Using a novel
technique to genetically modify T cells for adoptive
transfer, Carl June, Michael Kalos, David Porter, Bruce Levine, and colleagues at the University of Pennsylvania School of Medicine achieve clinical responses in patients with chronic lymphocytic leukemia, including two complete, durable (one year) clinical responses, accompanied by in vivo expansion and long - term functional persistence of
gene - modified cells.
Spectroscopy & Application of Lasers, Zare / Moerner / +, 6 - 1 Nuclear Hormone Signaling, Chambon / Evans / Jensen, 6 - 1 Bioinorganic Chemistry, Gray / Lippard / Holm / — , 8 - 1 The Field (everything not listed), 10 - 1
Techniques in DNA Synthesis, Caruthers / Hood / +, 10 - 1 Electrochemistry / Electron
Transfer, Bard / Hush / Gray / — , 19 - 1 Instrumentation /
Techniques in Genomics, Venter / +, 19 - 1 Biological Membrane Vesicles, Rothman / Schekman / +, 19 - 1 Molecular Studies of
Gene Recognition, Ptashne, 19 - 1 Organic Electronics, Tang / +, 39 - 1 Polymer Science, Matyjaszewski / Langer / + / — 69 - 1 Solar Cells, Grätzel / +, 74 - 1 Mechanistic Enzymology, Walsh / Stubbe / Koshland / + / — , 74 - 1 Combinatorial Chemistry / DOS, Schreiber / +, 99 - 1 Pigments of Life, Battersby / +, 99 - 1 Development of the Birth Control Pill, Djerassi, 99 - 1 Molecular Modeling and Assorted Applications, Karplus / Houk / Schleyer / Miller / + / — , 99 - 1 Applications of NMR Spectroscopy, Pines / Roberts / McConnell / + / — , 99 - 1 Development of Chemical Biology, Schultz / Schreiber / +, 99 - 1 Self - Assembly, Whitesides / Nuzzo / Stang / — , 149 - 1 Small Regulatory RNA, Ambros / Baulcombe / Ruvkun, 149 - 1 Nanotechnology, Lieber / Whitesides / Alivisatos / Mirkin / Seeman / + / — , 149 - 1 Eukaryotic RNA Polymerases, Roeder, 149 - 1 Contributions to Theoretical Physical Chemistry, Rice / +, 149 - 1 Mechanical Bonds and Applications, Sauvage / Stoddart / +, 149 - 1 Bio - & Organo - catalysis, List / Lerner / Barbas / + / — , 149 - 1 Organic Synthesis, Evans / Danishefsky / Nicolaou / Ley / Trost / Stork / Wender / Kishi / + / — , 199 - 1 Leptin, Coleman / Friedman / Leong, 199 - 1 Fluorocarbons, DuPont / Curran / — , 199 - 1 Understanding of Organic Stereochemistry, Mislow, 199 - 1 Tissue Engineering, Langer / +, 199 - 1 Contributions to Bioorganic Chemistry, Breslow / Eschenmoser / +, 199 - 1 Dendrimers, Frechet / Tomalia / +, 399 - 1 Zeolites, Flanigan, 399 - 1 Molecular Recognition, Dervan / +, 399 - 1 Molecular Machines, Stoddart / Tour / + / — , 399 - 1 Astrochemistry, Oka, 999 - 1