Sentences with phrase «gene transduction»
Gene transduction refers to the process of transferring genetic material into a cell, usually through a virus or another vector. This allows the targeted cell to acquire and express the transferred genes, which can be used for various purposes such as treating diseases or modifying traits. Full definition
The use of viral vectors in research is beneficial for a number of reasons, including but not limited to: helping to get difficult - to - deliver DNA into mammalian cells, increasing the efficiency of gene transduction, allowing for control over which cells are infected through viral pseudotyping, and ease of vector cloning and modification.
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However, their initial finding demonstrated that progenitor derived from iPSCs generated using lentiviral gene transduction led to the high incidence of highly aggressive tumors in immunodeficient mice after transplantation under the kidney capsule.
Creation and validation of a ligation - independent cloning (LIC) retroviral vector for stable gene transduction in mammalian cells.
However, it is practically difficult to perform the rescue experiments in the organoid culture system because the lentivirus transfection is required for the gene transduction into the primary stem / progenitor cells and the APC gene (> 8.5 k base pairs) is too large to be cloned into the lentivirus.