Sentences with phrase «gene silencing in»

RIPK2 gene silencing in the airways decreased allergic airway inflammation in an ovalbumin - mediated mouse model of asthma (Jun et al., 2013).

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer Genome Research, 22 (2), 246 - 258 DOI: 10.1101 / gr.125872.111

Younger ST, Corey DR. Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

It has also been suggested that methylation is not the initial event in triggering gene silencing in cancer; rather, the methylation of the promoter CpG islands is a consequence of prior gene inactivation, and it is a mechanism for locking the chromatin in a repressed state (5, 13, 37).

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo.

A major effort in the lab is to elucidate the active components of this process and to apply transcriptional gene silencing in a therapeutic setting.

«These particles, microRNA based SNAs, could also potentially be used for gene silencing in other cancers and diseases of genetic origin.»

Three techniques for identifying the collection of maternal and paternal genes silenced in offspring

Not exact matches

BOSTON, April 20 (Reuters)- Alnylam Pharmaceuticals Inc said on Friday that Dicerna Pharmaceuticals Inc will pay it $ 25 million in cash and stock to resolve a lawsuit claiming it stole trade secrets about gene - silencing technology used to develop drug treatments.

Today, there are a fair number of gene - silencing drugs in late - stage development and dozens of companies working in the space — and it feels like we could be close to a tipping point.

The gene - silencing strategy, in the form of RNA interference, has also showed promise against an uncommon neurodegenerative disease called hereditary ATTR amyloidosis, as my colleague Sy Mukherjee wrote about in Fortune's year - end Investor's Guide.

A version of this article appears in print on, on Page C3 of the New York edition with the headline: Merck Buys Maker of Gene - Silencing Drugs.

These abnormally methylated and silenced genes, says Baylin, would have blocked the increase in KRAS signaling if the genes had been properly activated under smoke - free circumstances.

Ian Baldwin of the Max Planck Institute for Chemical Ecology in Jena, Germany, and colleagues genetically modified petunia plants to silence genes responsible for producing specific scent molecules.

They also found that silencing the ADAR1 gene in the xenograft model reduced multiple myeloma regeneration.

Sutherland says the genes she studies are already silenced in healthy adult tissue, so theoretically researchers should be able to design therapies that re-silence them in cancer cells without side effects.

Our observations illustrate that an important component of genome plasticity in early development is the capacity to reverse heritable gene silencing decisions.

«SNAs are a very promising platform to silence the particular genes that drive or contribute to cancer progression in individual patients.»

«Excess folate prevents defects in DNA through methylation, a chemical process of silencing some genes but not others,» she says.

A byproduct of the discovery of RNAi was the finding that although cells in the human body only contain one strand of RNA, they do have micro-RNA — tiny sections of RNA that can act a little like double - stranded RNA and also silence the activity of certain genes.

Please recognise that the recent progress in the field of RNA - based gene silencing has involved original scientific inquiry from research groups around the world.»

Some of the genes in sperm and egg cells have chemicals called methyl molecules that attach to them, a process called methylation; these molecules can either activate or silence a gene when the sperm and egg DNA unite in an embryo.

In Martin's view, the result strongly suggested that the patients had inherited the silenced gene from one of their parents, like the case with agouti mice.

The scientists were able to see the piRNA bind to a jumping gene messenger RNA in the cell's cytoplasm and to the PIWI protein, which then cut the first section from the jumping gene mRNA to silence it.

«Our approach to gene silencing has not been demonstrated before in such a powerful way for the treatment of brain cancers,» Stegh said.

This means that once the PIWI protein from the nucleus is loaded with the new piRNAs, it's able to target the right gene in the DNA and silence it more efficiently.»

Using the new data, Laura Carrel, a geneticist at Pennsylvania State College of Medicine in Hershey, and Huntington Willard, a geneticist at Duke University in Durham, North Carolina, discovered that 15 percent of the genes on the inactivated X chromosome are actually not silenced — and most are likely to be expressed at higher levels overall in women than men.

In both groups, 30 per cent of flies died, with specific defects showing that the silenced genes controlled mainly early - stage development.

If the silencing occurred in a gene responsible for suppressing tumor formation, the result would appear the same as genetic mutations that predispose people to cancer.

«We expected simply to see the jumping gene being silenced in the cytoplasm, so were really surprised to see it get converted into new piRNAs that were specifically loaded onto the PIWI protein that silences transposons in the nucleus,» explains Ramesh Pillai, from EMBL Grenoble.

In germline cells PIWI proteins silence the RNA from jumping genes by cutting them in sequences of ~ 30 nucleotides that will become piRNAIn germline cells PIWI proteins silence the RNA from jumping genes by cutting them in sequences of ~ 30 nucleotides that will become piRNAin sequences of ~ 30 nucleotides that will become piRNAs.

Gore's team shows that the silencing of the eye genes is due to the increased activity of a specific gene involved in methylation, Futuyma points out.

They are also able to guide PIWI proteins to the jumping gene in the nucleus, which the PIWI protein silences, preventing it from creating more jumping gene RNA.

However, in a few instances, a gene is imprinted, which means that one copy is silenced.

In the Baulcombe lab, Voinnet analyzed the in vivo dynamics of gene silencing using transgenic plants, recombinant viruses, and fluorescence microscopIn the Baulcombe lab, Voinnet analyzed the in vivo dynamics of gene silencing using transgenic plants, recombinant viruses, and fluorescence microscopin vivo dynamics of gene silencing using transgenic plants, recombinant viruses, and fluorescence microscopy.

They say their study, published online in Endocrine Related Cancers, provides some surprising findings about HDAC inhibitors, which all seemingly do the same thing — remove the HDAC enzymes that wrap DNA so tightly that genes are silenced.

Determined to investigate, Voinnet specialized in plant molecular biology and, because gene silencing had also been reported in plants made resistant to viruses, plant pathology.

Angelman syndrome, which causes learning difficulties, speech problems, seizures, jerky movements and an unusually happy disposition, results when a gene inherited from the mother in a particular area of chromosome 15 is mutated and the other copy of the gene, inherited from the father, is silenced.

In cancer, these switches inappropriately activate or silence important genes, such as those that regulate cell growth and life cycle, ultimately leading to tumors.

Unlike many genetic syndromes that are caused by a mutation in a gene, people with Prader Willi often have the right gene available — it's simply that it's been silenced.

«Many of us were very surprised that the work that he did didn't earn a share of the Nobel Prize» allocated to gene - silencing discoveries in 2006, Hunt adds.

«David [Baulcombe]'s group developed a number of very interesting gene silencing systems at the time and Olivier was very good at seeing connections between these and designing elegant experiments to test them,» Hamilton, today a lecturer at the University of Glasgow in the United Kingdom, writes in an e-mail.

It silences many other genes as well, but in those cases it usually acts with another protein.

That role is especially important in a field as young as gene silencing, he says.

The cut DNA is then either left as - is, silencing it, or repaired by using the gene editor to slip in a new, functioning segment.

A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.

Study shows memories formed by the same gene - silencing tool used in embryonic development; a finding could set the stage for new therapies for schizophrenia

In a cancerous cell, the mechanisms that allow a cell to activate or silence genes are damaged.

Most research on epigenetics has focused on the way everyday experiences alter patterns of gene activity in DNA during life through a chemical process of gene tagging called methylation, which usually silences genes.