Sentences with phrase «gene silencing research»

What's more, it can be given with a simple injection into the blood, offering great potential for research in gene silencing research and beyond.

Dr Carroll, who edited the article, has previously undertaken RNA - targeted Huntington's disease gene silencing research, and is named in an associated patent.

Not exact matches

Medical research focusing on epigenetics is currently trying to block the enzymes that regulate these changes thereby silencing cancer promoting genes.

Silencing five genes whose expression negatively correlated with caspase activity significantly increased cancer cells» sensitivity to radiation (Genome Research, DOI: 10.1101 / gr.122044.111).

Please recognise that the recent progress in the field of RNA - based gene silencing has involved original scientific inquiry from research groups around the world.»

At almost the same time, he stumbled across what would later become his research field: the first observations of gene silencing, which had started to trickle through via transgenic plant experiments.

Most research on epigenetics has focused on the way everyday experiences alter patterns of gene activity in DNA during life through a chemical process of gene tagging called methylation, which usually silences genes.

Von Roemeling and the research team then individually silenced each of the top 200 altered genes to see the effect on tumor growth.

And yet, recent research has shown that reality is much more complex: genes can be switched off, or silenced, in response to the environment or other factors, and sometimes these changes can be passed from one generation to the next.

The research team, which included scientists from Alnylam Pharmaceuticals, also found that the nanoparticles could powerfully silence genes in nonhuman primates.

Much of the previous research on epigenetics has focused on the fact that everyday experiences alter patterns of gene activity in DNA during life through a chemical process of gene tagging called methylation, which usually silences genes.

Scholar - in - Training Awards in the amount of $ 1,000 for her submitted abstract entitled, «Activator protein 2 alpha (AP2α)- targeted methylation and silencing of relevant genes in head and neck squamous cell carcinoma (HNSCC) pathogenesis» to be presented at platform session at the 100th Annual Meeting of the American Association for Cancer Research, Denver, CO..

By probing the three dimensional structure of this protein complex, called RNA - Induced Initiation of Transcriptional gene Silencing (RITS), scientists from Cold Spring Harbor Laboratory (CSHL) and their collaborators at St. Jude's Research Hospital have discovered new details of how its various parts or «domains» contribute to heterochromatin assembly and gene sSilencing (RITS), scientists from Cold Spring Harbor Laboratory (CSHL) and their collaborators at St. Jude's Research Hospital have discovered new details of how its various parts or «domains» contribute to heterochromatin assembly and gene silencingsilencing.

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer Genome Research, 22 (2), 246 - 258 DOI: 10.1101 / gr.125872.111

ONE - PARENT SAMPLE SET PARENTAL GUIDANCE RULES: Maternally methylated (red dots) and paternally methylated (blue dots) regions across the human autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expressed.

One of the most exciting avenues of HD research is huntingtin lowering (also known as gene silencing), which aims to reduce levels of the huntingtin protein in cells.

Cenix BioScience is a contract research organization focused on the discovery and pre-clinical development of novel therapeutics, specializing in advanced applications of RNA interference (RNAi) gene silencing combined with high content phenotyping in cultured cells in vitro and in animals in vivo.

In addition, the section will entertain submission of work addressing all aspects of post-transcriptional gene silencing, technologies related to microRNA analyses, as well as bioinformatics relevant to microRNA research.

The research, published in the journal Nature, described the use of RNA interference (RNAi) technology to silence genes involved in the metabolism of cholesterol read more

Since IGF2R is imprinted (i.e. one copy of the gene silenced by DNA methylation), this finding thrusted me into the rapidly growing research field of epigenetics.

Click here learn about another research project: Study Will Silence The Genes of Dogs With Degenerative Myelopathy.