Sentences with phrase «gene therapy vectors»

Although gene therapy vectors delivered to brain were used for this research, Davidson envisions developing a small molecule that can appropriately modulate this pathway.

Now the Boston Children's research team reports restoring a much higher level of hearing — down to 25 decibels, the equivalent of a whisper — using an improved gene therapy vector developed at Massachusetts Eye and Ear.

The results drew attention in part because they come from the lab of James Wilson at the University of Pennsylvania, who led a 1999 trial in which a teenager died from an immune reaction to a different gene therapy vector.

However, low gene therapy vector transduction efficiencies still represent a major hurdle.

Segura, M.M., Kamen, A., Garnier, A. «Downstream processing of oncoretroviral and lentiviral gene therapy vectors.»

AAV gene therapy vectors are emerging as the gene transfer vehicle with high potential for use in the CNS as they transduce post mitotic cells that mediate the sustained, long term gene expression required in chronic progressive diseases.

Despite the marginal improvements in survival of patients suffering from malignant glioma treated with gene therapy vectors, the clinical trials conducted so far using viral vectors, in particular adenoviral vectors, have proven that the use of adenoviral vectors is a safe therapeutic approach, even in large, multicenter, phase 3 clinical trials.

Research done by the Universitat Autònoma de Barcelona introduced gene therapy vectors through a minimally - invasive procedure (various injections through the canine's rear legs) to cure type 1 diabetes.

Now Sands's group and collaborators have evidence suggesting that the gene therapy vector did, in fact, trigger the cancers.

One subject self - infused two days after receiving the gene therapy vector.

Many life - saving products, such as recombinant therapeutic proteins, vaccines, and gene therapy vectors, are produced from large - scale cell culture systems.

In the health care industry, many life - saving products, such as recombinant therapeutic proteins, vaccines, and gene therapy vectors, are produced from large - scale cell culture systems.

The technology also improves cell culture systems used to produce therapeutic proteins, vaccines, and gene therapy vectors.

None of the offspring tested positive for the presence of the normal KL2 gene carried by the gene therapy vector.

In the second half of the study, we will test whether our gene therapy vector is effective at halting the progression of an optic neuropathy in rodents.

He is one of the world's leading authorities in gene therapy, having developed a gene therapy vector, based on a stripped - down version of HIV, that successfully delivers genes for therapeutic purposes.

The gene therapy vector was developed at St. Jude.

Dr. Verma and colleagues developed a gene therapy vector, based on a stripped - down version of HIV, that can deliver genes to non-dividing cells.

A robot like this could potentially be used to infuse drugs at targeted points in the brain, or to deliver gene therapy vectors.