Sentences with phrase «gene variants for»

Where the Neanderthal had gene variants for a larger skull, for instance, Church would use MAGE to modify the nucleotide sequences that constituted those genes in one or more of the chunks of human DNA.

Given that the gene variants for diabetes may remain elusive for a while, Tuomilehto has concentrated on the environmental aspects of the disease.

He said: «Over the past several thousands of years, the deficiency gene seems to have been positively selected, and is mainly found in north Europe, as have gene variants for larger height and size generally.

Examples include modern human gene variants for cognitive development.

The researchers also discovered that the great tits carrying the gene variant for longer beaks were more successful in raising their chicks to fledglings than birds without it.

The gene variant for white colour in pigs differs from the gene variant found in wild boar, with at least five different mutations, four of which are duplications of DNA sequences.

Not exact matches

Athletigen's process involves taking a sample of an athlete's saliva and subjecting it to genotyping analysis to search for 850,000 different gene variants that may play a role in the formation of athletic traits.

«Those carrying the target gene variant slept, on average, for five hours, which was one hour shorter than their twins without the gene.

These genes are implicated in highly penetrant genetic disorders for which surgical or other interventions aimed at preventing or significantly reducing morbidity and mortality are available to pathogenic variant carriers.5 Identification of a pathogenic variant in one of these genes could be diagnostic of a medical condition with potential implications for an individual's medical management.

For those who have MTHFR gene variants, supplemental folic acid has not been found to reduce the risk of miscarriage.

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

The genetic shift introduced variants for paler skin and lighter - colored eyes; genes for digesting lactose became common sometime later.

For their experiments, the researchers created hybrids of two genetically distinct mouse strains with a fully sequenced genome, allowing gene variants to be clearly assigned to the maternal or paternal allele.

Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening.

To identify gene variants associated with musical aptitude, Irma Järvelä at the University of Helsinki, Finland, and colleagues analysed the genomes of 767 people assessed for their ability to detect small differences between the pitch and duration of a sound, and musical pattern.

As well as understanding the implications of finding this new variant of the botulism gene cluster in a non-clostridial species of gut bacterium, the team are interested in exploring how it might help in developing new treatments for diseases.

The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

Friedrich and his colleagues analyzed the genes of these variant viruses in their new study; no new ferret experiments were performed for the new analysis.

«For 20 years we've been looking for the gene and mutation behind my family's neuropathy, but we never found the variant,» he saFor 20 years we've been looking for the gene and mutation behind my family's neuropathy, but we never found the variant,» he safor the gene and mutation behind my family's neuropathy, but we never found the variant,» he says.

The researchers found, for example, that extraversion was associated with variants in the gene WSCD2 and near gene PCDH15; neuroticism was associated with variants on chromosome 8p23.1 and gene L3MBTL2.

That does not mean that breeders could create a 200 - pound Chihuahua by swapping the small IGF1 variant for another, she says, because multiple genes work together to shape a breed's traits, including its size.

In Huntington's disease, mice carrying the pathologic genetic variant of the huntingtin gene are being used to understand how this genetic lesion causes degeneration of striatal neurons and to develop novel treatments for the illness.

We used the LD signal strength as a guide to find our way to the true risk gene — the particular variant that actually caused the increased risk for lupus.»

The IGF1 protein is crucial for the growth of mammals, including mice and humans, so Ostrander's group and other collaborators began collecting DNA from additional breeds to see if they also shared the same gene variant.

In general, more than 70 percent of schizophrenia cases are sporadic versus familial — so many patients have variants of influential genes that have occurred in them for the first time.

Dr Antonio Pardiñas, first author of the study, said: «We show for the first time that genetic variants that do not severely impact gene function, but presumably have a more subtle impact on these critical genes, increase risk for developing schizophrenia.»

We did not find any evidence for a so - called «positive selection» but instead found that many gene variants linked to schizophrenia reside in regions of the genome in which natural selection is not very effective in the first place.

Other gene variants — like mutations in FTO or the gene for leptin, an energy - balancing hormone — had been linked to overeating or fat cell type.

«Our finding from statistical analyses of all genes in the genome that SMCHD1 was the only plausible site of causal variants for arhinia — lack of a nose — was frankly shocking, since prior to our study no patients had ever been reported with both conditions.»

So scientists can now use the so called gene chips to scan people's DNA for hundreds of thousands of genes and different variants of genes.

If the new combination of gene variants make the offspring better suited for growth in its current environment, that bacterium will rapidly divide asexually, outcompete its parental (or sibling) strains and become established as an emerging strain or species in its own right.

Gene variants common in people of Asian and European ancestry, for instance, make them more prone than those of African origin to developing severe dengue shock syndrome, according to a new study in PLOS Neglected Tropical Diseases.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

Alzheimer's - Of the three variants of the ApoE gene, ApoE4 carries the highest risk for late - onset Alzheimer's (other genes are associated with early - onset Alzheimer's).

These discoveries build upon previous findings about genes linked to Alzheimer's, such as the APOE - 4 gene, which is a powerful marker for late - onset Alzheimer's disease; about 40 percent of those diagnosed have this DNA variant.

Using genetic data from more than 36,000 people with a variety of autoimmune diseases, researchers found that one genetic variant in the gene that codes for the TYK2 protein...

All land vertebrates carry a version of the FOXP2 gene, so some of the Oxford researchers then teamed up with colleagues from the Max Planck Institute for Evolutionary Anthropology in Germany to analyze what is unique about the variant in humans and to track how the gene had evolved in our ancestors.

Gene variants have been linked to elevated risks for disorders from Alzheimer's disease to breast cancer, and they may help explain why, for example, some smokers develop lung cancer whereas many others don't.

We screened a total of 394 Amish research subjects for the KCNH7 mutation; 84 of these individuals carried at least one copy of the gene variant, and the lifetime incidence of bipolar spectrum disorders among them was 49 percent (41 people were affected with the disease).

Medical researchers have used DNA sequencing to identify a gene variant responsible for causing lupus in a young patient.

Evolutionary biologists have long wondered why genetic variation is maintained, when there should be a «best» variant for each gene.

And almost 90 percent of urban swans had the same variant of a gene for dopamine transport, while just 60 percent of rural birds had that version.

«Gene variant explains racial disparities in adverse reactions to urate - lowering drug: Findings support screening for risk - associated variant in Asian, black patients with gout.»

They then examined genetic variants throughout the human genome for their effects on gene expression in these two representative populations of immune cells.

Two variants stood out, the most significant associated with the gene for GDF15 and the second with a gene for a protein called IGFBP7.

But some of the babies did not show this normal decrease in vagal tone during distressing periods; the researchers found that these infants who lacked an effective response at ages three and six months shared a particular variant of the DRD2 gene, which regulates receptors for the neurotransmitter dopamine.

The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.

As methods for studying and comparing genetic data improve, scientists are beginning to decode these marks to reconstruct the evolutionary history of species, as well as how variants of genes give rise to unique traits.

To determine which variant of the receptor genes study participants possess, DNA was collected via saliva samples for genetic analysis.

For example, researchers reported in a much touted 2006 Science article that they had discovered a gene variant that seemed to confer a risk for obesity, and they replicated the results in four human populatioFor example, researchers reported in a much touted 2006 Science article that they had discovered a gene variant that seemed to confer a risk for obesity, and they replicated the results in four human populatiofor obesity, and they replicated the results in four human populations.