Sentences with phrase «gene variants on»

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution.

Not exact matches

The company will now be able to sell health risk reports on three variants found on the BRCA1 and BRCA2 genes, which are linked with a higher risk of breast, ovarian, and prostate cancer.

«Those carrying the target gene variant slept, on average, for five hours, which was one hour shorter than their twins without the gene.

Collaboration based on new findings from the Regeneron Genetics Center ® showing variant in HSD17B13 gene is associated with reduced risk of chronic liver diseases

This team also discovered 3,200 genes that had fewer loss - of - function or missense mutations than would be expected suggesting that these are likely disease - causing variants that are rare or absent in the population because of their detrimental effect on human health.

Some genes have a variety of different forms, which are located at the same position on a chromosome; an allele is such a variant form of a gene.

Some researchers have looked into what role genes might have in our tendency to cheat, like last year's study on a certain variant of the dopamine gene DRD4 — and dopamine is the force behind our sexual drives, survival needs and pair - bonding behaviors.

Researchers have assumed that mothers are more likely to pass on autism - promoting gene variants.

Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening.

Variants of one gene had a major effect on rapid changes in beak size after a drought, researchers report in the April 22 Science.

«Now, we know that epigenetic factors accumulate at a very different pace in each person, depending on the genetic variants of the lactase gene.»

In the journal Cell on July 27, researchers show how this DNA variant enhances the activity of a gene called endothelin - 1 (EDN1), which is known to promote vasoconstriction and hardening of the arteries.

All four teams focused their hunts on gene variations found in at least 10 per cent of the population, while Stefánsson thinks that rarer variants may play a more significant role in menarche.

«So, a variant of gene with a positive effect on intelligence, has a negative effect on schizophrenia, body mass index or obesity.»

The researchers found, for example, that extraversion was associated with variants in the gene WSCD2 and near gene PCDH15; neuroticism was associated with variants on chromosome 8p23.1 and gene L3MBTL2.

Fat genes like the FTO variant, however, make it harder to stay on track and keep weight down.

On the other hand, gene variants that confer a benefit to males are more likely to accumulate on the X chromosome than on a nonsex chromosome because they will always be expressed on a male's single X chromosomOn the other hand, gene variants that confer a benefit to males are more likely to accumulate on the X chromosome than on a nonsex chromosome because they will always be expressed on a male's single X chromosomon the X chromosome than on a nonsex chromosome because they will always be expressed on a male's single X chromosomon a nonsex chromosome because they will always be expressed on a male's single X chromosomon a male's single X chromosome.

Dr Antonio Pardiñas, first author of the study, said: «We show for the first time that genetic variants that do not severely impact gene function, but presumably have a more subtle impact on these critical genes, increase risk for developing schizophrenia.»

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

An estimated 40 percent of the population has the primary gene variant associated with celiac disease, but only 1 percent of people with these genes go on to develop intestinal inflammation and damage — the hallmarks of the disease — after ingesting gluten.

Gusella explains that the presence of two modifying variants on chromosome 15 — one associated with symptoms appearing an average of six years early, the other associated with an average one - and - a-half-year delay — implies that there may be two actual modifying variants that both influence one modifier gene but in opposite directions.

Having only one variant copy of the gene gives people the appearance of looking about one year older on average, the team of Dutch and British researchers concluded.

About 4 percent of people in the study carried one of these two rare variants, which are located in the vicinity of the MGST1 gene on chromosome 12.

In 2011, Science's editors will be watching a smaller detector at the Large Hadron Collider called LHCb, which will study B mesons in great detail; new techniques that should lead to the discovery of many more genes contributing to adaptation; an ignited fusion burn at the National Ignition Facility; broadly neutralizing antibodies, which are capable of disabling a wide range of viral variants; the first plug - in hybrid electric cars whose batteries are charged from a wall socket go on the market; and the results of the first phase III trial of a malaria vaccine.

The new test uses a highly sensitive gene mutation detection method that is based on the partitioning of DNA into droplets to detect specific circulating tumor DNA mutations and RNA variants in whole blood.

They then examined genetic variants throughout the human genome for their effects on gene expression in these two representative populations of immune cells.

Five decades on from the appearance of the first MRSA, multiple MRSA lineages have emerged which have acquired different variants of the resistance gene.»

The authors found that in children with a genetic variant in the vitamin D receptor gene, vitamin D levels in infancy and childhood were lower in those that went on to develop islet autoimmunity compared with those that did not develop autoimmunity.

The study, which has identified more than 200 rare variants inherited by children, determines that genes YWHAZ and DRP2, among others, are new candidates in the research on autism genetic basis.

Males who carried a particular variant of the IGF2R gene had significantly lower IQs overall, although Jirtle could not predict any individual's score based on genes.

Gene variants that improve the animal's ability to adapt to that new environment can then be selected for, and passed on to its progeny.

The new study focused on 40 cognitively healthy older adults between the ages of 65 and 75 who are carriers of a gene variant (APOE e4) that is known to contribute to the risk of developing late - onset Alzheimer's disease.

Now, to enable widespread gene delivery throughout the central and peripheral nervous systems, Caltech researchers have developed two new variants of a vector based on an adeno - associated virus (AAV): one that can efficiently ferry genetic cargo past the blood - brain barrier; and another that is efficiently picked up by peripheral neurons residing outside the brain and spinal cord, such as those that sense pain and regulate heart rate, respiration, and digestion.

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

In fact, in another study published last year, National Institute on Aging (NIA) researchers discovered that people with what's called a CR1 gene variant — the presence of which heightens Alzheimer's disease risk — had much lower levels of amyloid protein compared with those without the mutant gene.

With this knowledge we can not only improve yield and quality but also improve animal health by identifying pathogenic gene variants and ensuring that they are not passed on to future animals.»

Today most East Asians and nearly all Koreans lack a chemical in their armpits that bacteria munch on to make body odor, because they carry this variant of the ABCC11 gene.

Given that the gene variants for diabetes may remain elusive for a while, Tuomilehto has concentrated on the environmental aspects of the disease.

«There are no common variants with large effects,» says Lavinia Paternoster, a geneticist at the University of Bristol in the United Kingdom, who plans to work with Kayser in the future on finding more facial genes.

The work, which uncovers a new class of genetic variants that modulate gene expression, is published on Nature Genetics's Advance Online Publication website on December 7.

«At this stage, it is unclear how many people with ALS have the UBQLN4 gene variant, and this will be important to determine,» says Ma, the senior author on the study who is Ann Marie and Francis Klocke, MD Research Scholar at the Manne Research Institute and Assistant Professor at Northwestern University Feinberg School of Medicine.

«How a drug is going to work on a carrier of the gene variant could be worse or it could be better, but it's likely going to be different,» Connor said.

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

Engelhardt's group was responsible for mapping associations between genetic variants and gene expression levels on different chromosomes, a connection known as «trans - expression quantitative trait loci (trans - eQTLS).»

A study published on December 11th in PLOS Pathogens reports that genetic variants in a gene called IL - 28B influence influenza vaccine responses.

GenProfile focuses on the systematic analysis of DNA sequence variation in biomedically relevant genes in order to identify those variants, or combinations of variants (gene profiles), that determine an individual's genetic risk for disease, predict individually different drug response, and ultimately pave the way to a personalized medicine.

«GECCO aims to continue to discover additional colorectal cancer - related variants by investigating how genetic variants are modified by other environmental and lifestyle risk factors, including biomarkers as well as how they influence patient treatment response and survival,» Peters said, emphasizing how much further research is required to uncover the specific mechanisms by which genes modulate the intake of certain foods on colorectal cancer risk.

«This research is an important addition to the field because previous studies looking at CYP gene variants and their effects on risks of repeat heart attacks, bleeding and death have included predominantly Caucasian patients of European ancestry,» Cresci noted.

By focusing on several of these mutations and screening through guide RNA variants with different mismatch combinations, they were able to identify specific guide RNAs that stimulated Cas9 activity towards the mutated gene sequences but left the normal counterpart untouched.

Among infants with neonatal abstinence syndrome (NAS; caused by in utero opioid exposure), variants in certain genes were associated with a shorter length of hospital stay and less need for treatment, preliminary findings that may provide insight into the mechanisms underlying NAS, according to a study in the May 1 issue of JAMA, a theme issue on child health.