Sentences with phrase «gene silencing mechanism»

In addition, A-to-I RNA editing is involved in control of the expression and function of microRNA (miRNA), which is a small RNA essential for the RNAi mediated gene silencing mechanism.

Our and previous findings suggest that both HDACs and cytosine methylation contribute to HIV - 1 latency, in agreement with a growing body of evidence demonstrating cooperation between these two gene silencing mechanisms [55], [56].

Not exact matches

Researchers still have much to learn about the imprinting process and the genes involved, Zhang says, but the discovery of a second mechanism for silencing one copy of these genes underscores imprinting's importance.

In a cancerous cell, the mechanisms that allow a cell to activate or silence genes are damaged.

His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.

They managed to remove the specific enzyme for triglycerides by silencing its coding gene, but only at the heart of the reward mechanism.

In another paper in the same issue, a team led by molecular biologist Ronald Plasterk, now at the Hubrecht Laboratory in Utrecht, the Netherlands, reports an intriguing twist: The same genes appear to be responsible for both RNAi and another gene - silencing mechanism known as cosuppression, in which adding extra copies of a gene cause both the new and the existing copies of that gene to be shut down.

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

It has also been suggested that methylation is not the initial event in triggering gene silencing in cancer; rather, the methylation of the promoter CpG islands is a consequence of prior gene inactivation, and it is a mechanism for locking the chromatin in a repressed state (5, 13, 37).

Gene silencing is a natural adaptive defense mechanism used by plants against viruses.

In other work, the lab is exploring the mechanisms of heterochromatin formation and gene silencing through the study of a protein complex called RNA - induced initiation of transcriptional gene silencing (RITS).

Ullu was recognized for her lab's work with the protozoan parasite Trypanosoma brucei, which causes African sleeping sickness, to uncover a novel mechanism of gene silencing known as RNA interference.

By the early 2000s, Joshua - Tor and colleagues including Rob Martienssen and Greg Hannon were using biochemical and structural methods to lay bare the mechanism that enabled RNAi to silence genes in a highly specific manner.

We are interested in dissecting the mechanisms of epigenetic gene silencing and understanding the functional relevance of DNA methylation in diseases.

This result suggests that the mechanism by which IVC alters phenotype could be related to mechanisms of epigenetic gene silencing.

Silencing Viral Genes Beeologics» solution, Remebee, utilizes a mechanism called RNA interference (RNAi, also known as gene silencing) a mechanism that inhibits or hinders gene exSilencing Viral Genes Beeologics» solution, Remebee, utilizes a mechanism called RNA interference (RNAi, also known as gene silencing) a mechanism that inhibits or hinders gene exsilencing) a mechanism that inhibits or hinders gene expression.