Sentences with phrase «gene variants associated»

«By analysing 18 gene variants associated with exercise and sports performance, a sport and exercise genetic test kit will help you to understand whether you are genetically better suited to endurance or power - based exercise and sport — or a mixture of the two,» says Australian company MyGene, which has developed a DIY test that comes with a 20 - page report spanning endurance, power, muscle recovery and injury risk, and recommendations for using the facts to optimise training results and minimise injury risk.

For example, genetic association studies of psychiatric disorders have located gene variants associated with the disorders, but have been able to explain only a small percentage of their heritability.

Other gene variants associated with the function of T - cells, an immune system workhorse, would later come to light.

Previous research had identified 48 gene variants associated with waist - to - hip ratio, resulting in a genetic risk score.

Now the biggest - ever genetic study of mental illness has found 128 gene variants associated with schizophrenia, in 108 distinct locations in the human genome.

Gene variants associated with GC altered promoters lack immunogenic N - terminal - lacking peptides, enhancing the ability of gastric tumours to evade the native body's immune response.

Interestingly, the team also found the spread of two gene variants associated with celiac disease.

With her expertise in handling large genetic datasets, Dr Knight helped identify the two gene variants associated with improved responses to rasagiline in early Parkinson disease (PD).

When population geneticist Andrea Manica and graduate student Marcos Gallego Llorente at the University of Cambridge in the United Kingdom analyzed the sequence, they found that the Mota man had brown eyes and dark skin, as well as three gene variants associated with adaptation to high altitudes; some peaks in the highlands reach 4500 meters, as high as the Matterhorn.

Large - scale genomic studies will probably uncover more gene variants associated with increased risk of developing PTSD, says de Quervain, and may provide a better understanding of the molecular mechanisms involved.

Genes also play a role in menopause, and two research teams have identified several gene variants associated with advancing or delaying menopause by as much as two years.

To identify gene variants associated with musical aptitude, Irma Järvelä at the University of Helsinki, Finland, and colleagues analysed the genomes of 767 people assessed for their ability to detect small differences between the pitch and duration of a sound, and musical pattern.

An estimated 40 percent of the population has the primary gene variant associated with celiac disease, but only 1 percent of people with these genes go on to develop intestinal inflammation and damage — the hallmarks of the disease — after ingesting gluten.

The Siddique and Deng lab found the UBQLN4 gene variant associated with ALS, while the Ma lab discovered the underlying disease mechanism.

Many also carry a gene variant associated with producing an overzealous immune response when exposed to pathogens.

Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial.

Testing indicated that Jolie had a gene variant associated with very aggressive form of this cancer, so she opted for a double mastectomy.

Not exact matches

Collaboration based on new findings from the Regeneron Genetics Center ® showing variant in HSD17B13 gene is associated with reduced risk of chronic liver diseases

Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening.

In this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration.

The archaic - like variants are associated with an increase in the activity of the TLR genes and with greater reactivity to pathogens.

His team found a variant near the gene associated with earlier breast development in girls and, in boys, earlier voice - breaking.

The researchers found, for example, that extraversion was associated with variants in the gene WSCD2 and near gene PCDH15; neuroticism was associated with variants on chromosome 8p23.1 and gene L3MBTL2.

They discovered that several genetic variants in the hunter - gatherers were linked to a gene associated with physical performance, which they hypothesise could be part of the physiological adaptation to cold.

The gene variant linked to graying is found only in people with European ancestry, and it has previously been associated with light hair colors.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

The celiac - associated variant of lnc13 binds poorly to these proteins, leading to increased expression of inflammatory genes.

Genes involved in mammary gland development and function had variants associated with greater milk production, perhaps indicating that the Scythians milked their horses.

«Gene variants modifying Huntington's symptom onset may lead to new therapeutic strategies: Genome - wide association analysis identifies sites associated with earlier - or later - than - expected symptom appearance in human patients.»

Certain gene variants are associated with an increased risk of disease, but MS is rarely directly inherited.

Genetic tests could one day indicate if patients are predisposed to high levels of TNF — possibly associated with the newly identified receptor gene variant — helping to identify patients that will respond to antibody therapy.

«In the current study, we analyzed dozens of variants of those genes and other genes frequently associated with obesity risk and saw that, while total fat intake was related to higher BMI, people who were genetically predisposed to obesity and ate the most saturated fat had the highest BMIs.»

Gusella explains that the presence of two modifying variants on chromosome 15 — one associated with symptoms appearing an average of six years early, the other associated with an average one - and - a-half-year delay — implies that there may be two actual modifying variants that both influence one modifier gene but in opposite directions.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

Alzheimer's - Of the three variants of the ApoE gene, ApoE4 carries the highest risk for late - onset Alzheimer's (other genes are associated with early - onset Alzheimer's).

In addition to speeding up the development of brain plaques associated with Alzheimer's, a gene variant known as APOE4 also makes tau tangles — another signature of the disease — worse, researchers report online September 20 in Nature.

The group has also shown that in humans, genetic variants of the Oprl1 gene are associated with higher risk of developing the disorder after exposure to trauma.

McRae and colleagues found that the genetic variants associated all lie in or near genes that encode so - called odorant or olfactory receptors.

Having just one copy of a particular variant of a gene called CREBRF is associated with a 1.5 increase in BMI.

We identify previously uncharacterized genes and variants associated with skin pigmentation in ethnically diverse Africans.

«Gene variant explains racial disparities in adverse reactions to urate - lowering drug: Findings support screening for risk - associated variant in Asian, black patients with gout.»

Two variants stood out, the most significant associated with the gene for GDF15 and the second with a gene for a protein called IGFBP7.

The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.

Earlier, smaller studies had associated the three gene variants with type 2 diabetes.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

Among the gene variants modern humans inherited from Neandertals are ones associated with higher cholesterol, increased belly fat, rheumatoid arthritis and schizophrenia, researchers learned from analysis of the new Neandertal DNA.

Interestingly, a variant of the WNT10A gene associated with lower levels of its protein's expression has been linked to a greater likelihood of male pattern baldness, according to a recent genome - wide association study.

«Financial stress is associated with migraine, if you have specific circadian gene variants.»

Three simultaneous reports involving more than 32,000 participants uncovered four new diabetes - associated gene variants, bringing to 10 the number of known non-Mendelian genetic risk factors for type 2 diabetes.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.