Sentences with phrase «gene targeting in»

This led him to undertake a series of studies beginning in 1977 that demonstrated gene targeting in animal cells and culminated in the construction of one of the first knockout mice in 1989.

Site - directed mutagenesis by gene targeting in mouse embryo - derived stem cells.

Asuri, Prashanth, et al. «Directed evolution of adeno - associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells.»

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

We study microRNA function by profiling these regulators and their gene targets in the single cells where the interactions between them occur.

Analysis of FOXP2 gene targets in human neural tissues reveal that a subset of these play roles in activity - based sculpting of neural connections, including during learning [48], [49].

Among the other 42 gene targets tested, representing genes located within the chromosome, linear plasmids and circular plasmids, gene transcription was detected in both duplicate samples of 22 gene targets in saline - treated mice, particularly in heart base samples.

Not exact matches

The technology's possibilities are staggering — in theory, allowing medical scientists to do everything from cure genetic disorders like sickle cell disease to identify gene targets for combating HIV.

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

Luxturna is the first of a crop of treatments that target diseases caused by mutations in specific genes, and thus is referred to by many as the first gene therapy in the U.S.

In our tests, the Gene Knockout Kit gave us greater than 80 percent knock - out rates for seven targets,» shares Shondra Miller, Ph.D., Director, Center for Advanced Genome Engineering at St. Jude Children's Research Hospital, on Synthego's web site.

Alnylam has been developing drugs that target gene expression in order to prevent to production of certain biological material which can cause devastating diseases.

Well, one startup is seeking to take a very different approach: Exonics Therapeutics, which has secured $ 5 million in seed funding from CureDuchenne Ventures to see if the revolutionary new CRISPR - Cas - 9 gene - editing technology can be used to target the root genetic deficiency at the heart of the disease.

The Kamens claim the main thing that distinguishes their foundation from other brain tumor foundations is their focus on pediatric brain cancer specifically, as well as their close ties with pharmaceutical and biotech companies working in the fields of immunotherapy and target gene therapy.

'' «At PMV Pharmaceuticals, we are targeting the most frequently mutated gene in human cancer (p53) to make an unprecedented impact on cancer patients» lives.

Tech analyst Gene Munster is predicting that Amazon will buy Target in 2018.

«Mar - 18 is the third out of three quarters that they have failed to meet this important target,» Loup Ventures managing partner Gene Munster said in a note.

«It's definitely something that we are thinking about,» said Gene Han, a vice president who heads Target's innovation center in San Francisco, where the startup pitch meeting was held.

In the study, whole - exome sequencing and a targeted analysis of 90 genes implicated in heart disease were applied to 419 unrelated SIDS caseIn the study, whole - exome sequencing and a targeted analysis of 90 genes implicated in heart disease were applied to 419 unrelated SIDS casein heart disease were applied to 419 unrelated SIDS cases.

Using a gene - sequencing technique known as whole - exome sequencing that targets only the DNA that encodes proteins, the researchers cataloged virtually every significant DNA variant in three families in which the condition is common.

In addition, they also used exome sequencing and RNAseq — sequencing directly targeted to the SHIP1 gene — to examine the structure of the SHIP1 gene at both the DNA and the RNA level.

To generate a rich source of potential vaccine and drug target candidates, the team identified a set of genes that are more active in certain stages of the parasite life cycle and within the parasite's gut.

To discover these targets, the team determined when and where each gene is turned on or off in the cells and tissues of H. contortus to reveal new insights into the worm's lifecycle.

Because the genes that are massively amplified in the neochromosomes are essential for the cell's survival, drugs that turn those off are an obvious target for research.

«The extensive overlap in risk genes for autism and cancer, many of which are chromatin remodeling factors, supports the idea of repurposing epigenetic drugs used in cancer treatment as targeted treatments for autism,» said Yan.

These experiments revealed that the CLOCK protein targets the per gene in mice and both the per and tim genes in flies.

Some morphogenic gradients apparently yield but a single effect: If the concentration of a morphogen in a particular place is above a critical threshold, a target gene is activated; otherwise, it is not.

In SIF - seq, hundreds or thousands of DNA fragments to be tested for enhancer activity are coupled to a reporter gene and targeted into a single, reproducible site in embryonic cell genomeIn SIF - seq, hundreds or thousands of DNA fragments to be tested for enhancer activity are coupled to a reporter gene and targeted into a single, reproducible site in embryonic cell genomein embryonic cell genomes.

Researchers don't think there's a single pathway or gene in a prey bacterium that the predator targets.

The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.

New research at the University at Buffalo reveals the first evidence that it may be possible to use a single compound to alleviate the behavioral symptoms by targeting sets of genes involved in the disease.

In particular, he has focused on targeting the gene coding for flagellin protein b, or flaB, which has proved to be quite distinct from one genospecies to the next.

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manneIn all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent mannein a concentration - dependent manner.

Women with precancer or cancer were most likely to have particular versions of the viral gene E7, which researchers are now interested in targeting.

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient's response to therapy.

Ko is working to adapt a procedure used so far in pigs, cows and other animals to target genes in cloned dogs.

The Bill and Melinda Gates Foundation sees so much promise in gene drive technology that it plans to double spending on its Target Malaria initiative, which aims to create systems for driving genes in two species of malaria mosquitoes, to $ 70 million.

«Many diseases, especially complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.

«Blocking a gene reduces fat: Major clinical study targeting illnesses linked to excessive fat in blood.»

Using this process, scientists can make targeted mutations in the genomes of living animals, either deleting genes or inserting new ones.

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

If drugs could target the corresponding gene in people, it might allow dieters to keep burning calories at the same rate they do when eating normally.

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

This study took a different approach — targeting a drug to a protein that controls how genes are turned on and off, early in the viral replication process.

Homozygous mutant mice in which the Jak3 gene had been disrupted were generated by gene targeting.

After moving to Berkeley, he arrived at a career crossroads in 1994, when Spyros Artavanis - Tsakonas, then at Yale, discovered and subsequently patented the human relative of the fruit fly gene notch, which plays a role in cell - to - cell interactions and could be an anti-cancer target.

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

«The next step is to identify antibodies and small - molecule drugs that can successfully target Helios or genes in the Helios pathway,» says the study's lead author, Hye - Jung Kim, PhD, of Dana - Farber.

Dr. Satish Rattan, Professor in the Department of Medicine, Division of Gastroenterology and Hepatology at Jefferson's Sidney Kimmel Medical College, together with Drs. Jagmohan Singh and Ipsita Mohanty, used altered copies of the body's own genetic make - up — small RNA fragments (microRNAs) that regulate the target gene RhoA / ROCK — in order to strengthen or weaken the muscle tone of the sphincter.

«If these genes would have a role [in humans], it would be very exciting to try to [make] medicines that target some of these genes,» Moreno says.