Sentences with phrase «gene variation linked»

«Inherited gene variation linked to an increased risk of the most common childhood cancer.»

«Single gene variation linked to obesity: Variation in the BDNF gene may affect brain's regulation of appetite, study suggests.»

Not exact matches

After gene - typing about 3,000 people, Sturm found that how OCA2 is expressed — and how much pigment a person has — is strongly linked to three single nucleotide polymorphisms (SNPs), or single letter variations, in a DNA sequence near the OCA2 gene.

The researchers found that adolescents who had a variation of another gene, which contributes to how quickly serotonin is recycled in the brain and which has been linked to hostile behavior in children, were more likely to exhibit signs of psychopathy.

From this research, Loos found that fatness was significantly linked to variations in the FTO gene and a gene called IRS1.

Trent and others says that the same mechanism might be at work in genes linked to other cancers, such as breast and prostate cancer, which have been found to contain similar «harmless» sequence variations.

The study, conducted using fruit fly populations bred to model natural variations in human sleep patterns, provides new clues to how genes for sleep duration are linked to a wide variety of biological processes.

The research was also the first to consider whether variation in the burn receptor gene might influence alcohol sensations, which has not previously been linked to alcohol consumption.

In a large study, researchers have linked small variations in three genes to type 2 diabetes.

Genes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the ArGenes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Argenes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Arctic.

Researchers have discovered that protection from the most severe form of malaria is linked with natural variation in human red blood cell genes.

«Natural resistance to malaria linked to variation in human red blood cell receptors: First study to identify protective effect of glycophorin gene rearrangements on malaria.»

«Surprisingly, when we looked for shared gene variants that might help explain part of the link between migraine and heart disease, we found no shared gene variations between migraine with aura and heart disease,» said study author Aarno Palotie, MD, of the Broad Institute of MIT and Harvard.

A recent study linking schizophrenia and variations of the gene C4 also implicates the pathway involved in synaptic pruning.

«These findings are extremely important,» says political scientist James Fowler at the University of California, San Diego, who has been doing research linking certain gene variations to political activity.

A dopamine - receptor gene variation is linked to changes in brain function, possibly neurotransmitter signaling

So when Drake and his colleagues measured the RNA levels — a direct link to how much of a gene is being produced — in the genes of 334 mice, he didn't expect to find more than a few variations that might help explain why males and females have such different rates of cardiovascular disease and diabetes or why they react differently to certain drugs.

Although variations in the NPAS1 and NPAS3 genes have been linked to brain disorders including autism, they aren't obvious drug targets because their function is most important in early life.

Covering the entire genome, the study discovered that a common variation in the melatonin receptor 1A (MTNR1A) gene is linked to the job - related exhaustion experienced by shift workers.

University researchers have identified a link between injury to the developing brain and common variation in genes associated with schizophrenia and the metabolism of fat.

«Autism - linked gene stunts developing dendrites: Genetic variation leads to excessive pruning of dendrites in rats cells and mouse model of autism.»

Using a variation of CRISPR, gene editing may be a potential strategy for mimicking the protective effects of a genetic mutation linked to heart disease.

Successful behavioral adaptation to habitat is fundamentally important to species fitness, but linking such behaviors to genes has proven difficult due to plasticity of phenotypes and rarity of within - species genetic variation underlying adaptive behavioral patterns.

After looking at 9 million genetic variants in those who were asparagus anosmic, they linked this deficiency to 871 individual sequence variations they discovered in chromosome 1, on genes associated with our sense of smell.

That can make it hard to make subtle changes to a gene — like introduce point mutations corresponding to natural variations linked with human disease — without taking a sledgehammer to the entire gene locus.

Dozens, even hundreds, of potential gene variations have been linked to the diseases.

They found that individuals with genetic variations to the RASGRF2 gene had higher activation of the ventral striatum area of the brain (closely linked to the VTA and involved in dopamine release) when anticipating reward in a cognitive task.

Forms of variation include single DNA base pair alterations, duplications or deletions of genes or sets of genes, and translocations, a chromosomal rearrangement in which a segment of genetic material from one chromosome becomes heritably linked to another chromosome.

Next, Dr. Wildin reviews basic genetic terminology, including genes / gene structure, genotype, phenotype, penetrance, expressivity, inheritance, variation, mutation types, and how genes are linked to disease.

Genetic variation in HDAC4 among the women was linked to a lower level of HDAC4 gene activity and differences in their ability to respond to and recover from fear, and also differences in «resting state» brain imaging.

Other uses of having a known link between multiple DNA sequencing reads includes studies of structural variations in for instance cancer cells, and when linking functional genes to taxonomic groups in microbial communities.

For genetic screenings in a clinical setting it could for instance enable to correctly assign critical genetic variations in disease - linked genes.

deCODE selected EP3 as a target in PAOD through its population genetics research, which linked variations in the gene encoding EP3 to increased risk of the disease.

The link was strongest in women who had the APOE4 gene, a genetic variation that increases the risk for Alzheimer's disease.

Researchers have identified over 100 genetic variations linked to lupus but no gene or combination that directly causes it.

The increased power provided by looking for specific gene candidate variations rather than linked markers will aid the identification of epilepsy risk factors, perhaps leading to development of DNA tests to enable breeders to select against such risk factors.

Socio - economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene - linked polymorphic region

This investigation examined the extent to which polymorphisms of the serotonin transporter linked promoter region (5 - HTTLPR) and the dopamine receptor D4 (DRD4) genes differentially influenced the development of attachment security and disorganization in maltreated and nonmaltreated infants at age 13 months, and the extent to which the efficacy of preventive interventions to promote attachment security were influenced by genetic variation.

Allele association studies have linked the 48 bp repeat polymorphism of the DRD4 gene with normal variations of neonatal, infant, and adult temperament [85], but also with clinical hyperactivity (ADHD)[93, 94].

The 5 - HT transporter gene - linked polymorphic region (5 - HTTLPR) in evolutionary perspective: Alternative biallelic variation in rhesus monkeys

Related to this question, recent research suggests that particular polymorphisms, often those linked to risk for pathology, make the individual more susceptible to be influenced by parenting and other experiences.24 - 26 For example, children carrying the 7 - repeat variation of the DRD4 appear to benefit more from interventions directed to prevent behaviour problems than those carrying other variations of the gene.24 Nonetheless, further research is needed on how and to what extent EC skills may be influenced by the interplay between constitution and experience.