Sentences with phrase «gene sets»

The development of the animal body is regulated by large gene regulatory networks, which control the expression of gene sets that progressively generate developmental patterns in the animal body.

The scientists were thus for the first time able to identify gene sets responsible for steering specific memory processes.

All the babies start with the same gene set: They're either all boys or all girls, and they'll look alike.

But it's associated with liver problems in rare individuals carrying another specific gene set.

This running sum increased when a gene defined as belonging to a particular gene set was encountered; otherwise, the sum decreased.

The results showed that they chose the ones with a certain gene set that were very different from their own, making them genetically compatible.

The method identifies gene sets that show evidence for positive selection in comparison with matched controls, and thus highlights genes for further functional studies.

As revealed by gene set enrichment analysis, the MAPK pathway was inactivated in the combination treatment group compared with the untreated group.

GoMINER [33,34], Gene Set Enrichment Analysis (GSEA)[35] and Human Interactome Mapping (HiMAP) were then applied to identify those gene families that showed differential expression during hypoxia or recovery.

They are gearing up to publish their first «release» of the official gene set as a collaborative paper, which will be a vital resource in finding a way to stop the psyllid from spreading the citrus greening pathogen.

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

A new meta - analysis suggests that low expression levels of 10 related gene sets responsible for mitochondrial machinery play an important role in this disorder — all previously unlinked to Parkinson's.

SAP domain - dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients.

The second tool, SuperExactTest, establishes the very first theoretical framework for assessing the statistical significance of multi-set intersections and enables users to compare very large sets of data, such as gene sets produced from genome - wide association studies (GWAS) and differential expression analysis.

Heterogeneity between males and females was identified in gene sets associated with T2DM in humans (189), 5 pathways were identified in the male group and 13 in the female group, with only 3 pathways overlapping.

Annotation release 1.0 was generated by comparing and merging gene sets produced independently by VectorBase and JCVI.

Many of the RNA - Seq generated models appeared to be fragments and we needed to remove them by filtering our results before we could include our findings in the Ensembl gene set.

To confirm that early differentiation pattern exhibited in the V+S + fraction was indeed an early state in PrEn differentiation, rather than a metastable pro-differentiation state similar to that described for the Oct4 positive populations that do not express Nanog, Rex1, or Stella [8]--[11], we examined the behaviour of gene sets representing other lineages in our data set (Figure 3C and Figure S3).

With the substantial increase in predicted gene number and gene quality obtained with the OGSv2 gene set, it is clear that an updated annotation of infection responsive genes would be valuable.

Analysis of the Amphimedon gene set reveals marked conservation of gene structure (intron phase and position) and genome organization (synteny) relative to other animals (Supplementary Notes 5 and 6).

When ants are born with two of the same sex determination gene sets, they become sterile diploid males, even if they should develop as females.

«BinoX works so well thanks to the high density of the FunCoup networks, which makes it possible to find many functional network links between gene sets, even if they have no shared genes.

«Ten years ago, people would have laughed at the idea of bacteria with such a small gene set.»

Surprisingly, these conserved gene sets were also associated with several other biological traits, which evolved multiple times in ants, such as number of queens in a colony, whether an ant species is invasive or not, and the degree of worker sterility.

Following up on that observation, Guccione and his colleagues from A * STAR decided to investigate which gene sets are turned on by MYC in mouse models of lymphoma.

Interestingly, so - called circadian genes, whose expressions increase and decrease over a 24 - hour cycle, are overrepresented in the prediction gene sets, demonstrating an intrinsic link between circadian genes in the brain and mood change - like behavior.

Through both automated and manual approaches, the team curated a refined collection of MSigDB gene sets that reduce redundancy and produce more robust analyses.

Because of the usefulness of this information, we set ourselves the goals of constructing a zebrafish gene set based on RNA - Seq alone and then identifying the highest quality models.

Mixed - species RNAseq analysis of human lymphoma cells adhering to mouse stromal cells identifies a core gene set that is also differentially expressed in the lymph node microenvironment of mantle cell lymphoma and chronic lymphocytic leukemia patients

Genes encoding proteins of unknown function constitute 28 % of the essential protein - coding genes set.

A: Genes contributing to the significant enrichment scores of GSEA for gene sets involved in oxidative phosphorylation (OXPHOS) divided by the different complexes, pyruvate metabolism, and Toll - like receptor signaling pathway in adipose tissue of diabetic vs. nondiabetic co-twins.

We applied gene set enrichment analysis (GSEA)(23) to expression array data using KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways.

Annotation release 1.0 was derived by comparing and merging gene sets generated independently by VectorBase and TIGR.

Automated and manual annotation to produce the GENCODE reference gene set (v7) of protein - coding genes, pseudogenes, and non-coding RNAs.

Fisher's exact test as implemented in R66 was run to test for enrichment or depletion of numbers of gene families for each molecular function category in the novel versus ancestral gene sets.