Sentences with phrase «gene transcription»

The epigenetic information ensures the spatial and timely organization of gene transcription that determines cell identity.

She has worked on signaling and gene transcription for many years, is a member of numerous advisory panels, and has received several major awards.

The first way our genes get the big red or green light is through gene transcription.

Developed primary culture models of activity - dependent gene transcription and of HD.

With single - cell RNA sequencing, much more gene transcription was detected than before.

This project takes the next step, shifting the focus to the regulatory elements that control gene transcription.

This permits the production of massive amounts of protein during developmental periods so brief, gene transcription alone is not enough.

The Morris lab has since determined the mechanistic underpinnings of non-coding RNA mediated regulation of gene transcription in human cells, with evidence suggesting a role for longer forms of non-coding RNAs as endogenous effectors involved in epigenetically remodelling target loci in human cells.

The approach was also used to regulate gene transcription at endogenous genomic sites when combined with CRISPR / Cas9 technology.

«This study, for the first time, identifies a novel role of a histone variant protein in regulating gene transcription aside from its established roles,» said senior author Xiaobing Shi, Ph.D., assistant professor of Biochemistry and Molecular Biology at The University of Texas MD Anderson Cancer Center.

Using an innovative crystallization technique for studying three - dimensional structures of gene transcription machinery, an international team of researchers, led by scientists at Penn State, has revealed new insights into the long debated action of the «magic spot» — a molecule that controls gene expression in Eschericahia coli and many other bacteria when the bacteria are stressed.

We can compare the diverse tasks performed by a colony to the many proteins generated by gene transcription, to various cell types of a developing embryo, or to the firing patterns of neurons in the brain.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

His present research focuses on gene transcription and gene therapy for AIDS and cancer.

In the absence of Wnt signaling, we found that Tcf factors associate with proteins of the Groucho family of transcriptional repressors to repress target gene transcription.

10/10/2007 Researchers Reveal Repressor Protein Blocks Neural Stem Cell Development A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... More...

The epigenetic impairments reflect changes that increase accessibility of chromatin, a process that enhances gene transcription, suggesting the impairments play an important role in addiction behavior.

This type of histone methylation enables the function of these regions as enhancer sequences, i.e. as marks that can be identified by specific proteins which boost gene transcription.

«Ebright and colleagues present a crystal structure that captures a network of interactions between an activator protein bound to DNA and RNA polymerase (the primary enzyme of gene expression) as it is poised to begin gene transcription.

However, the researchers found that a variation of ECR47 associated with ADHD disrupted ECR47's ability to bind an important neurodevelopmental transcription factor, YY1 — an indication that the risk variant interferes with gene transcription.

Melanocytes respond by altering gene transcription, and these changes in gene expression profiles result in easily quantifiable phenotypes such as modified pigment production (a hallmark of melanocyte differentiation state) and changes in morphological cell properties.

Defense: «Effects of canopy cover and pH on polyketide synthase gene transcription in Cladonie stygia and the polyketides produced in natural conditions.»

Once inside the cell, it can interfere with bacterial cell signal transduction and gene transcription processes.

[9] This is achieved through gene transcription which is followed by the processes of translation and assembly of proteins into the contractile architecture.

On the other hand, as a dimer, it directly binds to response elements in the DNA (GC - response elements), thus inducing gene transcription (transactivation).

Novel Isoforms of Heat Shock Transcription Factor 1, HSF1?a and HSF1?ß, Regulate Chaperone Protein Gene Transcription.

In Study 2, rats fed fermentable RS had increased cecal weights and plasma PYY and GLP - 1, and increased gene transcription of PYY and proglucagon.

PRMT1 is involved in a number of genetic processes including gene transcription, DNA repair and signaling.

Other therapies might slow gene transcription so cells make less ApoE protein to begin with.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

«One of these effectors mimics the host transcription factors, directly targeting and activating the host gene transcription of a plant sugar transporter.

Intriguingly, the team discovered that the very first «letter» (base) of the RNA message is very important for efficient gene transcription.

This image depicts an oncogenic lncRNA FAL1 (the dragon) dysregulating gene transcription and promoting tumorigenesis.

Millar's group showed that decreased proliferation and Keratin 9 expression in the absence of WNT10A resulted from failure of signaling through a well - characterized pathway that stabilizes a protein called beta - catenin, allowing it to enter the cell nucleus and activate gene transcription.

She and her team developed the method Break - seq to test their hypothesis that chromosome fragile sites result from collisions between drug - induced unstable DNA replication and untimely gene transcription.

Using bioinformatics tools to identify and map out specific components and regulatory interconnections, the study team found highly dynamic activities during CD8 + T cell responses: a distinct repertoire of super enhancers — groups of enhancers that interact with promoters to drive gene transcription, new groups of enhancers that jump into activity only in the memory cell stage, and extensive re-wiring of regulatory circuits from one cell stage to another.

In the Nature papers, the researchers compared gene transcription, chromatin modification and other processes that control gene activity in a wide range of mouse and human tissues and cell types.

Finally, for a fifth project, NCI wants to use so - called synthetic lethal screens, which use tools such as siRNA (molecules that block gene transcription) to discover combinations of proteins that cancer cells with mutated RAS need to survive.

How cells ensure appropriate access to «promoter» DNA, the regions where gene transcription begins, is still poorly understood.

Found that proteins bound to the cytoplasmic portion of one subtype of glutamate receptor, the N - methyl - D - aspartate receptor, play a critical role coupling local calcium influx through the channel to elicit adaptive gene transcription in neurons.

They found that TDRD3 forms a complex with a protein called topoisomerase 3B (TOP3B), an enzyme that unwinds DNA and, in so doing, prevents DNA structures from forming that impede gene transcription.

Importantly, for the maintenance of healthy plaque pH, gene transcription activity of known and previously unrecognized pH - neutralizing pathways was associated with the genera Lactobacillus, Veillonella and Streptococcus during the pH recovery phase.

We hypothesize that loss of MLL3 / KMT2C function leads to a shift in the enhancer landscape, altering the sites available for estrogen receptor binding and thus changing gene transcription in breast cancer.