Sentences with phrase «gene transcription in»

Gene transcription in sea otters (Enhydra lutris); development of a diagnostic tool for sea otter and ecosystem health.

It may be possible to accurately modify gene transcription in vivo using CRISPR without cleaving DNA, according to recent research

Defense: «Effects of canopy cover and pH on polyketide synthase gene transcription in Cladonie stygia and the polyketides produced in natural conditions.»

We hypothesize that loss of MLL3 / KMT2C function leads to a shift in the enhancer landscape, altering the sites available for estrogen receptor binding and thus changing gene transcription in breast cancer.

Chisholm, D, Devitt, N, Ngam P, Lindquist, I, Schilkey F, Linder, C. Lost in Transcription Using Transcriptomics to Identify Differential Gene Transcription in the Testis of Infertile Golga3repro27 Mice..

Found that proteins bound to the cytoplasmic portion of one subtype of glutamate receptor, the N - methyl - D - aspartate receptor, play a critical role coupling local calcium influx through the channel to elicit adaptive gene transcription in neurons.

An analysis of all gene transcription in the cultured cell lines turned up a large gene complex in which gene expression differed conspicuously in cells from patients compared to controls.

Not exact matches

We can compare the diverse tasks performed by a colony to the many proteins generated by gene transcription, to various cell types of a developing embryo, or to the firing patterns of neurons in the brain.

The epigenetic impairments reflect changes that increase accessibility of chromatin, a process that enhances gene transcription, suggesting the impairments play an important role in addiction behavior.

These included sites involved in regulating gene activity during brain development and initiating the transcription of genes.

PRMT1 is involved in a number of genetic processes including gene transcription, DNA repair and signaling.

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manneIn all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent mannein a concentration - dependent manner.

The gene encodes a transcription factor, a protein that in this case binds to DNA and allows it to be read out as messenger RNA.

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

«Our lab took part in analysing the group of RNA or transcriptome, that results from transcription, the process by which the instructions in the genes are read.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

Based on the transcript sequences, the researchers identified 1,437 new promoters — short DNA sequences where transcription begins — in or between genes, on top of the 1,730 promoters they knew of.

Project members also catalogued sequences that mark areas where DNA unwinds from the round histone proteins that maintain the shape of chromosomes, allowing the cell's transcription machinery to activate genes in those areas.

In this way the binding of the DNA to the corresponding nucleosome is changed so that the DNA for example becomes accessible for transcription enzymes and activates a particular gene.

Transcription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kiTranscription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors on steroids: their actions regulate thousands of genes in different kinds of cells.

As in any good marriage, moreover, the attachment of the methyl groups significantly altered the behavior of whichever gene they wed, inhibiting its transcription, much like a jealous spouse.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

In Class I engagement, Sox9 binds to the genome indirectly via the basal transcriptional complex, regulating transcription of genes for basal cell activities.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that affects expression of the telomerase gene, or a change in the expression of a transcription factor or other regulatory proteins that binds to the promoter upstream of the telomerase gene.

In Class I engagement, Sox9 binds indirectly to the DNA and regulates the transcription of genes involved in basal cell activitieIn Class I engagement, Sox9 binds indirectly to the DNA and regulates the transcription of genes involved in basal cell activitiein basal cell activities.

In Class II engagement, Sox9 binds to multiple active enhancer elements through sub-optimal, low - affinity Sox dimeric motifs (DNA sequences), resulting in a high level of transcription of cartilage - related geneIn Class II engagement, Sox9 binds to multiple active enhancer elements through sub-optimal, low - affinity Sox dimeric motifs (DNA sequences), resulting in a high level of transcription of cartilage - related genein a high level of transcription of cartilage - related genes.

In the paper, the researchers illustrate how it could influence proteins that activate the transcription factors that transcribe major bone - related genes to drive bone formation — showing a link between metabolite usage and activation of transcription factors.

In addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growtIn addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growtin the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growth.

In Class II engagement, it binds directly to the DNA in multiple locations and activates transcription of cartilage - related geneIn Class II engagement, it binds directly to the DNA in multiple locations and activates transcription of cartilage - related genein multiple locations and activates transcription of cartilage - related genes.

Spalax naturally have a variant in the p53 gene (a transcription factor and known tumor suppressor), which is identical to a cancer - related mutation in humans, Band said.

Alternative splicing was long considered a rare hiccup during transcription, but researchers have concluded that it may occur in half — some say close to all — of our genes.

The oxidation status of STAT3, in turn, determined how efficiently the transcription factor regulates gene activity.

Using an innovative crystallization technique for studying three - dimensional structures of gene transcription machinery, an international team of researchers, led by scientists at Penn State, has revealed new insights into the long debated action of the «magic spot» — a molecule that controls gene expression in Eschericahia coli and many other bacteria when the bacteria are stressed.

Disease processes often begin with mutations in the transcription factor, or in the DNA they bind to inside the nucleus of cells to regulate the complex interplay of genes needed for a healthy functioning body.

In most cases, the genes responsible for these processes are known as «transcription factors» — meaning that they are responsible for turning other genes on and off.

During this time, transcription — the conversion of gene «recipes» encoded in DNA to mRNA, the messenger that carries the recipe to the cell's protein - making machinery — is completely shut off.

By studying Arabidopsis plants for which the genes for these transcription factors had been selectively knocked out, the group identified a single transcription factor that when inactive resulted in longer roots.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

He will promote high - throughput technologies in areas that are «poised for this kind of approach,» such as gene transcription and autism studies.

Thus, the late phase of LTP in the CA1 region requires transcription during a critical period, perhaps because cAMP - inducible genes must be expressed during this period.

They tested their system on a pair of yeast transcription factors and used the data to predict which yeast genes the proteins would target, they report in this week's Science.

The researchers also showed that histone propionylation can drive transcription in the test tube (in vitro) suggesting it is a stimulatory mark capable of causing genes to be expressed when it is present.

The genes — Oct 3/4, Sox2, c - Myc and Klf4 — are molecular switches called transcription factors, which activate other genes in series like a power strip.

This work, published in the journal Molecular Cell, reveals a new role for each nucleus» several hundred pores, which constitute as many microscopic factories of gene transcription.

This reflects the normal daily variations of transcription activity in these genes.

Glk1 is a transcription factor, meaning it binds to specific regions of DNA and activates genes involved in cell death and other plant immune responses.

«Calcium signaling regulates many important cellular functions, like muscle contraction, neural communication, gene transcription and tissue growth,» said Fenfang Li, a postdoctoral research fellow in Zhong's laboratory and lead author of the study.

In their research, Pugh and Venters set out to identify the precise location of the beginnings of transcription — the first step in the expression of genes into proteinIn their research, Pugh and Venters set out to identify the precise location of the beginnings of transcription — the first step in the expression of genes into proteinin the expression of genes into proteins.