Sentences with phrase «gene therapy methods»

Lentiviral - based gene therapy methods to modify human CD34 + hematopoietic stem cells have been investigated as a way of treating various hematological disorders including X-linked chronic granulomatous disease (X-CGD).

Skeletal muscle is one of the largest tissues in the human body and current gene therapy methods are only able to affect a portion of the muscle.

We want to use gene therapy methods to protect people against HIV.

The permanent gene therapy method could be a nonsurgical contraceptive approach for pets or stray animals.

Not exact matches

In a Policy Forum in the new issue of Science, Theodore Friedmann, M.D., from the University of California in San Diego and colleagues from Montreal and Washington, D.C., highlight how gene therapy and other methods of genetic modification are poised to complicate international sports competitions like the Olympics, and indeed already have.

Anderson and others are already exploring new gene - delivery methods, including nanoparticles, to better deliver gene - editing therapies to target tissues.

But as new methods of genetic modification emerge, both the scientific and the sports communities are becoming increasingly aware that gene therapy — the insertion of genes into an individual's cells and tissues — will make its way onto the playing field.

The new method may make some types of gene therapy easier and could be a boon for researchers hoping to control gene activity in animals, scientists say.

This approach may make gene therapy a viable method for delivery of polypeptides that require rapid and regulated delivery.

Antisense therapy is not strictly a form of gene therapy, but is a genetically - mediated therapy and is often considered together with other methods.

The new method may make some types of gene therapy easier...

«It's a method that is much more feasible and safer for patients than traditional gene therapy, which uses modified viruses to carry out the treatment.»

The benefit of this approach over other gene therapy techniques is that the new method can permanently correct the «defect» in a gene rather than just transiently adding a «functional» one, said Dr. Eric Olson, Director of the Hamon Center for Regenerative Science and Medicine at UT Southwestern and Chairman of Molecular Biology.

Other experts say the method could help induce the immune system to tolerate other gene therapy agents beside adenovirus.

The method, reported in the November issue of Nature Biotechnology, could lead to safe and effective human gene therapies for cystic fibrosis, hemophilia, and a variety of other diseases.

To prevent this decline in Area X, White's research team used methods similar to human gene therapy to insert a version of FoxP2 in male zebra finches.

The roadmap outlines future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, the coordination of regenerative and ablative technologies, and methods of slowing metabolic activity while preserving cognitive function.

Reference materials are critical to properly evaluate the next - generation of gene sequencing and genetic testing methods that will increase the reliability and effectiveness of precision medicine (also known as «personalized medicine»), in which a person's genetic profile is used to create treatments and therapies unique to that individual.

«Engineering novel methods of delivering monoclonal antibodies could be an important approach in the fight against infection and in unique treatment situations,» said senior author David B. Weiner, PhD, a professor of Pathology and Laboratory Medicine and chair of the Gene Therapy and Vaccine Program.

Robert Beall becomes CEO of the CFF and, grasping the limitations of gene therapy, invests $ 3.2 million in Aurora Biosciences Corp., where cell physiologist Paul Negulescu begins to look for a chemical cure using high - throughput methods to test large numbers of potential drugs.

In particular, the advanced drug delivery systems he has developed provide new methods for nanoparticulate drug delivery, non-viral gene therapy, siRNA delivery, and vaccines.

Gene therapy and suicide gene therapy have been pursued in lung cancer, each method has its advantages and disadvantages.11 - 13 Gene therapy needs vehicles for the transfection of the genetic material mainly the viral and non-viGene therapy and suicide gene therapy have been pursued in lung cancer, each method has its advantages and disadvantages.11 - 13 Gene therapy needs vehicles for the transfection of the genetic material mainly the viral and non-vigene therapy have been pursued in lung cancer, each method has its advantages and disadvantages.11 - 13 Gene therapy needs vehicles for the transfection of the genetic material mainly the viral and non-viGene therapy needs vehicles for the transfection of the genetic material mainly the viral and non-viral.

The latest developments in CAR - T translation and manufacturing including alternate gene transfer methods to deliver CARs; novel gene editing approaches, advances in CAR design to improve safety and efficacy, and progress in creating an «off - the - shelf» allogeneic CAR - T therapy.

The only plausible methods of repairing stochastic nuclear DNA damage look to be the aforementioned advanced molecular nanotechnology, something that lies some decades in the future, or major advances in gene therapy, to the point at which it could be cost - effective and safe to scan and conditionally alter the majority of genes in the majority of cells all at once.

«With our enhanced method of direct cardiac reprogramming, we hope to combine gene therapy with drugs to create better treatments for patients suffering from this devastating disease.»

Summary: University of Chicago researchers have developed the first practical method to limit activity of therapeutic genes to a specific cell type (smooth muscle cells), clearing a major safety hurdle facing gene therapy.

September 1, 1997 Targeting gene therapy to specific cells Researchers at the University of Chicago Medical Center have developed the first practical method to restrict the activity of genes used for gene therapy to a specific cell type.

One method that could soon be used to change human genetics is called germline gene therapy.

Figure 5: An overview of gene therapy vectors (adapted from An Introduction to Transfection Methods.

The scientists say their method, which repairs the beta - globin gene (HBB), avoids gene therapy techniques that can introduce potentially harmful genes into cells.

And because each cell has its own unique set of mutations, we can not solve them with the methods of gene therapy in the adult organism either today or tomorrow.

Bethesda, Md., Wed., Oct. 26, 2016 - For the first time, National Institutes of Health (NIH) researchers have demonstrated in mice that gene therapy may be the best method for correcting the single faulty gene that causes Niemann - Pick disease, type C1 (NPC1).

For the first time, National Institutes of Health (NIH) researchers have demonstrated in mice that gene therapy may be the best method for correcting the single faulty gene that causes Niemann - Pick disease, type C1 (NPC1).

4) Gene therapy is a set of methods that uses genes to treat or prevent disease by inserting genes into a patient's cells.

Preparation and global prosecution of patent applications directed to diagnostic and therapeutic products including antibodies, gene therapies, vaccines, stem cells, pharmaceutical formulations, nanotechnology, nucleic acid molecules, biologics, medical devices, mouse platforms for antibody development, and methods of treating diseases.