Sentences with phrase «gene sets involved»

Not exact matches

Cancer - focused CRISPR technology involves taking a set of molecular shears and the guiding molecule Cas9 in order to cut out unwanted genes in immune cells that may help proliferate cancers.

Because different mutations in the same gene caused the three behaviors, we concluded that per is somehow actively involved both in producing circadian rhythm in flies and in setting the rhythm's pace.

New research at the University at Buffalo reveals the first evidence that it may be possible to use a single compound to alleviate the behavioral symptoms by targeting sets of genes involved in the disease.

The new gene permanently switched on a set of genes normally affected by insulin and involved in the immune system.

When pathogens infect the cells of the body, the infection sets off a chain reaction involving the immune system that changes the activity, or expression, of hundreds of genes.

The findings highlight specific sets of genes and the brain cells they affect as being involved in regulating anxiety.

«The computational method we have proposed can be applied to other data - sets to predict new genes involved in other conditions,» says Alessandra Mezzelani, a researcher involved in the study.

He's eager to know whether this same set of genes is involved in social responsiveness of other animals.

That change, Kaufman and colleagues found, involves a set of genes that could be targeted to stop cancer from ever starting.

Eventually I went to the University of Michigan and set up a lab which was involved in trying to find genes that were the cause of various frustrating human diseases.

One person takes a drug and has a set of side effects, all of which could involve different genes.

Also, while many of the genes involved in basic cell functions are the same in this plant and animals, the set of genes for cell - to - cell communication vary dramatically between the two kingdoms.»

Dangl intends to greatly expand his efforts to understand which plant genes are involved in setting up microbe communities associated with roots.

«Yes, there is a set of diseases that occur more frequently in blacks, but they're complex diseases, involving multiple environmental factors and multiple genes too.

One gene set that stood out involved components of the spliceosome, the molecular complex that helps prepare messenger RNA (mRNA) transcripts for protein production by removing noncoding segments called introns.

Researchers observed that the set of genes involved in memory consolidation coincided with the genes regulating Crtc1, a protein which also controls genes related to the metabolism of glucose and to cancer.

They found that BET proteins regulate the growth of heart muscle cells and activate a broad set of genes involved in heart failure.

In order to address this, Greka and her colleagues began their investigation with a rare genetic type of kidney disease, and, using a rat model, set out to understand the genes, proteins, and pathways involved in the organ's deterioration.

This ancestor «started off with a whole new set of duplicate genes,» says Michael Clegg, a plant geneticist at the University California, Irvine, who was not involved with the work.

After acknowledging that there can be complicated interactions between genes, and that DNA insertion might influence regulatory networks involved in many genes, it also should be remembered that the original discovery of genes was only possible because disruption of a gene causes a limited set of changes to the organism, such as a change in eye colour.

The UK patents relate to the CRISPR - Cas9 gene editing systems involving single - guide RNA in both non-cellular and cellular settings (UK Patent No. 2518764) and chimeric CRISPR - Cas9 systems in which the Cas9 protein is modified to provide alternative DNA - modulating activities (UK Patent No. 2537000).

Genes involved in redox activity («oxidoreductase activity» GO: 0016491; P = 7.46 e − 04), those associated with responses to various stimuli, e.g., phytohormones («response to hormone» GO: 0009725; P = 2.96 e − 06), and «meristem determinacy» (GO: 0010022; P = 7.74 e − 05) were also overrepresented in the DE gene set (Table 2; Supplemental Figure 8 and Supplemental Data Set set (Table 2; Supplemental Figure 8 and Supplemental Data Set Set 5).

Using 24 factors made the process very involved, so Yamanaka set out to learn whether all of the genes were needed.

Downregulated gene sets include pathways involved in oxidative phosphorylation and amino acid, carbohydrate, and lipid metabolism; and upregulated gene sets include pathways involved in inflammation and glycan metabolism.

From these unique UM270 genes, a set of 192 CDSs was found to be involved in signaling, rhizosphere colonization and competence, highlighted as important traits to achieve an effective biocontrol and plant growth promotion.

One of the ten emerging technologies selected was the Human Cell Atlas, which aims to integrate research exploring all the «omes»: the genome (the full set of genes), the transcriptome (the RNA made from all genes), the proteome (the proteins), the metabolome (small molecules, such as sugars, fatty acids and amino acids, involved or generated by cellular processes), and the fluxome (metabolic reactions whose rates can vary under different conditions).

Shatz set out to investigate which other genes might be involved in controlling brain plasticity after birth.

Interestingly, the most commonly mutated set of genes were those involved in epigenetic modification (25 % of tumors) followed by transcriptional regulators and MAP kinase - associated genes (12 - 15 %).

The analysis of 278 transposition - induced prostate, breast and skin tumors detected tissue - specific and shared data sets of known and candidate genes involved in cancer.

Using an RNA interference screen, Swanton and his colleagues identified a set of genes involved in the regulation of mitotic arrest and in the metabolism of ceramides, lipid molecules abundant in cell membranes that influence whether tumors are sensitive to certain chemotherapy agents.

From these comparisons we should be able to identify a narrow set of genes involved in the immune system to fight plague.

More recently, it has been suggested that the contrasting attributes of gene compactness, GC content and the length of the intronic and intergenic sequences in Hkg and Tsg might be involved in chromatin mediated regulation for maintaining distinct expression patterns in the gene sets [29].

This entertaining teen comedy is set in the effervescent 1950s and involves the friendship of the introverted, clumsy Jonathan (Doug McKeon) and the nonconformist, extroverted Gene (Chris Nash).

In Activity 1, students identify the locations on chromosomes of genes involved in cancer, using a set of 139 «Cancer Gene Cards» and associated posters.

Some health problems are polygenetic (more than one set of genes involved — not a simple dominant / recessive).