Sentences with phrase «gene transcription activity»

Importantly, for the maintenance of healthy plaque pH, gene transcription activity of known and previously unrecognized pH - neutralizing pathways was associated with the genera Lactobacillus, Veillonella and Streptococcus during the pH recovery phase.

Not exact matches

These included sites involved in regulating gene activity during brain development and initiating the transcription of genes.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

In Class I engagement, Sox9 binds to the genome indirectly via the basal transcriptional complex, regulating transcription of genes for basal cell activities.

In Class I engagement, Sox9 binds indirectly to the DNA and regulates the transcription of genes involved in basal cell activities.

Transcription - factor genes code for proteins that regulate the activity of other genes and so affect an animal's ability to respond to its environment.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

The oxidation status of STAT3, in turn, determined how efficiently the transcription factor regulates gene activity.

We know that Hox genes encode transcription factors that control the activity of other genes, but we found that digit - innervating motor neurons also express other genes, such as FIGN and CNEP4], and we still don't know the function of any of these other genes.

This reflects the normal daily variations of transcription activity in these genes.

By impairing or enhancing transcription, these modifications are able to influence gene activity.

Blau's group found that the daily changes in Rho1 activity are controlled by rhythms in transcription of a gene very similar to human Puratrophin - 1.

Transcription factors are proteins that help control gene activity, usually turning it up a notch or two.

Using bioinformatics tools to identify and map out specific components and regulatory interconnections, the study team found highly dynamic activities during CD8 + T cell responses: a distinct repertoire of super enhancers — groups of enhancers that interact with promoters to drive gene transcription, new groups of enhancers that jump into activity only in the memory cell stage, and extensive re-wiring of regulatory circuits from one cell stage to another.

To start, the scientists examined previous experiments and identified several transcription factors — managerial proteins that switch on the activity of large sets of genes — that seemed crucial to the ability of immature neurons to develop into adult sensory neurons.

In the Nature papers, the researchers compared gene transcription, chromatin modification and other processes that control gene activity in a wide range of mouse and human tissues and cell types.

The second gene would then manufacture its corresponding transcription factor, which was designed to bind to and ratchet up the activity of the same gene that created it.

MYCN and its kin are «transcription factors,» proteins that bind to DNA and influence the rate at which genetic information is used by the cell — essentially serving as brightener / dimmer switches for gene activity.

«These findings directly contradict the traditional view that the Y is largely heterochromatic with a paucity of genes and transcription activity,» said the researchers, who released their findings in the current online issue of Proceedings of the National Academy of Sciences.

The activity of each gene then was analyzed in an attempt to find the specific transcription factor responsible for regulating the conversion of sugar to starch in the above - ground portions of the plant, primarily the grains.

Whereas liver and blood gene activity patterns showed the expected differences among the three groupswith human transcription looking similar to that of the chimp, and different from that of the more evolutionarily distant macaquegene activity in the brain revealed stark differences between humans and chimps.

Pbo's group thus turned their attention to levels of gene activity, or transcription.

«I think this is going to be a fairly complex thing to work out,» Reeves says, adding that Ets2 encodes a transcription factor that influences the activity of at least 200 other genes.

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.

In research published this week in the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the development of one type of retinal neuron, the horizontal cells.

Plakophilin - 3 Catenin Associates with the ETV1 / ER81 Transcription Factor to Positively Modulate Gene Activity.

The mechanism by which MNLPs modify gene activity is not yet known; a leading hypothesis is that the short sequences change a promoter's ability to bind proteins that regulate transcription.

Using chromatin accessibility and gene expression measurements, we present clear evidence that lineage specific enhancer dynamics in hematopoiesis is the result of lineage specific transcription factor activity.

The histone proteins are decorated with different marks, which can affect the various activities of the modified DNA such as transcription, gene silencing, imprinting and replication.

Previous studies have implicated FOXM1, which encodes a transcription factor protein capable of regulating the activity of many other genes, in many other human cancers, including liver, breast, lung, prostate, colon, and pancreatic cancers.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

Both encode transcription factors that help regulate the activity of other genes.

The transcription factors usually function as homodimers or heterodimers to regulate the gene expression in eukaryotic cells and their activities are dependent on distinct protein - protein interaction.

The regulatory system of these cells consists basically of proteins called transcription factors that control the activity of many genes — which in turn comprise the molecular machinery that instructs cells to develop into their mature, functioning state.

UT MD Anderson Scientists Discover Secret Life of Chromatin (08/30/2011) A team of researchers directed by Dr. Sharon Dent, director of the Department of Epigenetics and Molecular Carcinogenesis and Center for Cancer Epigenetics, investigate a signaling activity of chromatin that is independent of its central role in gene transcription.

For example, our studies identified transcription factors, RNA binding proteins, and signaling genes as critical miRNA targets during contexts such as development of peripheral sensory organs, wing, eye, and CNS, or during behavioral contexts such as egg - laying, rhythmic behavior, and locomotor activity (Figure 2).

The 1500 transcription factors (TFs) within the human genome perform a key role in determining the set of active genes within a specific cell, as well as the magnitude of activity.

To gain insight into how mammalian gene expression is controlled by rapidly evolving regulatory elements, we jointly analysed promoter and enhancer activity with downstream transcription levels in liver samples from 15 species.

Gene ontology (GO) analysis of genes within 250 kb of a PORE sequence revealed enrichment in processes such as transcription regulator activity (p < 0.001), sex determination (p < 0.005), insulin receptor signaling (p < 0.001), development (p < 0.0005), and protein phosphorylation (p < 0.005).

Selection for expression of the gene requires transcription from a cellular promoter, and consequently a mutation in a cellular gene, and the activity of the tagged gene can be followed by staining for beta galactosidase activity.

The resource provides services including: processing of the samples (cells or tissues) to make high quality chromatin for ChIP, ChIP with a set of validated antibodies for histone marks (Promoter marks: H3K4me3 and H3K27me3, Enhancer marks: H3K4me1 and H3K27ac, Gene body marks for transcription activity: H3K36me3 and H3K79me2, and Heterochromatin mark: H3K9me3), ChIP with investigator preferred custom antibodies, and library preparation from ChIP DNA and multi-plexing for high - throughput DNA sequencing.

Through this mechanism, it would be possible for a cell to couple extracellular cues to maintenance of pluripotency through direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment dictates.

BGEM contains images for more than 400 genes with DNA binding and / or transcription factor activity, and more than 300 genes with protein translation and protein transport activity.

More recently, a common variable number tandem repeat (VNTR) polymorphism lying 1.2 kb upstream of the transcription initiation site of MAOA has been shown to affect transcriptional activity of the gene in transfected cells.