Sentences with phrase «gene variation affect»

Not exact matches

But over the past decade, researchers have identified hundreds of gene variations that seem to affect brain development in ways that increase the risk of autism.

«It's sort of the tip of the iceberg,» says Uitterlinden, who led one of four groups that identified several variations in a gene called LIN28B that affect the timing of girls» first period, or menarche.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

Next, he synthesised 50,000 DNA strands with sequences that almost matched parts of the 24 genes involved in lycopene production, but with a range of variations that he hoped would affect the amount of lycopene produced.

Variations in the PKCA gene and reports of emotionally affecting photos among 700 health young volunteers confirm hypotheses about the core role of memory in PTSD

«Single gene variation linked to obesity: Variation in the BDNF gene may affect brain's regulation of appetite, study suggestvariation linked to obesity: Variation in the BDNF gene may affect brain's regulation of appetite, study suggestVariation in the BDNF gene may affect brain's regulation of appetite, study suggests.»

By studying rare «copy number variations,» which are individual errant insertions or deletions of DNA segments (each of which occur in less than one percent of the population), researchers discovered a new cluster of genes that are affected in some autistic individuals as well as a number of mutations that were present in autistic children but not their parents.

Only about 10 percent of this variation can be attributed to genes known to affect pigmentation.

Researchers studying two generations of a family affected by pediatric acute lymphoblastic leukemia (ALL) have identified an inherited variation in the ETV6 gene that is associated with an increased risk of developing the disease.

Although previous research has identified genes involved with behaviors seen in eating disorders such as anorexia or bulimia, little is known about how natural variation in these genes could affect eating behaviors in healthy people.

Mutations affecting adult haemoglobin production are among the most common of all genetic variations, with about 5 per cent of the world's population carrying a defective gene.

In the study, they additionally confirmed that nearby genetic variation in the form of cis - eQTLs affected expression of about 50 percent of genes in the samples.

In contrast, cis - eQTLs — which account for the majority of genetic variation that affects gene expression — regulate genes located nearby on the same chromosome.

They found that 10 per cent of these children have copy number variations (CNVs) affecting genes deemed clinically relevant.

Geneticists classify traits like tooth size and shape as «complex» because they are affected by DNA variations within many genes.

Studies of worms and fruit flies show that variations, or polymorphisms, in a single gene can affect how long these creatures live.

Overall, the new study suggests that genetic variations in the gene that codes for POU6F2 may affect the structure of the eye and increase a person's risk of glaucoma, but additional studies will be needed to describe the exact mechanism.

Human traits like hair distribution, fatness and fat distribution, blood chemistry, and ear form are known to be affected by variation in dozens or hundreds of genes.

I found that negative selection against new mutations and positive selection for new mutations shape broad patterns of genomic variation and that much of the genomic variation that actually affects gene expression is under negative selection.

In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.

Professor Segal's research has two major directions 1) Gene regulation — using quantitative and computational models to understand how DNA sequence variation among human individuals generates phenotypic diversity 2) Microbiome and Nutrition — understanding how the microbial composition of individuals affect their physiology and health.

The finding that bsl1 - 1 and bsl1 - 2 fail to complement and have SNP variation affecting dramatic changes in the coding capacities of the same gene demonstrate that loss of Sevir.7 G140700 function is responsible for the bsl1 mutant phenotypes.

The study also demonstrates an association between NCAN variations with volumes of certain brain regions in young adults and infants, suggesting that the gene is able to affect brain structure and function.

She has pioneered the intergration of large - scale genome and transcriptome sequencing data to understand how genetic variation affects gene expression, providing insight to cellular mechanisms underlying genetic risk for disease.

Our first striking observation was that over one half of measured genes are affected by common genetic variation in human populations — called expression quantitative trait loci or eQTLs.

Most of the DNA variations in AMD patients are found outside of the genes, and it is extremely hard to know whether these variants are actual mutations and what genes they affect.

This work provides a foundation for further studies on how genetic variation in the identified genes could affect the fitness of oyster populations subjected to environmental changes, such as ocean acidification.

These small differences in DNA sequence, or genetic variation, may or may not affect gene function.

Many medical - genetic syndromes show a clear connection between genetic alteration and typical facial gestalt [49], hence genes involved in affected individuals may also contribute to normal variations in facial shape.

386/11: 15 Clinical indexing genes affected by copy number variation in neurodevelopmental disorders.

«GTEx will begin to provide researchers with a comprehensive view of genetic variation and a more precise understanding of how it affects genes critical to the normal function of tissues and organs,» said NIH Director Francis S. Collins, M.D., Ph.D. «This resource will add a new dimension to our understanding of human biology and the mechanisms that lead to disease.»

However, gene variations, the presence of strain - specific genes, and the occurrence of plasmids in strain GP59 could affect the expression pattern of these common genes.

The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.

Centenarians may live such extraordinarily long lives in large part due to genetic variations that either affect the rate of aging and / or have genes that result in decreased susceptibility to age - associated diseases.

A variation of the gene PDSS2 also affects speed of metabolism.

It's important to test for both homocysteine levels and the MTHFR gene variation because while you may not have the gene that affects the methylation pathways, you may still have elevated homocysteine levels, which tells us the level of inflammation in our bodies.

A 2014 study from UC Berkley that found that long - term marital satisfaction over time can be affected based on the different variations of this gene that people have.

This means that 28 to 40 percent of the variation between affected and unaffected relatives is due to genes.

Although the study of psychological genetics is in its infancy and much is still to be learned, in this article, we present data suggesting that variation in several genes known to affect brain function appear to influence the degree to which one is emotionally responsive to the social environment.

In relation to the association of infant attachment with a promoter polymorphism of the serotonin transporter gene, we have mentioned that gene expression may be affected by variation in the DNA sequence of the regulatory region of the gene.

Early life adversity and serotonin transporter gene variation interact to affect DNA methylation of the corticotropin - releasing factor gene promoter region in the adult rat brain