fortunately only about 3 percent of that is actual genetic information that gets translated into proteins; the rest is regulatory sequences, old, nonfunctioning genes, or outright nonsense.

As when he worked on the human genome, Venter is relying on a radical technique called shotgun sequencing: He chops up vast amounts of DNA into tiny pieces and then uses sophisticated computer analyzers to piece them back together into intelligible genes and chromosomes.

By characterising the DNA sequence of these individuals, the project gained insight into the contribution of rare variants to a broad range of disease scenarios, and discovered new genetic variants and genes underpinning disease risk.

The team looked at the DNA sequence of mitochondrial cytochrome b gene to gain more precise genetic information and gain insight into the history of the animals» migration routes.

Using next - generation RNA sequencing and other advanced technologies, the researchers identified a previously unknown gene involved in betalain synthesis and revealed which biochemical reactions plants use to convert the amino acid tyrosine into betalains.

After the fly is defrosted in a sterile environment, the various parts are separated, crushed and then put into a gene sequencing machine.

When they sequenced ribosomal genes to identify the bacteria within each sample, the researchers found that the samples fell again into two groups.

Researchers from various institutions are increasingly bringing troves of DNA sequences into huge gene banks in hopes of tackling diseases.

Previous efforts to sequence preserved mammoth DNA were error - prone or yielded insights into only a limited number of genes.

Sequencing the genome and assessing gene activity in various tissues in the tsetse fly led to new insights into its biology and the control of parasitic diseases transmitted by this insect.

To do this, they incorporated the gene sequence of each receptor into cultured cells and then probed the cells to determine if they were activated by one or more of 25 different bitter - tasting chemicals.

They took one person's DNA (the molecule that contains all genes), chopped it up into little pieces and determined the sequence of base pairs in each piece.

In flu surveillance, researchers look primarily for the genes encoding the virus's surface proteins, hemagglutinin and neuraminidase; if they sequence the so - called internal genes as well, they might detect new genes slipping into human virus strains in the run - up to a pandemic, they say.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

During this crucial step, messenger RNA (mRNA), which is a RNA copy of a gene's recipe for a protein, is translated by the cell's ribosome into the sequence of amino acids that will make up a newly synthesized protein.

Using «homologous recombination,» CRISPR can also be used to insert new DNA sequences or even whole genes into the genome in a precise way.

When the promoter upstream of the GFP gene was activated, the RNA polymerase ran headfirst into the termination sequence, stopped reading the DNA, and didn't produce the fluorescent protein.

siRNAs are designed by taking short sequences of the gene to be targeted and converting them into double - stranded RNA.

Working with French composer Richard Krüll, the pair turned the complete nucleotide sequences of several microbe genes into compositions based on DNA bases: A (adenosine), C (cytosine), G (guanine), and Thymine (which they have translated to «Re,» or D).

Is it appropriate to stop at observable traits, such as leaf size, or to dig into individual gene sequences?

He says HGS was getting «diminishing returns» from its investment in TIGR since Venter had steered his outfit into sequencing organisms of little medical importance, and into human genome sequencing, also of limited value for a company like HGS that is interested in genes as drug targets (not untranslated DNA that makes up most of the genome).

By isolating strands of complementary DNA (cDNA) that fit together with mRNA, researchers can figure out what sequence was just translated into mRNA — that is, they can get a read on an expressed gene.

Because some mutations are present in the DNA but the gene is not made into RNA and protein, the researchers used RNA sequencing to identify mutations that caused the production of a mutated RNA, which is then normally translated into a protein.

After that, the researchers back - translate the amino acid sequence into a genetic sequence, buy the DNA base pairs to build the gene spelled out by that sequence, and then turn the gene loose in bacteria or yeast that have been programmed to manufacture the protein.

The ZFNs targeting either the cxcr4 or ccr5 genes were linked via a 2A peptide sequence and cloned into the pAdEasy - 1 / F35 vector under control of the CMV TetO promoter, and the Ad5 / F35 virus for each construct was generated using TREx 293T cells as described [33].

After the sections of DNA sequence have been assembled into a complete genome sequence we need to identify where the genes and key features are, but how do we do this?

Reykjavik, ICELAND, 12 October 2011 — deCODE genetics today announced that it has entered into a research collaboration with Pfizer Inc., the objective of which is to discover sequence variants associated with specific clinical phenotypes related to Systemic Lupus Erythematosis by utilizing deCODE's expertise in gene discovery.

When zinc hooks up with a gene - controlling protein, it forms «zinc finger proteins» - so called because they can poke into the tight groove between the two strands of DNA and touch the sequence they're made for.

April 2012 - New research: Illuminating embryonic stem cells Collaboration between two EU funded projects «Heroic» and «EuroSyStem», has provided new insights into embryonic stem cells The teams used next generation sequencing technology to examine two key properties of the cells that influence their identity and behaviour: gene expression and gene regulation.