Sentences with phrase «gene signatures based»

Not exact matches

The researchers constructed a signature for type 2 diabetes based on 50 genes, then used publically available expression datasets to screen 3,852 compounds for drugs that potentially reverse disease.

Rudich says that the study enabled the researchers to identify a «signature» for each source of bacteria based on the prevalence of antibiotic resistant genes, which revealed whether the genes were local or imported from distant deserts.

The people with glioblastoma were divided into two groups based on the eight - gene - based risk signature, or high and low risk.

An eight - gene - based risk signature was established for risk stratification.

The NIH Common Fund's Library of Integrated Network - based Cellular Signatures (LINCS) program aims to create a network - based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents.

This clinically defined tumor type overlaps substantially but not completely with «basal - like» breast cancer, a classification based upon gene expression signature.

The score is based on a 12 - gene signature identified through analysis of large genomic datasets and clinical patient data.

Our results further show that signatures of reduced introgression are spread across the genome, suggesting that reproductive barriers in rabbits appear to have a complex genetic basis controlled by many unlinked genes.

On the basis of 326,000 polymorphisms, we found low to moderate overall levels of differentiation between subspecies, and fewer than 200 genomic regions dispersed throughout the genome showing high differentiation consistent with a signature of reduced gene flow.

Application of this strategy to the cancer predisposition gene NTHL1, which encodes a base excision repair protein, revealed a mutational footprint (signature 30) previously observed in a breast cancer cohort.