Sentences with phrase «gene variant increases»

Having this gene variant increases the odds of having blood pressure that is sensitive to salt, the researchers determined previously.

A special gene variant increases the risk of heavy smoking.

Not exact matches

These SCARB1 gene variant studies aren't the only ones to challenge the long - held belief that increasing HDL was the key to reducing heart disease risk.

A large - scale genetic study published in The Lancet in 2012 found no relationship between gene variants that increased HDL and the likelihood of heart attack (though this research did not evaluate the SCARB1 variants).

The archaic - like variants are associated with an increase in the activity of the TLR genes and with greater reactivity to pathogens.

Among the DNA variants known to cause Alzheimer's or increase risk of the disease, none are found in the tau gene.

We used the LD signal strength as a guide to find our way to the true risk gene — the particular variant that actually caused the increased risk for lupus.»

Dr Antonio Pardiñas, first author of the study, said: «We show for the first time that genetic variants that do not severely impact gene function, but presumably have a more subtle impact on these critical genes, increase risk for developing schizophrenia.»

The celiac - associated variant of lnc13 binds poorly to these proteins, leading to increased expression of inflammatory genes.

The team also examined data from a prior genetic study of children with asthma and found that a variant of the dectin - 1 gene — which reduces production of the receptor — is strongly linked to increased asthma risk.

Certain gene variants are associated with an increased risk of disease, but MS is rarely directly inherited.

Genetic factors can contribute to the degree of longevity in at least two important ways: An individual may inherit certain genetic variations that predispose him or her to disease that decreases longevity; other gene variants may confer disease resistance, thereby increasing it.

Large - scale genomic studies will probably uncover more gene variants associated with increased risk of developing PTSD, says de Quervain, and may provide a better understanding of the molecular mechanisms involved.

Having just one copy of a particular variant of a gene called CREBRF is associated with a 1.5 increase in BMI.

The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.

Scientists also know dozens of gene variants that increase people's risk of lupus.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

Among the gene variants modern humans inherited from Neandertals are ones associated with higher cholesterol, increased belly fat, rheumatoid arthritis and schizophrenia, researchers learned from analysis of the new Neandertal DNA.

«A new blue gene: NKPD1 variant increases depression risk.»

Carrying a particular version of the gene for apolipoprotein E (APOE) is the major known genetic risk factor for the sporadic, late - onset form of Alzheimer's disease, but exactly how that variant confers increased risk has been controversial among researchers.

In the work presented here, we were able to show that stress — represented by financial hardship — led to an increase in migraine in those who have a particular gene variant.

This year, however, researchers linked variants of more than 50 genes to increased risk for a dozen diseases.

For example, some people have a particular variant of the ADH1B gene that causes an amino acid change in this enzyme, which leads to faster enzyme activity so individuals with this variant metabolize alcohol more rapidly which means that acetaldehyde levels are temporarily increased.

That group also concluded that the increased risk of sepsis caused the defective variant to replace the original gene.

Then the researchers found that those participants in the epidemiologic study with a genetic variant in the ALDH gene were at increased risk of Parkinson's when exposed to these pesticides.

But what about people who have inherited gene variants known to increase risk?

A rare gene variant discovered by UCL (University College London) scientists is associated with an increased risk of developing schizophrenia, bipolar disorder and alcoholism, confirms new research.

The FRO2 gene is common to all plants, so boosting its expression in food crops or finding variants that thrive in poor soils could be important for increasing crop yields in the face of population growth and global warming's threats to arable land.

It found that people with the variant of the GRM3 gene, thought to be important in brain signalling, were at increased risk of developing bipolar disorder, schizophrenia and alcohol dependence.

Seven of these gene variants, as expected, appeared to increase risk for both diseases.

The variant uncovered in the study increases the degree to which p53 activates its target gene to stimulate cell production.

These scientists studied whether a gene variant in the FTO gene, which regulates the appetite and thereby increases the individual's BMI, is also linked to a series of cardiovascular diseases and metabolism.

The Neurogenomiks research group, linked to the Achucarro Basque Centre for Neuroscience (EHUgroup) and the University of the Basque Country (UPV / EHU), has just had a research article published in the scientific publication Journal of Immunology; it details how they have managed to show that the gene known as ANKRD55 produces 3 different transcripts of the messenger RNA, and that the genetic variant associated with MS greatly increases the production of these transcripts.

In this study we found that individuals with gene variants that lead to increased body - mass index (BMI) also had an increased risk of heart failure and diabetes.

A study led by Leif Groop of Lund University in Sweden, using data from two long - term health studies, confirmed that result and also found that people carrying the high - blood - sugar gene variant have an increased risk of developing type 2 diabetes.

One possible hypothesis: coffee hounds have gene variants that increase their metabolism of caffeine, «so to maintain levels that give them [the same] fix, they require more» coffee, Cornelis says.

They then compared genetic variants that lead to thin corneas in mice, to genes that increase a person's risk of a common type of glaucoma, called primary open angle glaucoma.

A variant of the gene, called ApoE4, dramatically increases the risk of developing late - onset Alzheimer's disease.

In a study, published in Science, they investigated a gene region that contains a particular single nucleotide variant associated with increased risk for developing colorectal and prostate cancers — and found that removing this region caused dramatic resistance to tumor formation.

A genetic variant in the region of the GLUL gene was identified that is associated with an increased risk of CHD in type 2 diabetics.

For example, a particular gene variant in the promoter region of the IL10 gene is associated with a 40 to 60 % increased risk of developing active tuberculosis among Europeans and Americans [75].

While those studies identified several gene variants that appeared to increase the risk of each disorder, none of the associations were strong enough to meet the strict standards of genome - wide significance.

According to Andreassen, the study's senior author, some think of schizophrenia as a «side effect» arising from advantageous variants in genes that are related to the development of human traits, such as cognitive and language skills, that may have increased risks for developing psychoses.

«The finding that certain variants of the PKP - 2 gene may increase the risk of developing the disease opens new possibilities in understanding the disease mechanism leading to atopic dermatitis,» continues Katarina Tengvall.

Perhaps the most striking result is that carrying the variant increases the already high risk of breast cancer in women who also carry the Icelandic founder risk mutation in the BRCA2 gene.

The researchers, chiefly from the Broad Institute, Harvard Medical School and Boston Children's Hospital, found that a person's risk of schizophrenia is dramatically increased if they inherit variants of a gene important to «synaptic pruning» — the healthy reduction during adolescence of brain cell connections that are no longer needed.

April 17, 2013 Gene study helps understand pulmonary fibrosis A new study looking at the genomes of more than 1,500 patients with idiopathic pulmonary fibrosis, a rare and devastating lung disease, found multiple genetic associations with the disease, including one gene variant that was linked to an increase in the risk of deGene study helps understand pulmonary fibrosis A new study looking at the genomes of more than 1,500 patients with idiopathic pulmonary fibrosis, a rare and devastating lung disease, found multiple genetic associations with the disease, including one gene variant that was linked to an increase in the risk of degene variant that was linked to an increase in the risk of death.

In the case of imprinted genes, the context of crucial importance is the parental ancestry of those variants, and during the recent years there has been increasing emphasis on our need to understand how imprinting modifies genetic associations to disease.

There is brain - derived neurotrophic factor (BDNF): Some researchers suspect a variant BDNF gene might prevent hippocampal cells in the brain from functioning normally and possibly increase the risk of depression.

In the first paper, utilizing genomic analysis of nearly 8,500 Icelandic and Dutch participants, the deCODE team identified a novel, tightly - linked pair of single - letter variants (SNPs) near the ASIP (agouti signaling protein) gene on chromosome 20 that greatly increase the likelihood of an individual being prone to freckles and sunburn.