Sentences with phrase «gene sets associated»

Heterogeneity between males and females was identified in gene sets associated with T2DM in humans (189), 5 pathways were identified in the male group and 13 in the female group, with only 3 pathways overlapping.

«And this approach could be used in conjunction with high - throughput screening techniques to identify gene sets associated with problems such as multidrug resistance or benefits, like those related to probiotics.»

Not exact matches

At last year's Brainstorm Health conference in San Diego, Bergh found himself sitting at dinner with Othman Laraki, the cofounder and CEO of Color Genomics — a company that extracts the DNA from a customer's submitted saliva sample and then looks for a set number of gene mutations known to be associated with increased risk for developing certain hereditary cancers or heart conditions (depending on the test).

But it's associated with liver problems in rare individuals carrying another specific gene set.

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

The study identifies a wide set of genes — previously associated with complex structures in higher animals — which were supposedly absent in sponges.

A different set of genes have been associated with hemorrhagic stroke (bleeding into the brain).

«If you look at a set of lung cancer patients, like we did in the paper, who develop brain metastases, they all have those two genes in their primary lung cancer,» said Sheila Singh, the study's supervisor, associate professor at the Michael G. DeGroote School of Medicine, scientist with the Stem Cell and Cancer Research Institute at McMaster University and neurosurgeon at McMaster Children's Hospital.

In January 2016, a landmark study in Nature from the Broad Institute in Cambridge, Massachusetts, reported that a set of genes associated with schizophrenia can contribute to synaptic pruning.

Dangl intends to greatly expand his efforts to understand which plant genes are involved in setting up microbe communities associated with roots.

«These people are born with a broken gene and it sets them up for leukemia,» says Chris Porter, MD, investigator at the CU Cancer Center and associate professor in the Department of Pediatrics at the CU School of Medicine.

«We set out to find out about human genes that are implicated in the regulation of the gut microbiome, and we found some that are,» says senior author Ruth Ley, an Associate Professor in the Department of Microbiology at Cornell University and the study's senior author.

Surprisingly, these conserved gene sets were also associated with several other biological traits, which evolved multiple times in ants, such as number of queens in a colony, whether an ant species is invasive or not, and the degree of worker sterility.

In this study, the parallels between the species were established because almost all of the sets of genes the team identified were associated with either queen or worker traits.

Many cluster around sets of genes associated with growth, including 21 variants found in or near genes that regulate the building of bone.

GOMiner — To provide additional statistical stringency to the identification of potential targets, we then analyzed the data sets generated by the SAM - RS analysis of the microarray data for hypoxia - associated coregulation of multiple, functionally related genes.

Sadly only a few of these are associated with an sufficiently extensive set of evidence such that responsible human trials are an immediate possibility: myostatin knockout for muscle growth and telomerase gene therapies to offset some of the declines of aging.

Genes involved in redox activity («oxidoreductase activity» GO: 0016491; P = 7.46 e − 04), those associated with responses to various stimuli, e.g., phytohormones («response to hormone» GO: 0009725; P = 2.96 e − 06), and «meristem determinacy» (GO: 0010022; P = 7.74 e − 05) were also overrepresented in the DE gene set (Table 2; Supplemental Figure 8 and Supplemental Data Set set (Table 2; Supplemental Figure 8 and Supplemental Data Set Set 5).

«What makes it particularly interesting is that the region we can show is associated with protection happens to be right up against a set of genes we know are related to how malaria invades the red blood cell,» study author Dominic Kwiatkowski of the Wellcome Trust Sanger Institute and the Wellcome Trust Centre for Human Genetics told The Post.

ONE - PARENT SAMPLE SET PARENTAL GUIDANCE RULES: Maternally methylated (red dots) and paternally methylated (blue dots) regions across the human autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expressed.

To evaluate whether altered expression of the ABL genes is associated with breast cancer progression and metastasis, we examined the expression of ABL1 and ABL2 in normal and invasive breast tumor specimens using published TCGA (The Cancer Genome Atlas) data sets (14 — 16).

When the skin cell sample is taken from someone with a specific disease, those iPS cells contain a complete set of the genes associated with the illness, and disease models can be developed to facilitate research and drug discovery.

One of the rare variant burden genes, TIMP3, was previously associated with Sorsby's fundus dystrophy, a rare disease similar to AMD but with earlier on set and Mendelian inheritance.

Whitehead Institute researchers have found that an ancient, highly conserved cell survival factor drives expression of a specific set of genes that is strongly associated with metastasis and death in patients with breast, colon, and lung cancers.

Most people understand it to be a term associated with genes, genetics, or DNA; the set of instructions which lie at the heart of every cell.

We found that the V+S + population expressed sets of genes that fell into major functional categories that were associated with «Cell adhesion» and «Cell migration.»

Interestingly, the most commonly mutated set of genes were those involved in epigenetic modification (25 % of tumors) followed by transcriptional regulators and MAP kinase - associated genes (12 - 15 %).

The Salk researchers, which include co-first authors Mo Li and Keiichiro Suzuki, both research associates in Belmonte's laboratory, set out to devise a safe method to use iPSCs to correct the HBB gene in patients who have defective copies of the gene.

Fitness -, virulence - associated genome regions, and CRISPR / CAS (clustered regularly interspaced short palindromic repeats / CRISPR associated sequence) arrays of these STEC O156: H25 and O182: H25 isolates were highly similar, and identical genomic integration sites for the stx converting bacteriophages and the core LEE, identical Shiga toxin converting bacteriophage genes for stx1a, identical complete LEE loci, and identical sets of chemotaxis and flagellar genes were identified.

TCGA researchers also established how sets of genes are expressed in a fashion that can predict patient survival - identifying patterns for 108 genes associated with poor survival and 85 genes associated with better survival.

In Activity 1, students identify the locations on chromosomes of genes involved in cancer, using a set of 139 «Cancer Gene Cards» and associated posters.

Mutations in a variety of ADAMTS genes have been associated with a diverse set of human diseases including Ehlers - Danlos syndrome [130] and Weill - Marchesani syndrome [131].