Sentences with phrase «gene transfer»

Finding similar sequences is not a full proof that they are the result of horizontal gene transfer, but in the case of sweet potato there are strong indications that this has happened.

Even unrelated species become more important as techniques of gene transfer improve.

They would be created through the process of lateral gene transfer, in which microbes incorporate loose bits of genetic material from other microbes into their own.

In addition, branch members are developing gene transfer therapy.

What's more, some of the ways that natural gene transfers occur are being exploited by genetic engineers.

An additional research focus includes synthetic modifications, such as applying click chemistry to DNA, building brighter probes for diagnostics and optimizing gene transfer.

But evidence is piling up that wholesale exchanges of genetic material — called lateral gene transfers — can quickly create entirely new species.

This information may help to predict which other bacterial species might participate in this form of gene transfer, and to identify just how widespread the phenomenon is.

Conjugation is the main route for horizontal gene transfer in bacteria and is responsible for the spread of antibiotic resistance.

The Amborella Genome Project (p. 10.1126 / science.1241089) was able to infer that a whole - genome duplication event preceded the evolution of this ancestral angiosperm, and Rice et al. (p. 1468) found that numerous genes in the mitochondrion were acquired by horizontal gene transfer from other plants, including almost four entire mitochondrial genomes from mosses and algae.

High level erythroid lineage - directed gene expression using globin gene regulatory elements following lentiviral vector mediated gene transfer into primitive human and murine hematopoietic cells.

In a new study published in the journal Scientific Reports, UFZ researchers have been able to demonstrate that these so - called fungal hyphae also form a hot spot for gene transfer between bacteria.

Defects in T - cell - mediated immunity to influenza virus in murine Wiskott - Aldrich syndrome are corrected by oncoretroviral vector - mediated gene transfer into repopulating hematopoietic cells.

In the 1980s, Dr. Kaufman's experience with gene transfer and engineering led him to become a founding scientist at Genetics Institute Inc., where he engineered mammalian cells for high - level expression of therapeutic proteins, such as clotting factors that are now used to treat individuals with hemophilia.

Studies are also underway evaluating therapeutic gene transfer approaches to treat cardiac and skeletal muscle dysfunction in X-linked muscular dystrophy golden retriever dogs.

Beyond the medical risks to the potential child, a number of long - standing ethical concerns exist regarding the possible practice of germline gene transfer in both human and nonhuman cases.

The mission of the Institute is to perform innovative research on gene transfer and cell transplantation, and to translate its results into successful clinical application for genetic diseases.

My laboratory has already developed molecules and gene transfer vectors that can target either the MAC, through the delivery of a protein called CD59, or the anaphylatoxins by delivery of proteases, or both by a protein called PRELP.

Welch et al. «Expression of Ribozymes in Gene Transfer Systems to Modulate Target RNA Levels», Current Opinion in Biotechnology, 9: 486 - 496, 1998.

Treatment of malignant glioma using gene transfer modalities typically consists of surgical debulking of the tumor mass followed by the administration of the viral vectors into the brain tissue surrounding the tumor cavity.

The team also confirmed differences in mating strategies, notably that the pathogenic fungus can mate with itself, which influences gene transfer between generations and genome repair mechanisms, whereas the Quorn ™ fungus would need to find a mate.

He was a Helen Hay Whitney fellow with Nobel Laureate Dr. Phillip Sharp at the Center for Cancer Research at the Massachusetts Institute of Technology (M.I.T.), where he developed gene transfer technologies based on gene amplification and expression in mammalian cells.

During that time, he took a six - month sabbatical at the Center for Molecular Orthopaedics, Harvard Medical School / Brigham and Women's Hospital, in Boston to learn viral gene transfer techniques.

Such gene transfer «would be sufficient to increase genetic variation and promote evolution», says Yoshida.

Evaluation of resistance gene transfer from heat - treated Escherichia coli — Laëtitia Le Devendec — International Journal of Food Microbiology

Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus - based lentiviral vector system.

In another experiment, the researchers used viral gene transfer and increased RbAp48expression inthe DG of aged mice.

But it stopped short of recommending a protocol - by - protocol approval process, something that the Recombinant DNA Advisory Committee implements for human gene transfer research.

The study, titled «Restoration of spermatogenesis by lentiviral gene transfer: Offspring from infertile mice,» was funded by the National Institutes of Health, the March of Dimes Birth Defects Foundation, the Wayne and Gladys Valley Foundation, and the H. N. and Frances C. Berger Foundation.

The latest developments in CAR - T translation and manufacturing including alternate gene transfer methods to deliver CARs; novel gene editing approaches, advances in CAR design to improve safety and efficacy, and progress in creating an «off - the - shelf» allogeneic CAR - T therapy.

«Once we had discovered 120 new variants, we started testing them and, lo and behold, some were significantly better in terms of gene transfer efficiency to specific tissues and organs,» Wilson says.

The controversy centers on possible cases of horizontal gene transfer across phylogenetic branches that were ignored by these authors and on an insufficient correction for multiple substitutions.

Since then, he has performed evolutionary analyses on a bacterial gene transfer system evolved from domesticated bacteriophages, and on the architecture of bacterial chromosomes.

Having been excited by the potential of retroviral gene transfer as a therapeutic, it has been a fascinating opportunity to get to grips with the various processes in the lab; particularly more recently when I have spent time working independently to optimise the process in various cell subsets.

Go Deeper Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways Cre - dependent Selection Yields AAV Variants for Widespread Gene Transfer to the Adult Brain

Her research initially focused on the identification and characterization of juvenile dilated cardiomyopathy in Portuguese water dogs and has led to several ongoing studies, including most recently the evaluation of various candidate genes for use in a therapeutic gene transfer approach to improve cardiac function in failing hearts.

We examine systems related to horizontal gene transfer which involve the DNA translocation across the cell membranes.

Studies can also include gene transfer systems such as transformation, conjugation and transduction.

With respect to antibiotic resistance, this novelty can be induced and we can trace the novelty to particular mutations arising absent gene transfer; i.e. the genes which give rise the resistance were not present prior to the mutation, they are new sequences and not simply the activation of dormant genes.

They note that targeting inflammation to treat infections offers an advantage over antibiotic therapy, as the former hinders gene transfer and the evolution of pathogens, while the latter promotes bacterial evolution and, ultimately, antibiotic resistance.

Viral - mediated gene transfer now enables investigators to overexpress or knock out a gene of interest within highly localized regions of brain.

«This regenerative technology, termed AAV gene transfer, provided long - lasting benefit to the entire musculature of affected dogs that would have otherwise perished, extending a healthy lifespan for more than 4 years,» said Dr. Martin Childers, senior author of the Muscle & Nerve study and a UW Medicine researcher in Seattle.

Over many years, the NTNU University Museum has been studying what such an extreme gene transfer system means for the global propagation of these plants.

The study clearly shows the utility of the adeno - associated virus in long - lasting gene transfer, says molecular geneticist Rudolph Leibel, an obesity researcher at Columbia University in New York City.

Horizontal gene transfer allows prokaryotes to acquire «preexisting adaptations from other microbes,» says Treangen, which enables them to rapidly establish themselves in new environments.