Sentences with phrase «gene signatures in»

Anil Potti had published papers in prominent journals identifying gene signatures in tumors that could predict how a patient would respond to treatment.

Not exact matches

To answer these questions, Senior lecturer Xiao - Ru Wang and colleagues examined the signature of selection among members of a large gene family, the glutathione S - transferase (GST) in pine genome.

«Cancer cells disguise themselves by switching off genes, new research reveals: A genome - wide map of the genes switched off in aggressive tumors reveals a «signature».»

In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genomIn a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genomin Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genomin different parts of the tumor, providing a «signature» of these switches throughout the genome.

These studies showing greater genetic diversity in ancient populations suggest it may not be so far - fetched to think that Siberians could have come into contact with people carrying Australasian genes, and then taken those signatures to the Americas over subsequent generations.

On its surface, the presence of Australasian genes might seem to indicate that people had sailed from that area across the Pacific Ocean to the Americas, but that genetic signature does not show up in people in the Pacific islands, which likely would have been along the route.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

The gene signature identified by Hancock and his colleagues relates to a special type of immune suppression called cellular reprogramming and suggests that treating inflammation in sepsis is a bad idea.

Today's findings augment recent research also published in Nature (Dec. 7, 2016) detailing the team's development of a «stemness biomarker» — a 17 - gene signature derived from leukemia stem cells that can predict at diagnosis which AML patients will respond to standard treatment.

Although a bad outcome was possible without the gene expression pattern, patients with the genetic signature were found to survive for less time than those who didn't have it, they wrote in the 9 December online edition of Nature Genetics.

Sure enough, salmon with a certain pattern of gene expression in their gill tissue were 13.5 times more likely to die than those that didn't carry the «you've not got long to live» signature, as co-author and University of British Columbia (U.B.C.) fish physiologist Tony Farrell puts it.

In addition to speeding up the development of brain plaques associated with Alzheimer's, a gene variant known as APOE4 also makes tau tangles — another signature of the disease — worse, researchers report online September 20 in NaturIn addition to speeding up the development of brain plaques associated with Alzheimer's, a gene variant known as APOE4 also makes tau tangles — another signature of the disease — worse, researchers report online September 20 in Naturin Nature.

«Multiple genes, capable of enhancing T - cell responses, were found in the NF - κB signature.

«We're generating so much sequence data right now, from so many species, that it's relatively straightforward to look for signatures of selection in genes and to find good candidates for adaptations,» Montooth said.

In 2006 Potti's team published several papers in high - profile journals reporting that certain gene expression signatures predicted a patient's response to chemotherapIn 2006 Potti's team published several papers in high - profile journals reporting that certain gene expression signatures predicted a patient's response to chemotherapin high - profile journals reporting that certain gene expression signatures predicted a patient's response to chemotherapy.

Their findings indicate that intuition and signatures of selection in gene sequence may not be enough for scientists to conclusively solve the puzzles of molecular evolution.

More than two decades ago, in one of the first papers using gene sequences to find signatures of natural selection, scientists hypothesized that a molecular change in an enzyme gave the Drosophila melanogaster fruit fly species its superior ability to metabolize alcohol.

His troubles also led to an Institute of Medicine report that faulted Duke's oversight and found broad problems in the cancer field with using gene signatures and other biomarkers to guide treatment.

Therefore, we sequenced the whole exomes of 98 HCCs from two hospitals in Taiwan and found that 78 % showed the distinctive mutational signature of AA exposure, accounting for most of the nonsilent mutations in known cancer driver genes.

The researchers also analyzed an independent database of 536 glioblastoma samples and found the same signature of eight genes in those cases.

In a March 2009 study published in Genes and Immunity, researchers at the National Center for Computational Toxicology compared the genetic signatures of 16 people who experienced smallpox vaccine side effects, including fever, rashes and enlarged lymph nodes, to 45 people who did noIn a March 2009 study published in Genes and Immunity, researchers at the National Center for Computational Toxicology compared the genetic signatures of 16 people who experienced smallpox vaccine side effects, including fever, rashes and enlarged lymph nodes, to 45 people who did noin Genes and Immunity, researchers at the National Center for Computational Toxicology compared the genetic signatures of 16 people who experienced smallpox vaccine side effects, including fever, rashes and enlarged lymph nodes, to 45 people who did not.

Moreover, certain signature Mimi genes, such as those that code for the production of the soccer - ball shape of its capsid (an outer protein coat common to all viruses), have been conserved in viruses that infect organisms from all three of the domains, particularly in eukaryotes.

Both approaches zeroed in on a gene that carries a signature region similar to those found in the bread - mold and fruit - fly proteins.

The Duke team has previously explored blood tests to examine a patient's RNA for gene signatures to distinguish bacterial and viral infections in the upper respiratory tract and is working with a private company to develop potential diagnostics.

Twisted signatures of GC - biased gene conversion embedded in an evolutionary stable karyotype

Epigenetic signatures in older cells — patterns of chemical marks on DNA that dictate what genes are expressed when — were reset to match younger signatures in the process.

Today, The New York Times reports that on Sunday Duke decided to halt enrollment in three clinical trials in which Potti and Duke's Joseph Nevins were using gene - expression signatures to predict a patient's response to chemotherapy.

Our next step is to start exploring our dataset in the search of such patterns of selection, for new signatures of gene flow among chimpanzee subspecies.»

But researchers are beginning to uncover a biological explanation for the problem: they have found a gene that may contribute to its development as well as a pathological signature of the disorder in the brain.

They found that 238 genes were significantly less active in the latter group — comprising a gene «signature» of metastatic myeloma.

Specifically, data from the Cancer Genome Atlas showed signatures of APOBEC3 - mediated mutations in the PIK3CA gene of about 40 percent of HPV - positive head and neck cancers, but only about 10 percent of HPV - negative head and neck cancers.

«New treatment targets cancers with particular genetic signature: Mutations in gene SETD2 make cancer cells vulnerable to drug inhibiting the protein WEE1.»

For example, the researchers were able to identify previously unknown gene expression differences between the neural stem cells that give rise to the brain's deep structures versus its neocortical surface, and to show that molecular signatures of different neural cell types arise much earlier in brain development than previously realized.

Researchers from UCL (University College London) identified an epigenetic signature in the blood of women predisposed for breast cancer owing to an inherited genetic mutation of the BRCA1 gene.

So the shark - specific signature of adaptation found in the Bag1 gene may indicate an alternative, or modified role for this important gene — one that could alter its tendency to inhibit programmed cell death in sharks.

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.

Other biomarkers and genetic signatures are being used in an effort to predict the aggressiveness of an individual patient's prostate cancer, «but the current information doesn't make it possible for their gene signature to be an actual target for precision medicine targeted therapy,» Ellis explained.

Another signature, caused by defects in repairing DNA due to mutations in the breast cancer susceptibility genes BRCA1 and 2, was found in breast, ovarian and pancreatic cancers.

Probing the mechanism of heteroresistance, Weiss and his colleagues were able to see a signature of colistin resistance, in terms of genes turned on and off.

In parthenote - derived cell lines, they found a distinctive signature: Most genes were different on the two sets of chromosomes, but genes located close to the chromosome's center were largely identical.

By manipulating the same genes, Zuo and his colleagues induced supporting cells located in the inner ear of adult mice to take on the appearance of immature hair cells and to begin producing some of the signature proteins of hair cells.

Nevertheless, variations in evolutionary signatures of selection amongst immune genes from bumblebees and honeybees may point to different pressures exerted by the distinct pathogens that threaten these bees.

Monogenic Interferon (IFN)- mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN - response - gene - signature (IRS), inflammatory organ damage and high...

About the Prosigna ® Breast Cancer Prognostic Gene Signature Assay and nCounter ® Dx Analysis System The Prosigna Assay provides a risk category and numerical score for assessment of the risk of distant recurrence of disease at 10 years in postmenopausal women with node - negative (Stage I or II) or node - positive (Stage II), hormone receptor - positive (HR +) breast cancer.

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells.

After analyzing gene expression signatures in the precursor cells, the investigators demonstrated that they could reliably predict UCP1 expression in the resulting mature cells.

In the lead profile, Jansson represented those researchers investigating such diseases by using omics technologies - uncovering the DNA sequences, expressed genes, and metabolite signatures used to reveal links to microbial functions in the guIn the lead profile, Jansson represented those researchers investigating such diseases by using omics technologies - uncovering the DNA sequences, expressed genes, and metabolite signatures used to reveal links to microbial functions in the guin the gut.

This finding is consistent with the recent discovery with several «eukaryotic» signature genes in these archaeal lineages, including genes encoding proteins such as actin, tubulin, and several proteins involved in transcription and membrane deformation.

The NIH Common Fund's Library of Integrated Network - based Cellular Signatures (LINCS) program aims to create a network - based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents.

We also have longstanding collaborations with GlaxoSmithKline to study inhibitors of the MAPK pathway in immune cells and melanoma, tumour antigens and predictive immune gene signatures.