Sentences with phrase «gene variants as»

The scientists also tagged another 12 gene variants as promising candidates for further study.

Fast population growth has littered our genomes with five times as many rare gene variants as would be expected.

Not exact matches

Using a gene - sequencing technique known as whole - exome sequencing that targets only the DNA that encodes proteins, the researchers cataloged virtually every significant DNA variant in three families in which the condition is common.

But a faulty variant of this gene arose six generations ago in an Amish group, causing the people who carry one copy of the variant to produce half as much of the age - promoting protein.

As well as understanding the implications of finding this new variant of the botulism gene cluster in a non-clostridial species of gut bacterium, the team are interested in exploring how it might help in developing new treatments for diseaseAs well as understanding the implications of finding this new variant of the botulism gene cluster in a non-clostridial species of gut bacterium, the team are interested in exploring how it might help in developing new treatments for diseaseas understanding the implications of finding this new variant of the botulism gene cluster in a non-clostridial species of gut bacterium, the team are interested in exploring how it might help in developing new treatments for diseases.

A gene variant that arose decades ago in an Amish group seems to be enough to make people live ten years longer, as well as making them less likely to develop diabetes.

Their landmark findings will open the door to identify gene variants controlling skin microbiota and to define their link to various diseases such as skin inflammatory disorders.

More specifically, those with some variants of this gene will gradually produce less lactase, the enzyme that breaks down lactose, as they age.

This process known as «alternative splicing» and allowing a single gene to generate multiple protein variants is especially prevalent in the mammalian brain.

Genes also play a role in menopause, and two research teams have identified several gene variants associated with advancing or delaying menopause by as much as two years.

An apparently new Variant of human serum albumin, albumin Naskapi, has been found in high frequency in the Naskapi Indians of Quebec and, in lower frequency, in other North American Indians.The family and population data of the albumin are consistent with its inheritance as a simple autosomal trait Controlled by a gene designated Al Naskapi.

To link, at a molecular level, a gene variant with biochemical changes and clinical symptoms related to a heritable psychiatric disorder, as in this present study, is therefore something of a breakthrough.

Sophien Kamoun of the Sainsbury Laboratory in Norwich, UK, and colleagues report that P. infestans has a genome three times as large as its closest relatives, because it keeps many different variants of its «attack» genes (Nature, DOI: 10.1038 / nature08358).

We used the LD signal strength as a guide to find our way to the true risk gene — the particular variant that actually caused the increased risk for lupus.»

But as researchers pool data from thousands of cancer gene tests, some of those benign variants may be reclassified as dangerous, or may become informative in ways that hadn't been anticipated.

Because the vast majority of genes are encoded with exactly the same code, this particular code is often referred to as the canonical or standard genetic code, or simply the genetic code, though in fact there are many variant codes; thus, the canonical genetic code is not universal.

If the new combination of gene variants make the offspring better suited for growth in its current environment, that bacterium will rapidly divide asexually, outcompete its parental (or sibling) strains and become established as an emerging strain or species in its own right.

These discoveries build upon previous findings about genes linked to Alzheimer's, such as the APOE - 4 gene, which is a powerful marker for late - onset Alzheimer's disease; about 40 percent of those diagnosed have this DNA variant.

In addition to speeding up the development of brain plaques associated with Alzheimer's, a gene variant known as APOE4 also makes tau tangles — another signature of the disease — worse, researchers report online September 20 in Nature.

«We wanted to use pharmacologic means to get the same effect as the gene variant,» says Alban Latremoliere, PhD, also of Boston Children's Kirby Center, who led the current study along with Woolf and Costigan.

In several groups of people, a gene variant allowing the lactase, the enzyme breaking down the sugar in milk, to persist into adulthood became common about 5000 to 7000 years ago, when humans were herding cattle — as evidenced by this rock painting of domestic cattle in the Jebel Acacus region of the Sahara desert in Libya.

More than 85 percent had the gene variant, about as «smoking gun» of a correlation as we've seen.»

By 12 months of age, infants with this gene variant whose needs were consistently attended to responded to stress just as effectively as did the babies with other versions of the gene.

The amount of variation within any human population, however, almost overwhelms those average differences: Just about any gene variant found among the Lapps or the Malays will eventually be found in Nigerians as well.

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.

As methods for studying and comparing genetic data improve, scientists are beginning to decode these marks to reconstruct the evolutionary history of species, as well as how variants of genes give rise to unique traitAs methods for studying and comparing genetic data improve, scientists are beginning to decode these marks to reconstruct the evolutionary history of species, as well as how variants of genes give rise to unique traitas well as how variants of genes give rise to unique traitas how variants of genes give rise to unique traits.

He said: «Over the past several thousands of years, the deficiency gene seems to have been positively selected, and is mainly found in north Europe, as have gene variants for larger height and size generally.

When population geneticist Andrea Manica and graduate student Marcos Gallego Llorente at the University of Cambridge in the United Kingdom analyzed the sequence, they found that the Mota man had brown eyes and dark skin, as well as three gene variants associated with adaptation to high altitudes; some peaks in the highlands reach 4500 meters, as high as the Matterhorn.

The inherited component of breast cancer risk is due to a combination of rare variants in genes such as BRCA1 and BRCA2 that confer a high risk of the disease, and many commoner genetic variants that each confer only a small risk.

These 71 markers were found in the ANK1 and RHBDF2 genes, as well as ABCA7 and BIN1 which harbor known Alzheimer's disease susceptibility variants.

Instead, gene variants will need to be introduced by hybridization with other diverse strains of S. cerevisiae, says Borneman, such as those found in natural fermentations of African palm wine and other environmental isolates.

Analyses of such variants, compiled from cataloging the genes from more than 60,000 people, are already offering doctors helpful insights into diseases such as schizophrenia and some heart conditions.

While the outlook of patients with this gene variant is poor, these studies offer hope for a new treatment strategy for these men, and more studies are needed using next - generation androgen inhibitors, such as abiraterone and enzalutamide.

The company is looking to incorporate other genes, too, such as a gene variant that makes fruits change colour more dramatically as they ripen.

And even if such a demand existed, there was no evidence that genetic counseling could help patients with psychiatric disorders, which — like most of the more common diseases — are caused by a complex interplay of multiple genes and variants as well as environmental factors.

Now, to enable widespread gene delivery throughout the central and peripheral nervous systems, Caltech researchers have developed two new variants of a vector based on an adeno - associated virus (AAV): one that can efficiently ferry genetic cargo past the blood - brain barrier; and another that is efficiently picked up by peripheral neurons residing outside the brain and spinal cord, such as those that sense pain and regulate heart rate, respiration, and digestion.

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

As part of the International Visible Trait Genetics Consortium, he and his colleagues examined the DNA of five groups of people to see whether any particular variants of a gene were associated with each trait.

• SCT conferred a similar degree of risk as APOL1 gene variants, which are the most widely recognized genetic contributors to kidney disease in blacks.

Think of the human genome as a very large deck of cards, each card bearing a gene variant.

Gene variants that confer a survival advantage in this way can spread through a population — a process known as natural selection.

A decade ago, they also identified a relationship between ALS and excess iron accumulation when they found that 30 percent of ALS patients in their clinic carried a variant of a gene known as HFE that is associated with iron overload disease.

Engelhardt's group was responsible for mapping associations between genetic variants and gene expression levels on different chromosomes, a connection known as «trans - expression quantitative trait loci (trans - eQTLS).»

As sequencing improves, people will face the possibility of other unsavoury gene variants being spotted unexpectedly as a result of sequencinAs sequencing improves, people will face the possibility of other unsavoury gene variants being spotted unexpectedly as a result of sequencinas a result of sequencing.

The other finding was of a variant near genes for several so - called semaphorins, proteins that guide developing nerve cells as they grow toward their final targets.

As well as Zika virus, the team has also used SHERLOCK to detect antibiotic resistance genes in Klebsiella pneumoniae bacteria, and health - related gene variants in human salivAs well as Zika virus, the team has also used SHERLOCK to detect antibiotic resistance genes in Klebsiella pneumoniae bacteria, and health - related gene variants in human salivas Zika virus, the team has also used SHERLOCK to detect antibiotic resistance genes in Klebsiella pneumoniae bacteria, and health - related gene variants in human saliva.

One of their findings was a variant in a gene called Ret that had not been previously associated with the disease, although other variations in Ret had been fingered as culprits.

«GECCO aims to continue to discover additional colorectal cancer - related variants by investigating how genetic variants are modified by other environmental and lifestyle risk factors, including biomarkers as well as how they influence patient treatment response and survival,» Peters said, emphasizing how much further research is required to uncover the specific mechanisms by which genes modulate the intake of certain foods on colorectal cancer risk.

Seven of these gene variants, as expected, appeared to increase risk for both diseases.

Many more people, however, carry a low - activity variant of the gene, known as MAOA - L.