The latest developments in CAR - T translation and manufacturing including alternate
gene transfer methods to deliver CARs; novel gene editing approaches, advances in CAR design to improve safety and efficacy, and progress in creating an «off - the - shelf» allogeneic CAR - T therapy.
Not exact matches
These include
genes from plants and organisms unrelated to rice that could not be
transferred using other breeding
methods.
Once specific
genes associated with beneficial traits are identified, they can be more efficiently
transferred into new rice varieties using other breeding
methods.
But this
method of gaining new DNA, termed horizontal
gene transfer, was thought to be relatively rare and to occur only under strong pressures in the environment, such as exposure to powerful antibiotics.
Research areas include species for comparative research; phenotypic characterization; fitness, genome stability and lateral
gene transfer; control of organismal traits; monitoring and surveillance; modeling and standardization of
methods and data.
Two key events enabled organelles to develop: The precursor bacteria
transferred many of their
genes to the host's genome, and they developed a
method of transporting the proteins produced by these and other
genes back inside their own membranes.
The new
method circumvents the problem of not being able to culture many of these bacteria in the lab by
transferring genes from these bacteria into another bacterial species that is easier to work with.
The panel, chaired by Bettie Sue Masters of the University of Texas Health Science Center in San Antonio, distinguished between crops that are genetically engineered (GE)-- having a
gene deleted or
transferred between species — and those that are genetically modified by other
methods.
It focused on flagging sources of uncertainty and evaluating
methods of testing fitness, genetic stability and lateral
gene transfer.
«Now that we have the
gene, we can actually use that
gene sequence to temporarily silence the
gene and make rye and other chromosomes pair with wheat and
transfer genes by a natural
method into wheat without calling it GMO,» Gill said.
Physical
Methods for
Gene Transfer: Improving the Kinetics of
Gene Delivery into Cells.