Sentences with phrase «gene variants into»

Studying a specific type of genetic variation in the DNA sequences of wolves and domestic dogs - called Single Nucleotide Polymorphisms (SNPs)- the scientists identified the transfer of dog gene variants into wolf genomes.

Might mating between an ancient human and a Neanderthal - perhaps occurring in only a single instance - have introduced a gene variant into the human population that enhanced human brain function?

Not exact matches

Some researchers have looked into what role genes might have in our tendency to cheat, like last year's study on a certain variant of the dopamine gene DRD4 — and dopamine is the force behind our sexual drives, survival needs and pair - bonding behaviors.

We show that Neandertals shared more genetic variants with present - day humans in Eurasia than with present - day humans in sub-Saharan Africa, suggesting that gene flow from Neandertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.

In several groups of people, a gene variant allowing the lactase, the enzyme breaking down the sugar in milk, to persist into adulthood became common about 5000 to 7000 years ago, when humans were herding cattle — as evidenced by this rock painting of domestic cattle in the Jebel Acacus region of the Sahara desert in Libya.

The new test uses a highly sensitive gene mutation detection method that is based on the partitioning of DNA into droplets to detect specific circulating tumor DNA mutations and RNA variants in whole blood.

By splicing the scrambled genes into Escherichia coli bacteria and growing the new strains in colonies, he and his colleagues identified variants that glow like GFP.

Then they inserted the IGPS variants into bacteria whose PRAI genes had been knocked out.

By characterising the DNA sequence of these individuals, the project gained insight into the contribution of rare variants to a broad range of disease scenarios, and discovered new genetic variants and genes underpinning disease risk.

While previous investigations into the protein's effects have used either mice in which gene expression was knocked out or transgenic animals that expressed human gene variants throughout their lifetimes, the MGH - MIND - led study used a different approach to investigate the effects of introducing the variant forms of the protein into brains in which plaque formation had already begun.

They directly injected into the cerebrospinal fluid of a mouse model of Alzheimer's — adult animals in which plaques were well established — viral vectors carrying genes for one of the three APOE variants or a control protein.

Once transferred into the human genome, however, these alleles became subject to natural selection, which was more effective in the larger human populations and has removed these gene variants over time.

Analyses of such variants, compiled from cataloging the genes from more than 60,000 people, are already offering doctors helpful insights into diseases such as schizophrenia and some heart conditions.

Hendrik is preparing the publication of the most complete woolly mammoth genome yet, and Harvard geneticist George Church's team is already working to introduce specific DNA variants — genes for hair, tusks, subcutaneous fat and cold resistance — into cultured cells from Asian elephants (right).

«We hope that our findings will foster development of a personalized strategy for the prevention and treatment of multiple sclerosis, one that takes into account the gender - specific contribution of galanin gene variants to susceptibility and disease progression,» said Dr. Victoria Lioudyno, lead author of the study.

Different versions of the FRO2 gene («variants») fell into two groups, those that were associated with a short root and those that were associated with a long root.

Among infants with neonatal abstinence syndrome (NAS; caused by in utero opioid exposure), variants in certain genes were associated with a shorter length of hospital stay and less need for treatment, preliminary findings that may provide insight into the mechanisms underlying NAS, according to a study in the May 1 issue of JAMA, a theme issue on child health.

Instead of using the traditional method of introducing genetic mutations into mice to create «knockout» mice — or animals with customized genes — they found they were able to find naturally occurring variants among animals in the wild.

These mutations are inserted into batches of yeast or bacterial cells, which express the altered gene and produce millions of random protein variants.

Reykjavik, ICELAND, 12 October 2011 — deCODE genetics today announced that it has entered into a research collaboration with Pfizer Inc., the objective of which is to discover sequence variants associated with specific clinical phenotypes related to Systemic Lupus Erythematosis by utilizing deCODE's expertise in gene discovery.

Already, the genome's tales are revealing how genetic variants contribute to disease, giving researchers insights into human evolution and even changing how scientists define a gene.

The theory and approaches of aggregation testing are too broad a topic to cover here, but the general concept is this: by grouping individual rare variants into a biological unit — most often, a gene or exon — it's possible to test the super-genotype (i.e. «has a rare variant in gene A») for association.

We report the integration of transcriptome sequencing (RNA - seq), which surveys all mRNAs to reveal functional impacts of variants at the transcription level, into the gene discovery framework for a unique human disease, microcephaly - micromelia syndrome (MMS).

In addition, the data reveal that this was a more genetically diverse population than the central and western European hunter - gatherers living during the same epoch and that they also show pattern of adaptation to high latitude environments, including high frequencies of low pigmentation variants as well as a gene region associated with physical performance, which shows strong continuity into modern - day northern Europeans.

Human DNA sequence variants that truncate the CETP gene may provide insight into the efficacy of CETP inhibition.

This program has resulted in the discovery of unique variants in environmentally responsive genes, the development of a number of resources, and capacity building in the environmental epidemiology communities in order to incorporate gene - environment hypotheses and tools into human population - based studies on a number of environmentally relevant diseases.

Recent research into a field of science called nutrigenomics makes it safe and easy to use a simple home kit to examine your genes for the presence of particular variants that predispose you to weakness in detoxification, Vitamin D metabolism, antioxidant processing, other nutrient imbalances and certain conditions, such as obesity, hypertension, diabetes and cardiovascular disease.