Sentences with phrase «gene transcription which»

[9] This is achieved through gene transcription which is followed by the processes of translation and assembly of proteins into the contractile architecture.

Not exact matches

«Our lab took part in analysing the group of RNA or transcriptome, that results from transcription, the process by which the instructions in the genes are read.

The guilty protein is beta - catenin, a transcription factor which activates other genes.

Aiolos is a member of a class of proteins called transcription factors — proteins that control which genes are turned on or off by binding to DNA and other proteins.

«Perhaps the methylation of the gene can be compared with a dimming switch, which regulates the transcription of the gene and thus the amount of the enzyme formed.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

«By analysing the first nucleotides we are able to identify which sequence of gene starts the transcription.

Spalax naturally have a variant in the p53 gene (a transcription factor and known tumor suppressor), which is identical to a cancer - related mutation in humans, Band said.

Wyrick and his colleagues also saw less damage around transcription factors, proteins that bind to specific, short stretches of DNA and regulate gene expression by controlling which genes are turned on and off.

By studying Arabidopsis plants for which the genes for these transcription factors had been selectively knocked out, the group identified a single transcription factor that when inactive resulted in longer roots.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

They tested their system on a pair of yeast transcription factors and used the data to predict which yeast genes the proteins would target, they report in this week's Science.

The genes — Oct 3/4, Sox2, c - Myc and Klf4 — are molecular switches called transcription factors, which activate other genes in series like a power strip.

This work, published in the journal Molecular Cell, reveals a new role for each nucleus» several hundred pores, which constitute as many microscopic factories of gene transcription.

Genes become more or less active at the touch of proteins called transcription factors, each of which can influence hundreds or thousands of other gGenes become more or less active at the touch of proteins called transcription factors, each of which can influence hundreds or thousands of other genesgenes.

All of these genes code for transcription factors, which are proteins that control the expression of other genes.

Using the recently completed tomato genome sequence they then identified the gene as SlGLK2 — a so - called transcription factor, which controls when and where other genes are switched on or off.

We had started working on this more than a year ago, when we tried inserting four transcription factors, which regulate genes, into the skin cells.

These include proteins which control important processes in the cells, for example the transcription factors which activate genes for the production of new proteins.

FosB is a transcription factor in the brain which, together with other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines whether certain genes are activated or not.

The researchers also investigated the impact of aneuploidy on other biological pathways, such as transcription, the first stage of gene expression in which a segment of DNA is copied into RNA.

At that point, a particular type of protein called a transcription activator can kick - start the molecular process by which a gene gets turned on.

Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway.

The switch, in turn, is flicked on by proteins called transcription factors, which activate certain genes in response to certain stimuli.

«We concluded that RAC1 regulates lung branching morphogenesis, in part through the so - called canonical Wnt signaling pathway, which leads to the regulation of the transcription of many genes,» said principal investigator Denise Al Alam, PhD, of the Department of Surgery and the Developmental Biology and Regenerative Medicine Program at The Saban Research Institute.

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA.

This type of histone methylation enables the function of these regions as enhancer sequences, i.e. as marks that can be identified by specific proteins which boost gene transcription.

It does so by activating the transcription factor STAT3, which in turn inhibits expression of the miR - 34a gene by directly binding to it.»

The second gene would then manufacture its corresponding transcription factor, which was designed to bind to and ratchet up the activity of the same gene that created it.

The therapy consists in injecting into the hippocampus - a region of the brain essential to memory processing - a gene which causes the production of a protein blocked in patients with Alzheimer's, the «Crtc1» (CREB regulated transcription coactivator - 1).

MYCN and its kin are «transcription factors,» proteins that bind to DNA and influence the rate at which genetic information is used by the cell — essentially serving as brightener / dimmer switches for gene activity.

A major process of gene expression is transcription, by which RNA is synthesized according to a DNA template.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

In 2003, Sun and colleagues had discovered a so - called transcription factor, which turns on genes involved in making starch.

In early work in Sweden, Jansson and his team investigated how distribution of sugars in plants could be controlled by a special protein called a transcription factor, which binds to certain genes and turns them on or off.

An analysis of all gene transcription in the cultured cell lines turned up a large gene complex in which gene expression differed conspicuously in cells from patients compared to controls.

This strict selectiveness of sensory neurons is in part due to enhancers (DNA sequences that enhance transcription of a gene when bound by specific protein), which remain poorly understood.

To find that gene, developmental biologist Deepak Srivastava of the University of Texas Southwestern Medical Center at Dallas and colleagues studied development of the mouse heart, in which a transcription factor called dHAND was known to turn on an array of crucial genes.

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.

Mal - gluc modulates histone acetylation of the Rac1 gene and allows transcription activators to access the DNA for increased transcription in the brain, which influences the expression of genes responsible for synaptic plasticity.

Transcription factors determine which genes are active at what time and in which conditions and consequently have a critical role in organisms.

Transcription factors — both natural and artificial — determine which genes are translated into proteins inside cells.

Furthermore, GNC and GNL act, at the gene expression level, in an additive manner with the GOLDEN2 - LIKE1 (GLK1) and GLK2 transcription factor genes, which are also important for proper chlorophyll accumulation.

«The replication and transcription machineries are therefore active simultaneously on genes carrying a replication origin, which causes conflicts.

The researchers classified pri - miRNAs into three broad categories based on gene structure: Class I, which are transcribed independently of other genes and likely represent independent transcription units, Class II, which are transcribed as an extension of a protein - coding gene, and Class III, which are transcribed as an extension of a noncoding RNA.

When mapped to the genome, they tell us not only about the level of expression for various genes, but also which transcription start sites were used.

In particular, we examined the reprogramming capacity of the proneural genes neurogenin - 2, Ascl1 and the homeobox transcription factor Dlx2, for reasons which become clear in the following.

This, in turn, because the scientists did not know which DNA sequences are functional, and bind to the specific proteins called transcription factors that regulate gene expression.

Apart from involvement in DNA repair, TRF2, has been reported to interact with β - catenin which is a transcription factor and also a developmental gene [12].

In fact, they found that TGF - β halts both the transcription of the p53 gene - the process by which cellular machinery reads the DNA code for a gene - and the subsequent process by which the corresponding p53 protein is produced, known as translation.