Sentences with phrase «gene transfer approaches»

Studies are also underway evaluating therapeutic gene transfer approaches to treat cardiac and skeletal muscle dysfunction in X-linked muscular dystrophy golden retriever dogs.

This study will combine direct tumor cell killing (TK) and immune - mediated stimulatory (Flt3L) gene transfer approaches delivered by first generation adenoviral vectors.

However, like most gene transfer approaches a major concern with ZFN technology is the potential for oncogenesis due to off - target effects.

«One way of treating patients with limb - girdle muscular dystrophy might be to use a gene transfer approach to treat the muscular dystrophy, and a pharmacological approach to treat the smooth muscle dysfunction,» he said.

Her research initially focused on the identification and characterization of juvenile dilated cardiomyopathy in Portuguese water dogs and has led to several ongoing studies, including most recently the evaluation of various candidate genes for use in a therapeutic gene transfer approach to improve cardiac function in failing hearts.

Not exact matches

This approach entails transferring a healthy (non-mutant) copy of the defective gene to restore the expression of the missing protein.

In one such approach, researchers surgically remove brain cells, use viruses to transfer genes to the cells, and then graft them back into the animal's brain tissue.

His team's approach is based on gene therapy, where a «tame» virus is harnessed to transfer a gene into target cells in the recipient.

Dr. Stoddart's main research focus is using autologous stem cells and gene transfer to repair musculoskeletal tissues using a cell therapy approach.

«Gene therapy approaches fall into two main categories: (1) the transfer of a gene that stimulates the immune system and (2) the insertion of genes within the tumor that sensitizes the tumor to a relatively nontoxic «prodrug.&raGene therapy approaches fall into two main categories: (1) the transfer of a gene that stimulates the immune system and (2) the insertion of genes within the tumor that sensitizes the tumor to a relatively nontoxic «prodrug.&ragene that stimulates the immune system and (2) the insertion of genes within the tumor that sensitizes the tumor to a relatively nontoxic «prodrug.»

The latest developments in CAR - T translation and manufacturing including alternate gene transfer methods to deliver CARs; novel gene editing approaches, advances in CAR design to improve safety and efficacy, and progress in creating an «off - the - shelf» allogeneic CAR - T therapy.

«The data from this study show the promise of vector - mediated gene transfer as an approach for immunization,» says Pat Fast, chief medical officer at the International AIDS Vaccine Initiative.

Ultimately the goal is to translate this work to gene transfer treatment approaches for canine idiopathic dilated cardiomyopathy and human heart failure.