Sentences with phrase «gene studies demonstrating»

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Two initial studies suggest babies with a specific version of the FADS2 gene demonstrated an IQ averaging 7 points higher if breastfed, compared with babies with a less common version of the gene who showed no improvement when breastfed.

Interestingly, this study demonstrated that Igfr2, the first imprinted gene discovered by Denise Barlow in 1991, is surrounding by a large cluster of imprinted genes that extend over 10 % of the chromosome, making it the largest co-regulated domain in the genome outside of the X chromosome.

Led by researchers at the Cincinnati Children's Hospital Medical Center Heart Institute, the study demonstrates the gene Gm7325 and its protein — which the scientists named «myomerger» — prompt muscle stem cells to fuse and develop skeletal muscles the body needs to move and survive.

After having conducted a large - scale study performed on cells from the umbilical cords of 204 newborns, the researchers from UNIGE demonstrate that DNA methylation may play both a passive and active role in gene regulation.

Further molecular biological studies by the scientists demonstrated that methylation in the non-coding region of the Igfbp2 gene contributes to less IGFBP2 synthesis.

Nevertheless,» [the] study is very important because it demonstrates for the first time that we can use gene therapy to transform cells in the brain into ones that will secrete GDNF,» says Jeffrey Kordower, a professor of neurological sciences at Rush Presbyterian Medical Center in Chicago.

A study of 1,788 adult twins is the first to demonstrate a gene by environment interaction between self - reported habitual sleep duration and depressive symptoms.

In the study, the team demonstrated that a biosynthetic gene cluster is capable of producing a whole range of substances, rather than just a single product.

In the study, researchers from Mayo Clinic in Rochester, Minn., demonstrated that reducing blood flow activated the heme oxygenase genes.

The study demonstrated that a group of trial participants with low 21 - gene recurrence score (Oncotype DX ® Recurrence Score ®) results of 10 or less who received hormonal therapy alone without chemotherapy had less than a one percent chance of distant recurrence at five years.

The study demonstrates that the evolution of resistance will likely be a severe roadblock for existing CRISPR gene drive approaches, which must be addressed before scientists could successfully employ them in the wild.

«The vectors developed and characterized in this study demonstrate unique and potent biology that justify their consideration for gene therapy applications,» Vandenberghe says.

Constellation of factors Twin studies have shown that identical twins (who share the same genes) are more likely to both suffer from the disorder than fraternal twins, which has demonstrated that «there's a large genetic component to the disorder,» Cantor says.

One study even identified two genes in which particular variants can slow the onset of AIDS, demonstrating the potential of this approach for understanding why people vary in their susceptibility to infectious diseases.

A study published January 4th in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with diabetes.

The proof - of - concept study, published online today in the journal Nature, demonstrates that a gene called PGC1 alpha provides kidneys with protection by working through nicotinamide adenine dinucleotide (NAD), a molecule involved in metabolism thought to be key to the aging process.

In a new study published in the journal Scientific Reports, UFZ researchers have been able to demonstrate that these so - called fungal hyphae also form a hot spot for gene transfer between bacteria.

A 2008 study at Sweden's Lund University demonstrated that drinking coffee lowers the risk of breast cancer, at least for women who have a relatively common variant of the gene CYP1A2, which helps to metabolize both estrogen and coffee.

The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases.

«Synthetic biology is a new area that's really exciting to young scientists — to have things begin to work in this way is a sort of validation of the field,» says Pamela Silver, a professor of systems biology at Harvard University Medical School and co-author of a study demonstrating one of the first synthetic restructurings of a eukaryotic cell that is described in the journal Genes & Development.

According to Saura, «this study opens up new perspectives on therapeutic prevention and treatment of Alzheimer's disease, given that we have demonstrated that a gene therapy which activates the Crtc1 protein is effective in preventing the loss of memory in lab mice».

In the present study, the scientists demonstrated that the drug BI-97D6 increased cancer cell death caused by mda - 7 / IL - 24, and it also helped defend against resistance to the viral gene therapy.

In a study led by Michigan State University, scientists have shown that gene editing using CRISPR / Cas9 technology can be quite effective in rhesus monkey embryos ¬ - the first time this has been demonstrated in the U.S.

And in a follow - up study presented at the American Chemical Society meeting in San Diego, California, this month, Al - Abed and colleagues demonstrated that mice lacking the MIF gene remained healthy after being injected with streptozotocin.

The newly published PLOS ONE study assessed the long - term efficacy of the therapy and demonstrated that a single gene therapy treatment led to prolonged production of VNA in blood and protected the mice from subsequent exposures to C. botulinum toxin for up to several months.

M.D. Waterfield and colleagues demonstrate that the sis oncogene of simian sarcoma virus encodes platelet - derived growth factor, the first study to find the function of a cancer causing gene.

The study demonstrates that variations in the PDE4D gene are significantly associated with ischemic stroke.

In a previous study, Shaw, an associate professor in Salk's Molecular and Cell Biology Laboratory and researcher in the Institute's new Helmsley Center for Genomic Medicine, demonstrated that cells lacking a normal copy of the LKB1 gene fail to activate AMPK in response to low energy levels.

The study also demonstrates an association between NCAN variations with volumes of certain brain regions in young adults and infants, suggesting that the gene is able to affect brain structure and function.

His group also studies two genes implicated in familial breast cancer, BRCA1 and BRCA2, and recently demonstrated that their action is linked to the cell's division cycle, and that BRCA1 regulates gene activity.

The study zeros in on the genes that may lead to the marked extroverted behavior seen in children with Williams syndrome, demonstrating that «hyper - sociability» — especially the drive to greet and interact with strangers — follows a unique developmental path.

Dr. Verma's group is also studying two genes implicated in familial breast cancer, BRCA1 and BRCA2, and recently demonstrated that their action is linked to the cell's division cycle and that BRCA1 regulates gene activity.

The current study demonstrates that the Tbx4 gene, normally active in the leg, can convert tissue from the wing area into a complete and normal leg.»

The results of the study show that hereditary factors play a significant role for more than 75 per cent of the proteins, and a detailed genetic analysis demonstrates 16 genes with a strong effect on protein levels.

Previous studies have linked gene expression profiles in bCSCs with a clinical outcome [1, 2], and in this study the authors have extended this out to demonstrate that a DNA methylation profile may promote these changes, and furthermore, that this profile can be effectively used to predict prognosis, and potentially aid the therapeutic decision making.

Using mutated versions of the lamin A gene as an example to demonstrate the versatility of their virus - based approach, researchers at the Salk Institute for Biological Studies successfully edited a diseased gene in patient - specific induced pluripotent stem cells as well as adult stem cells.

The studies demonstrate that the daily pattern of gene activity is not lost with age but is rather reprogrammed for new functions and that a low calorie diet delays alterations in the rhythm of stem cells.

The study demonstrated the advantages of having an integrated approach to gene prediction and developed a computational framework for combining multiple genome annotations.

2/13/2007 Study Shows Liver an Excellent Target For Cancer Gene Therapy Using Viral Vectors A featured paper in the February issue of the research journal Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differen... MorGene Therapy Using Viral Vectors A featured paper in the February issue of the research journal Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differen... MorGene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differen... Morgene therapy using adenoviral vectors, based upon a fundamental new understanding of the differen... More...

We have pioneered studies demonstrating that low - yielding wild and exotic Oryza species harbor genes and quantitative trait loci (QTL) that can be used to enhance the performance of modern, high - yielding rice cultivars.

Cas9 / gRNA - mediated gene targeting demonstrated in this study can be used for other livestock species, which will contribute to advancing transgenic applications of large animal in biomedical and agricultural sciences.

The present study and others have demonstrated that the miR - 181a target genes, Smad1, Smad5 and Zeb2 are important regulators of BMP / GDF - induced mDA neuronal growth [37,41].

«Our study demonstrates that even well - studied bacteria — the ones that we know cause disease or their close relatives — have many genes associated with antibiotic resistance that have not been characterized before,» said senior author Gautam Dantas, PhD, associate professor of pathology and immunology.

Importantly, these studies to elucidate gene contacts in the 3D nuclei of live cells have demonstrated that condensin - mediated contacts between centromeres and the genomic loci carrying Pol III - transcribed genes or retrotransposons are highly dynamic.

This study additionally demonstrates that the systematic examination of panels of biological candidate genes in large, well - characterised populations can be an effective complement to positional cloning approaches.

Two independent teams — one led by David Page at MIT, the other by Henrik Kaessmann and Diego Cortez at the University of Lausanne in Switzerland — studied a wide variety of animals to demonstrate that the Y chromosome eventually developed a stable set of genes.

These studies demonstrate that the two important protein complexes, condensin and cohesin, are both essential for the assembly of the functional genome architecture, but their roles in the 3D genome organization (gene contacts and topological domain organization) are significantly different.

Interaction with ERAP genes was determined in patients positive for HLA - C * 04:01 In silico docking studies were also performed for HLA - C * 04:01 RESULTS: Fifteen SNPs demonstrated nominal significance (P < 1 × 10 -LRB--5)-RRB- with one or more of the hypersensitivity phenotypes.

This is the first study demonstrating smoking - induced expression changes for this particular set of genes and importantly, it is the first time partial reversibility (MUC5AC) and irreversibility (GSK3B) and has been demonstrated using two different cohorts of samples with two independent assays for expression quantification.

This led him to undertake a series of studies beginning in 1977 that demonstrated gene targeting in animal cells and culminated in the construction of one of the first knockout mice in 1989.