Sentences with phrase «gene variants in»

Mekile says she plans to use her award to establish a link between gene variants in patients and autism - like neurological disorders.

Prüfer and her team additionally identified a wealth of new gene variants in the Neanderthal genome that are influential in people today of European and Asian heritage.

Freedman, B. I., et al. «Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure.»

As well as Zika virus, the team has also used SHERLOCK to detect antibiotic resistance genes in Klebsiella pneumoniae bacteria, and health - related gene variants in human saliva (Science, DOI: 10.1126 / science.aam9321).

As well as Zika virus, the team has also used SHERLOCK to detect antibiotic resistance genes in Klebsiella pneumoniae bacteria, and health - related gene variants in human saliva.

«Using a technique developed by our collaborators at the University of Iowa, we were able to get long - term expression of these human gene variants in the fluid that bathes the entire brain,» says Bradley Hyman, MD, PhD, of the MassGeneral Institute for Neurodegenerative Disease (MGH - MIND), senior author of the report in the Nov. 20 Science Translational Medicine.

What we need to do now is to see if other circadian gene variants in association with different stress factors cause the same effect.

The researchers replicated these three PKC alpha gene variants in laboratory cell lines.

In this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration.

But they found the same gene variant in the genome of a Denisovan, an extinct species of human known only from a cave in the Altai mountains in east - central Asia (Nature, DOI: 10.1038 / nature13408).

These scientists studied whether a gene variant in the FTO gene, which regulates the appetite and thereby increases the individual's BMI, is also linked to a series of cardiovascular diseases and metabolism.

For example, a particular gene variant in the promoter region of the IL10 gene is associated with a 40 to 60 % increased risk of developing active tuberculosis among Europeans and Americans [75].

Earlier, this geneticist at the University of California, Berkeley, had looked for the source of the Tibetan gene variant in other peoples.

In 2002, two groups identified a particular gene variant in the major histocompatibility complex (MHC), called HLA - B * 5701, as being the key factor in hypersensitivity to abacavir.

Not exact matches

To illustrate how it works in practice, Koenig offers the example of a professional hockey player whose profile shows that he has gene variants found in people who respond rapidly to lactic - acid threshold training.

Athletigen's process involves taking a sample of an athlete's saliva and subjecting it to genotyping analysis to search for 850,000 different gene variants that may play a role in the formation of athletic traits.

Collaboration based on new findings from the Regeneron Genetics Center ® showing variant in HSD17B13 gene is associated with reduced risk of chronic liver diseases

These genes are implicated in highly penetrant genetic disorders for which surgical or other interventions aimed at preventing or significantly reducing morbidity and mortality are available to pathogenic variant carriers.5 Identification of a pathogenic variant in one of these genes could be diagnostic of a medical condition with potential implications for an individual's medical management.

This team also discovered 3,200 genes that had fewer loss - of - function or missense mutations than would be expected suggesting that these are likely disease - causing variants that are rare or absent in the population because of their detrimental effect on human health.

What the figure shows is that in small populations, genetic diversity is rapidly lost, that is, gene variants (i.e. alleles) become «fixed.»

Some researchers have looked into what role genes might have in our tendency to cheat, like last year's study on a certain variant of the dopamine gene DRD4 — and dopamine is the force behind our sexual drives, survival needs and pair - bonding behaviors.

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk

Genetic Variants of the FADS1 FADS2 Gene Cluster Are Associated with Altered (n - 6) and (n - 3) Essential Fatty Acids in Plasma and Erythrocyte Phospholipids in Women during Pregnancy and in Breast Milk during Lactation

Using a gene - sequencing technique known as whole - exome sequencing that targets only the DNA that encodes proteins, the researchers cataloged virtually every significant DNA variant in three families in which the condition is common.

In 2008, researchers linked variants in the gene to the strong, frightful reaction some people have to horror movieIn 2008, researchers linked variants in the gene to the strong, frightful reaction some people have to horror moviein the gene to the strong, frightful reaction some people have to horror movies.

No particular genetic variant was shared across all synesthetes in all three families, suggesting there is no single «synesthesia gene» or set of genes.

Every gene in (almost) every cell of the body is present in two variants — so called alleles: one is deriving from the mother, the other one from the father.

These are subjected to so - called next generation sequencing, a technique that sifts the vast genetic composite, ferreting out sequence variants (or alleles) caused by mutations in genes.

But a faulty variant of this gene arose six generations ago in an Amish group, causing the people who carry one copy of the variant to produce half as much of the age - promoting protein.

Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening.

A large - scale genetic study published in The Lancet in 2012 found no relationship between gene variants that increased HDL and the likelihood of heart attack (though this research did not evaluate the SCARB1 variants).

As well as understanding the implications of finding this new variant of the botulism gene cluster in a non-clostridial species of gut bacterium, the team are interested in exploring how it might help in developing new treatments for diseases.

A gene variant that arose decades ago in an Amish group seems to be enough to make people live ten years longer, as well as making them less likely to develop diabetes.

In fact, the MESA researchers had included 46 different variants of the gene in their sequencing databasIn fact, the MESA researchers had included 46 different variants of the gene in their sequencing databasin their sequencing database.

The archaic - like variants are associated with an increase in the activity of the TLR genes and with greater reactivity to pathogens.

The results, still in a preliminary stage, show that patients with a specific variant in the RET gene - a proto - oncogene or cancer driver gene; variant G2071A - could be more sensitive to this drug.

The researchers looked at a type of genetic change called copy number variants, which refers to the number of copies of genes in human DNA.

In humans, there are three common variants, or alleles, of the APOE gene, numbered 2, 3 and 4.

His team found a variant near the gene associated with earlier breast development in girls and, in boys, earlier voice - breaking.

The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

This process known as «alternative splicing» and allowing a single gene to generate multiple protein variants is especially prevalent in the mammalian brain.

Friedrich and his colleagues analyzed the genes of these variant viruses in their new study; no new ferret experiments were performed for the new analysis.

Variants of one gene had a major effect on rapid changes in beak size after a drought, researchers report in the April 22 Science.

«Now, we know that epigenetic factors accumulate at a very different pace in each person, depending on the genetic variants of the lactase gene.»

In 2010, they discovered a common gene variant that predicts efficacy of the common anti-platelet medication, clopidogrel (Plavix ®).

Genes also play a role in menopause, and two research teams have identified several gene variants associated with advancing or delaying menopause by as much as two years.

In the journal Cell on July 27, researchers show how this DNA variant enhances the activity of a gene called endothelin - 1 (EDN1), which is known to promote vasoconstriction and hardening of the arteries.

All four teams focused their hunts on gene variations found in at least 10 per cent of the population, while Stefánsson thinks that rarer variants may play a more significant role in menarche.

An apparently new Variant of human serum albumin, albumin Naskapi, has been found in high frequency in the Naskapi Indians of Quebec and, in lower frequency, in other North American Indians.The family and population data of the albumin are consistent with its inheritance as a simple autosomal trait Controlled by a gene designated Al Naskapi.