Sentences with phrase «gene signature identified»

The score is based on a 12 - gene signature identified through analysis of large genomic datasets and clinical patient data.

The gene signature identified by Hancock and his colleagues relates to a special type of immune suppression called cellular reprogramming and suggests that treating inflammation in sepsis is a bad idea.

Not exact matches

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

By identifying gene expression signatures common to sight, touch and hearing, neuroscientists at the University of Geneva (UNIGE), Switzerland, discovered a sensory «lingua franca» which facilitates the brain's interpretation and integration of sensory input.

Scientists have identified unique genetic signatures strongly associated with a long and healthy life, findings that could help to further the understanding of how certain genes may offer protection from common age - related diseases like cancer, dementia and cardiovascular disease.

Anil Potti had published papers in prominent journals identifying gene signatures in tumors that could predict how a patient would respond to treatment.

Rudich says that the study enabled the researchers to identify a «signature» for each source of bacteria based on the prevalence of antibiotic resistant genes, which revealed whether the genes were local or imported from distant deserts.

Using support vector machine recursive feature elimination, the researchers identified three gene expression signatures that predicted therapy responses.

For example, the researchers were able to identify previously unknown gene expression differences between the neural stem cells that give rise to the brain's deep structures versus its neocortical surface, and to show that molecular signatures of different neural cell types arise much earlier in brain development than previously realized.

Researchers from UCL (University College London) identified an epigenetic signature in the blood of women predisposed for breast cancer owing to an inherited genetic mutation of the BRCA1 gene.

They were able to identify a «gene signature» of almost 200 genes.

The experiment's final product is equivalent to the naturally occurring genetic code of M. genitalium, with two minor exceptions: The scientists disabled the gene that gave the bug power to infect human cells, and they added a few «watermarks,» short strips of signature genetic code that identify the product as man - made.

conduct computational meta - analyses on large, aggregated cancer genome data sets to identify the long tail of infrequently mutated cancer genes, to characterise mutational signatures and to inform on the evolution of cancer cell clones.

Despite exploiting signatures displaying different statistical properties, these methods individually detected genes previously identified as undergoing selection in domesticated horses, such as KITLG (9) and melanocortin 1 receptor (MC1R)(40), providing important validation of the approach as a whole.

Coupled with a new gene - signature approach, this research project could identify compounds that will ultimately lead to the discovery of new neuropsychiatric drugs.

The team found that they could identify such signatures for half of the genes studied.

Our approach to identifying islands of divergence relies, in part, in levels of variation within populations and therefore is potentially sensitive to any process that reduces diversity within either subspecies, and thus high divergence may not be directly associated with signatures of reduced gene flow due to incompatibilities.

Recently, we have successfully applied our integrated approach to identify a 10 - gene prognostic signature for early stage lung cancer (25).

With the development of novel genomics technologies, such as Next - Generation Sequencing, numerous new mutations and gene expression signatures have been identified, allowing us to better understand the molecular heterogeneity of hematologic diseases and to better stratify and assess risk for cancer patients.

The scientists also found that these transporters have a signature sequence in their genes that makes it easy to identify them.