Sentences with phrase «gene sequencing provides»

For instance, services like 23andMe use genotyping to zoom in on a selection of important DNA base pairs, while specific gene sequencing provides data on particular bases.

Gene sequencing provides an organism's genome sequence, but gene expression profiling reveals where and when in the body certain genes are active.

Not exact matches

This dataset contains millions of genomic sequences from a diverse set of rice varieties that, when combined with phenotyping observations, gene expression, and other information, provides an important step in establishing gene - trait associations, building predictive models, and applying these models to breeding.

Which genes are activated and which are turned off is in part determined by a second tier of information which is superimposed on the nucleotide sequences that provide the blueprints for protein synthesis.

Brains of individuals who died with Huntington's, Parkinson's or no neurological condition were analyzed using sequencing technology that provides a data readout of the activity of all genes in the genome.

On the other hand, by deciding that an EST sequence does not provide an adequate written description of a claim directed to «a gene,» the PTO has preserved the possibility for a gene itself to be patented once its full - length sequence is determined.

The sequences provide researchers access to 96 percent of all peanut genes and provide the DNA map needed to more quickly identify and genetically tag genes that confer desirable traits, such as drought - and disease - resistance.

They also ruled out other possibilities, including the gene spontaneously mutating back to the normal form, the existence of more than two copies of the hothead gene, or closely related DNA sequences providing a template for repairs.

These tags are detected and measured using a sensitive DNA analysis technique known as massive, parallel sequencing, providing a quantitative readout of the gene's activity levels.

A comprehensive DNA sequencing of pancreatic cancer cases revealed not only a plethora of damaged genes, but potential diagnostic biomarkers that could help identify those with longer or shorter survival, and provide opportunity for new therapeutic interventions.

The BBSRC - funded ARK - Genomics facility — which is part of Edinburgh Genomics at the University of Edinburgh — provided a substantial body of sequence data, including information on which genes are expressed in a spectrum of 40 different tissues.

Thus transformation provides an in vivo assay for the functional role of DNA sequence organization about specific genes.

In the September issue of G3, Cuomo et al. unveil the first whole - genome sequence of a clinical sample of C. krusei, providing leads on genes that may be important for the species» fluconazole resistance.

For over half (54 %) of the 39 companies, it was impossible to find out which gene sequences and variants would be tested, because this information wasn't provided.

In the meantime, Boeke says Sleeping Beauty could provide a new and better way to create mutants to study embryonic development, since the inactivated gene can be «tagged» using a short DNA sequence inserted by the transposon.

The discovery, the product of a multiyear effort to provide a high - quality full genome map of the oil palm plant and to scour the sequence for genes of importance to both science and industry, has major implications for agriculture and the environment.

«This new technology will allow us to sequence all the genes in the genome and obtain a genetic portrait of the children more quickly to know which disease they suffer from and to provide treatment, if available, or when it becomes available.»

The genes in the foreign DNA sequences were also shown to be active in sweet potato, which can indicate that they provide a positive characteristic which was selected for by the farmers during domestication.

According to Dr. Wong, «This combined strategy provides us with a new tool for reliable molecular analysis of any genes containing multiple copies of highly homologous sequences and should improve the positive finding rate for patients with Lynch syndrome if the PMS2 gene is suspected to be defective.

High throughput genome sequencing and quantitative image analysis provide evolution, metabolic, and interaction data to build community metabolome maps, taxa / gene networks, and spatial ecosystem models.

The atlas now also includes RNA transcript data for 27 of these organ - specific tissues using next generation sequencing, providing a tissue distribution map of both protein and gene expression.

«Their duplicated hybrid genome architectures provide these nematodes with multi-copy genes showing diverged sequence and expression patterns where their sexual relatives have very closely related alleles,» says Danchin.

Oligonucleotide probe selection and synthesis — The 1,178 genes comprising the Falk Center for Molecular Therapeutics (FCMT) Rat CNS microarray were compiled from currently available NCBI / EMBL / TIGR rat sequence databases and commercially available central nervous system (CNS) microarrays (Affymetrix, Santa Clara, CA) and provided representation from greater than 90 % of the major gene ontological categories [47].

The advancement of the Cas9 - based platform for screening and validation will help further the development of new therapeutic products, and Caribou's CRISPR - Cas9 technology can utilize guide RNAs specific for unique sequences and target a gene at numerous sites and therefore provide enhanced specificity.

James Giovannoni generated the gene expression data through RNA - sequencing and Lukas Mueller provided additional analysis to confirm the quality of the genome assembly.

The goals of the project are as follows: (1) to shotgun sequence the C. murisgenome to 8X coverage; (2) to sequence 20,000 clones from a C. muris cDNA library to provide gene prediction training and verification data; and (3) to manually annotate the C. muris genome sequence in comparison with the genome sequence data for C. parvum and C. hominis.

April 2012 - New research: Illuminating embryonic stem cells Collaboration between two EU funded projects «Heroic» and «EuroSyStem», has provided new insights into embryonic stem cells The teams used next generation sequencing technology to examine two key properties of the cells that influence their identity and behaviour: gene expression and gene regulation.

The provided sequence of the designer Tat Gene was inserted between the Hindlll and EcoR1 sites of the pUC18 vector.

deCODE has identified key variations in the sequence of the genome conferring increased risk of major public health challenges from cardiovascular disease to cancer, and employs its gene discovery engine to develop DNA - based tests to assess individual risk of common diseases; to license its tests and intellectual property to partners; and to provide comprehensive, leading - edge contract services to companies and research institutions around the globe.

Previous studies have published bay scallop expressed sequence tags [23, 24] and transcriptome sequences [17], which provided valuable resources for gene cloning.

«The human genome sequence provided a blueprint of all the protein - coding genes in the human genome for the first time,» reveals Jan Ellenberg, Head of the Cell Biology and Biophysics Unit at EMBL Heidelberg, «this changed how we go about studying protein function.»

Insertional mutagenesis with a single P element provides a powerful approach to obtaining mutations in silent genes when carried out in the context of whole genome sequencing.

She has pioneered the intergration of large - scale genome and transcriptome sequencing data to understand how genetic variation affects gene expression, providing insight to cellular mechanisms underlying genetic risk for disease.

Careful manual annotation of the human reference sequence provides a solid basis for the identification of disease - associated genes.

The presence of such sequences could provide organisms with a way to modify their gene expression without altering the actual coding sequence of genes.

The advent of RNA - seq technology, in conjunction with full genome sequencing, provides a method for the unbiased characterization of genes regulated by infection in almost any species that can be manipulated in the laboratory.

To provide access to the gene sequences of the tomato and related species, Boyce Thompson Institute scientist Lukas Mueller and his team have created an interactive website (www.solgenomics.net).

The resulting datasets of regulatory genomic sequence will provide a valuable resource in determining how non-coding DNA sequence variation may impact an individual's capacity to drive appropriate gene expression.

Sequencing the zebrafish genome provided evidence of more than 26,000 protein - coding genes, the largest set of any vertebrate sequenced so far.

Full - genome sequencing of affected individuals and their parents provides a powerful alternative strategy for gene discovery.

Conclusions Seqping provides researchers a seamless pipeline to train species - specific HMMs and predict genes in newly sequenced or less - studied genomes.

The Genomics Core is a recent addition to the CCF / LRI Core services community and will provide research groups access to state - of - the - art genomics capabilities (sequencing, genotyping and gene expression arrays).

The high conservation of the protein coding sequence for this LGT among Lepidoptera that have diverged over 65 — 145 million years ago (MYA) and evidence of its expression, provides strong support that this gene is functional.

The explosion in the number of newly sequenced genomes provides opportunities to identify and characterize examples of these lateral gene transfer events, and to assess their role in the evolution of new genes.

We sequenced at sufficient depth to produce new, extended receptor gene models for 913 (73.1 %) OR and 246 (45.9 %) VR genes (the models and their sequences are provided in Datasets S4, S5, S6, S7).

The sequencing studies, reported in the December 16, 1999, issue of the journal Nature, provide a great deal of new information about chromosome structure, evolution, and gene organization in plants.

This dataset contains millions of genomic sequences from a diverse set of rice varieties that, when combined with phenotyping observations, gene expression, and other information, provides an important step in establishing gene - trait associations, building predictive models, and applying these models to breeding.

Whilst a number of genes have been identified previously from investigation of families with Mendelian inheritance patterns, sequencing the DNA from large cohorts of individuals with congenital heart disease is now providing fresh insights into the genetics of these conditions.

Here we report that at least 96 % of the protein - coding genes have been identified, as assessed by multi-species comparative sequence analysis, and provide evidence for the presence of further, otherwise unsupported exons / genes.

The resource provides services including: processing of the samples (cells or tissues) to make high quality chromatin for ChIP, ChIP with a set of validated antibodies for histone marks (Promoter marks: H3K4me3 and H3K27me3, Enhancer marks: H3K4me1 and H3K27ac, Gene body marks for transcription activity: H3K36me3 and H3K79me2, and Heterochromatin mark: H3K9me3), ChIP with investigator preferred custom antibodies, and library preparation from ChIP DNA and multi-plexing for high - throughput DNA sequencing.