Sentences with phrase «gene variations associated»

Pulling up a grid with my results, Mattingly says that in this case, I came out normal in my genetic profile for gene variations associated with mercury sensitivity.

«Opioid receptor gene variations associated with neonatal abstinence syndrome severity.»

Not exact matches

This massive dataset is a powerful resource for understanding natural genetic variation in rice as well as for large - scale discovery of new genes associated with economically important traits.

Other research shows that ADHD children with a particular gene variation have thinner tissue in the area of the brain that's associated with attention.

Genetic variations most strongly associated with high scores were found near the GATA2 gene — involved in the development of inner ear hair cells and the inferior colliculus.

«Identifying which of these candidate genes actually causes variation in responses to cold snaps will give us the potential to understand whether evolution to climate change can occur in both wild and domesticated animals, allowing us to better predict which species or breeds will be «winners» and «losers» and to better mitigate the effects of anthropogenic climate change on a wide range of organisms from beneficial pollinators to invasive pests,» said Theodore Morgan an associate professor of evolutionary genetics in the Division of Biology at Kansas State University and senior author of the study.

To find other genes associated with these traits, researchers will need to scan the genomes of even more women and look for less common genetic variations, says Kári Stefánsson, CEO of deCODE Genetics in Reykjavik, Iceland.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

Researchers at Moffitt Cancer Center hope to improve NSCLC patient survival with the results of a study that found that inherited genetic variations in interleukin genes are associated with improved patient survival and response to therapy.

Not long after the HD gene was isolated, studies led by MacDonald, also a co-author of the current investigation, found that a variation in the number of CAG trinucleotide repeats within the HD gene, which codes for a protein called huntingtin, is the primary determinant of the age at which HD symptoms appear, with a greater number of CAG repeats associated with an earlier symptom onset.

Arbuthnott wants to investigate variation in females and what genes are associated with attractive traits.

Variation in pigmentation among human populations may reflect local adaptation to regional light environments, because dark skin is more photoprotective, whereas pale skin aids the production of vitamin D. Although genes associated with skin pigmentation have been identified in European populations, little is known about the genetic basis of skin pigmentation in Africans.

A new study led by researchers at Boston Medical Center (BMC) indicates that variations in opioid receptor genes are associated with more severe neonatal abstinence syndrome (NAS) in newborn babies.

The international team, led by Professor Jacob George and Doctor Mohammed Eslam at the Westmead Institute, had previously identified that the common genetic variations associated with liver fibrosis were located on chromosome 19 between the IFNL3 and IFNL4 genes.

Genes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the ArGenes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Argenes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Arctic.

However, the researchers found that a variation of ECR47 associated with ADHD disrupted ECR47's ability to bind an important neurodevelopmental transcription factor, YY1 — an indication that the risk variant interferes with gene transcription.

Researchers studying two generations of a family affected by pediatric acute lymphoblastic leukemia (ALL) have identified an inherited variation in the ETV6 gene that is associated with an increased risk of developing the disease.

Previous studies have suggested, among other things, that differences in dogs» ability to communicate are associated with variations in the genetic material located close to the gene that codes for the oxytocin receptor.

However, co-expression network analysis also revealed two modules of interconnected genes that were particularly rich in genetic variations associated with bipolar disorder, suggestive of a causal role in the disorder.

Now, he and his colleagues are studying larger numbers of cave fish with variation in these behaviors, in the hopes that they can tease out which versions of which genes are associated with the extremes of these behaviors.

«While previous molecular studies have provided simple snapshots of the gene transcript variations that are associated with the exposure of insects to natural and synthetic chemicals, the genomics approaches used in this study offer a significantly more complex perspective on the biochemical and physiological processes occurring in plant - insect interactions,» Schuler said.

One of their findings was a variant in a gene called Ret that had not been previously associated with the disease, although other variations in Ret had been fingered as culprits.

Some people have a variation of that gene, called DRD2 A1, that is associated with a lower density of dopamine receptors in the brain.

Variations in the genes OPRM1, ABCB1, and COMT are associated with risk for opioid addiction in adults.

Exchange of material between this gene and a neighboring gene associated with green light leads to a high amount of genetic variation but can result in color blindness if the process goes awry.

«In addition, the depth of the MSSNG database allowed us to identify resilient individuals who carry autism - associated gene variations without developing autism.

University researchers have identified a link between injury to the developing brain and common variation in genes associated with schizophrenia and the metabolism of fat.

Megelencephaly and macrocephaly genes are associated with comparative variation in primate brain size [abstract].

Variations in gut microbiota and fecal metabolic phenotype associated with Fenbendazole and Ivermectin Tablets by 16S rRNA gene sequencing and LC / MS - based metabolomics in Amur tiger — Fengping He — Biochemical and Biophysical Research Communications

After looking at 9 million genetic variants in those who were asparagus anosmic, they linked this deficiency to 871 individual sequence variations they discovered in chromosome 1, on genes associated with our sense of smell.

The study demonstrates that variations in the PDE4D gene are significantly associated with ischemic stroke.

Mariman EC, Bouwman FG, Aller EE, van Baak MA, Wang P. Extreme obesity is associated with variation in genes related to the circadian rhythm of food intake and hypothalamic signaling.

Each of the three trace amine - associated receptor genes can occur in two variations in each individual.

The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

However, this is complicated by the fact that a preponderance of disease - associated genetic variation lies outside of protein - coding genes.

Here we show variation between incompatible Culex strains in two Wolbachia ankyrin repeat - encoding genes associated with a prophage region, one of which is sex - specifically expressed in some strains, and also a direct effect of the host nuclear genome on CI rescue.

Other accomplishments in this area include the mapping of variation in the FTO gene for obesity, characterizing the role of interleukin (IL)-6, IL - 10, and IL - 1RA in obesity and insulin resistance in African Americans (AA), and determining the loci associated with CRP, IL - 10, IL - 1Ra, and IL - 6 levels in a GWAS of AA.

Exceptions included the ZFAT gene, which is associated with variation in wither height (36), for which both ancient individuals carried a mixture of reference and alternative alleles.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

The study is the first to scan virtually all of the variations in human genes to find those associated with bipolar disorder.

The team found a variation on a gene called POMC, which has been associated with human weight differences.

Our approach to identifying islands of divergence relies, in part, in levels of variation within populations and therefore is potentially sensitive to any process that reduces diversity within either subspecies, and thus high divergence may not be directly associated with signatures of reduced gene flow due to incompatibilities.

189/5: 30 Defining variation sensitive regions in genes associated with disease.

Approximately 15 genes have been directly associated with skin pigmentation variation in humans, leading to its characterization as a relatively simple trait.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

132/5: 15 Complex diseases are associated with variation in Mendelian genes: A phenome - wide study using Human Phenotype Ontology and a population genotyped on the Exome BeadChip.

Variation in this gene has been shown to be associated with melanoma risk even in patients without red hair [22], [23].

However, being a complex multistep process, cancer cytogenetics are broadened to «cytogenomics,» with complementary resources on: general databases (nucleic acid and protein sequences databases; cartography browsers: GenBank, RefSeq, UCSC, Ensembl, UniProtKB, and Entrez Gene), cancer genomic portals associated with recent international integrated programs, such as TCGA or ICGC, other fusion genes databases, array CGH databases, copy number variation databases, and mutation databases.

By characterizing the role of gene mutations and copy number variations in a number of complement associated disorders, including kidney diseases, such as HUS (Hemolytic Uremic Syndrome), DDD (Dense Deposit Disease) or AMD (Age Related Macular Degeneration) the group has identified new disease subtypes of this severe kidney diseases.

Insecticide resistance is typically associated with alterations to the insecticidal target - site or with gene expression variation at loci involved in insecticide detoxification.