Sentences with phrase «gene silencing by»

PRC - dependent and H3K27me3 - associated gene silencing by EBNA3A and EBNA3C has however been convincingly demonstrated at multiple gene loci (Skalska et al., 2010; Harth - Hertle et al., 2013; Kalchschmidt et al., 2016b; McClellan et al., 2012; 2013).

«The Chp1 - Tas3 core is a multifunctional platform critical for gene silencing by RITS,» appears in Nature Structural and Molecular Biology on November 13.

Since IGF2R is imprinted (i.e. one copy of the gene silenced by DNA methylation), this finding thrusted me into the rapidly growing research field of epigenetics.

Many phytochemicals can reactivate tumor suppressor genes silenced by epigenetic modifications.

Not exact matches

Now, Zhang and colleagues have discovered a new way that cells can silence some imprinted genes: by adding methyl groups to histones.

Then, researchers then sought a way to increase SMA gene product levels, the messenger RNAs (mRNAs), and thus protein levels by silencing or removing the SMN lnc - RNA.

RNA interference (RNAi) is a phylogenetically widespread gene - silencing process triggered by double - stranded RNA.

In germline cells PIWI proteins silence the RNA from jumping genes by cutting them in sequences of ~ 30 nucleotides that will become piRNAs.

He or she also has a paternal copy of the gene, but it is silenced by a long ribbon of RNA called the UBE3A anti-sense transcript.

Unlike many genetic syndromes that are caused by a mutation in a gene, people with Prader Willi often have the right gene available — it's simply that it's been silenced.

The cut DNA is then either left as - is, silencing it, or repaired by using the gene editor to slip in a new, functioning segment.

A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.

Study shows memories formed by the same gene - silencing tool used in embryonic development; a finding could set the stage for new therapies for schizophrenia

By silencing the genes that account for the three major allergy - causing proteins in peanuts, researchers at Alabama A&M University in Normal hope to grow safer peanuts.

Not only is RNAi used to regulate gene expression within an organism, it also can combat viral infection by silencing the activity of viral genes required for the pathogen's replication.

The researchers treated 63 cancer cell lines (26 breast, 14 colorectal and 23 ovarian) with low - dose 5 - azacitidine (AZA), an FDA - approved drug for myelodysplastic syndrome, that reverses epigenetic changes by stripping off the methyl group that silences the gene.

One study revealed that gene silencing triggered by mild heat stress continued in future generations of these worms, even after the initial heat stress was gone.

The copy of this gene derived from the father is normally expressed, while the copy from the mother is silenced, or «imprinted», by DNA methylation.

«Better RNA interference, inspired by nature: New nanoparticles offer best - ever gene silencing.»

Significant binding by miR -124-3p to two of the potential target genes was seen, as measured from immunoprecipitated RNA - induced silencing complexes.

By binding to DNA, H1.0 silences the expression of the genes it binds to.

The process has evolved to detect the double - stranded RNA produced by viruses, but can be repurposed to silence any gene.

This form of gene silencing is triggered by a short piece of double - stranded RNA (the chemical cousin to DNA) that matches the gene.

They managed to remove the specific enzyme for triglycerides by silencing its coding gene, but only at the heart of the reward mechanism.

In two new studies, a team of researchers led by Eva Nogales, senior faculty scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, has gained insight into the structure of PRC2 and the ways in which it is regulated to affect gene silencing.

This work is complemented by a second study that presents snapshots of PRC2 binding to the histone proteins that it modifies as a signal for gene silencing.

Some of these molecules are a complex of proteins called the Polycomb Repressive Complex 2 (PRC2) that is involved in «silencing» genes so that they are not «read» by the cellular machinery that decodes genetic information, effectively keeping the genetic information in the «off» state.

The genes in the regions of the genome that have been modified by PRC2 are switched off, or become silenced.

Structural images by a CSHL team suggest that when 3 Argonautes bind at the same time to GW182, the gene - silencing power of RNA interference (RNAi) may be enhanced.

In another paper in the same issue, a team led by molecular biologist Ronald Plasterk, now at the Hubrecht Laboratory in Utrecht, the Netherlands, reports an intriguing twist: The same genes appear to be responsible for both RNAi and another gene - silencing mechanism known as cosuppression, in which adding extra copies of a gene cause both the new and the existing copies of that gene to be shut down.

Genes that lead to the toxic effects of the huntingtin gene may be silenced by these microRNAs, in particular the miR - 10b - 5p microRNA.

By synthesizing a nanoparticle that releases its siRNA cargo only after it enters targeted cells, Dr. Tariq M. Rana and colleagues showed in mice that they could deliver drugs that silenced the genes they wanted.

To eliminate false - positive results caused by seed effects — a phenomenon by which siRNAs inadvertently silence irrelevant genes — study co-first author Aviad Tsherniak led the development of a novel computational tool dubbed DEMETER.

To show its promise, Zhang's team inserted C2c2 into E. coli bacteria, where it silenced a gene by cutting up a form of RNA that carries the gene's information to the ribosomes.

Then they generated larvae with a suppressed glycosidase activity by silencing the respective larval glycosidase gene to study the effect of lyciumoside IV ingestion on the disabled larvae.

Researchers have collected information on which genes are activated or silenced in certain diseases and by certain drugs for many years.

Drugs capable of activating silenced genes improve survival and growth outcomes in a mouse model of Prader - Willi syndrome (PWS), a rare and incurable childhood disease, according to a study funded by the National Institutes of Health (NIH).

For instance, some of these phage elements can activate or silence bacterial genes by moving into or out of the chromosome.

To determine whether the reactivation of methylation - silenced genes by EGCG is a general phenomenon that also occurs in other cell lines, we studied the effects of EGCG treatment on the methylation status and mRNA levels of p16INK4a or RARβ in three other human cancer cell lines (Fig. 3C) ⇓.

Amabile A, Migliara A, Capasso P, Biffi M, Naldini L, Lombardo A. Inheritable silencing of endogenous genes by hit - and - run targeted epigenetic editing.

By controlling the proteins that wrap the genes, scrawny can silence genes that would otherwise cause a generalized cell to differentiate into a specific type of cell, such as a skin or intestinal cell.

In these cases, it looks like the genes are being silenced at inappropriate times by epigenetic changes.

We perform the transient silencing of several genes in parallel by RNA interference in order to identify those able to modify two types of DM1 biomarkers expressed by one DM1 - hES cell line progeny: the pathological intranuclear ribonucleoaggregates called foci and the insulin receptor splicing defect.

By suppressing genes that are active in the developing embryo, silenced just before birth, and re-activated years later in many advanced cancers, the let - 7 family of «microRNAs» — tiny snippets of RNA that can put the brakes on expression of selected genes — appears to prevent human cancer cells from reasserting their prenatal capacity to divide rapidly, travel and spread.

Gene silencing is a natural adaptive defense mechanism used by plants against viruses.

By expressing foreign genes in target cell types, they hope to be able to specifically silence or activate cells of interest.

By designing the short pieces of RNA to match one particular gene, the intracellular response will specifically silence the expression of that gene.

ALS can be caused by a mutation in a protein called SOD1, and the antisense drug effectively silences the gene that codes for this mutant protein — found in the cells of patients with inherited forms of ALS.

By probing the three dimensional structure of this protein complex, called RNA - Induced Initiation of Transcriptional gene Silencing (RITS), scientists from Cold Spring Harbor Laboratory (CSHL) and their collaborators at St. Jude's Research Hospital have discovered new details of how its various parts or «domains» contribute to heterochromatin assembly and gene sSilencing (RITS), scientists from Cold Spring Harbor Laboratory (CSHL) and their collaborators at St. Jude's Research Hospital have discovered new details of how its various parts or «domains» contribute to heterochromatin assembly and gene silencingsilencing.

By the early 2000s, Joshua - Tor and colleagues including Rob Martienssen and Greg Hannon were using biochemical and structural methods to lay bare the mechanism that enabled RNAi to silence genes in a highly specific manner.