Sentences with phrase «gene variations in»

The aim of this project is to investigate the role of serotonin transporter gene variations in the development and treatment of cocaine dependence.

Not exact matches

The OAR proposal uses a variation of therapeutic cloning called altered nuclear transfer (ANT) in which the nucleus of a donor cell (a skin cell, for example), containing the 30,000 genes of the genetic code, is altered in such a way that it produces an epigenetic factor, a protein called nanog.

In the case of homosexuality we potentially are talking about randomly occurring variations of a a specific gene that would seem to occur with regularity.

In this paper, I tried to interpret evolution as a continually shifting balance, spatially and temporally, among what I called the pressures of mutation, selection, and migration on gene frequencies, in conjunction with the effects of random drift composed of random variations in these pressures and of local accidents of samplinIn this paper, I tried to interpret evolution as a continually shifting balance, spatially and temporally, among what I called the pressures of mutation, selection, and migration on gene frequencies, in conjunction with the effects of random drift composed of random variations in these pressures and of local accidents of samplinin conjunction with the effects of random drift composed of random variations in these pressures and of local accidents of samplinin these pressures and of local accidents of sampling.

This massive dataset is a powerful resource for understanding natural genetic variation in rice as well as for large - scale discovery of new genes associated with economically important traits.

Other research shows that ADHD children with a particular gene variation have thinner tissue in the area of the brain that's associated with attention.

Therefore, variation in RNA quality across lactation stage must be considered when interpreting gene expression results across postpartum time points.

In the current study, Whitney, along with colleagues John Hinson, WSU professor of psychology, and Hans Van Dongen, director of the WSU Sleep and Performance Research Center at WSU Spokane, compared how people with different variations of the DRD2 gene performed on tasks designed to test both their ability to anticipate events and their cognitive flexibility in response to changing circumstanceIn the current study, Whitney, along with colleagues John Hinson, WSU professor of psychology, and Hans Van Dongen, director of the WSU Sleep and Performance Research Center at WSU Spokane, compared how people with different variations of the DRD2 gene performed on tasks designed to test both their ability to anticipate events and their cognitive flexibility in response to changing circumstancein response to changing circumstances.

But over the past decade, researchers have identified hundreds of gene variations that seem to affect brain development in ways that increase the risk of autism.

Variations in gene activity seem to indicate when someone is considering suicide.

Lacking money to outfit the new lab, Wang and Xin bought used equipment: a single channel DNA sequencer (bought and barely touched by a Harvard Medical School researcher); second - hand centrifuges and pipettes; a reconditioned CytoScan HD system that detects variations in the number of copies of a gene.

Based on the core principles of behavioral genetics, if genetics explain variations in distrust and trust behaviors, then identical twins should behave more similarly to each other than fraternal twins, since the genes of identical twins are shared, while the genes of fraternal twins are only imperfectly correlated, Reimann said.

Genetic variations most strongly associated with high scores were found near the GATA2 gene — involved in the development of inner ear hair cells and the inferior colliculus.

«Identifying which of these candidate genes actually causes variation in responses to cold snaps will give us the potential to understand whether evolution to climate change can occur in both wild and domesticated animals, allowing us to better predict which species or breeds will be «winners» and «losers» and to better mitigate the effects of anthropogenic climate change on a wide range of organisms from beneficial pollinators to invasive pests,» said Theodore Morgan an associate professor of evolutionary genetics in the Division of Biology at Kansas State University and senior author of the study.

They made these clones by a process called automatic parthenogenesis: The egg is formed normally (with half the species» usual number of chromosomes), then fertilized by the «polar body,» a cell that is created during oogenesis and contains the same gene copies as the egg, resulting in the shark having half the genetic variation of its mother.

Although unique genetic variations in children with autism are nearly as rare as they are in the general population, comprehensive studies are starting to find patterns in disrupted genes and pathways

The scientists looked for mutations, or abnormal changes in the DNA, and filtered out normal variations in genes that commonly occur among humans.

More to the point, your health, your life span — and even some of your actions — may have more to do with the genetic variation in those microorganisms you host than they do with your own genes.

«It's sort of the tip of the iceberg,» says Uitterlinden, who led one of four groups that identified several variations in a gene called LIN28B that affect the timing of girls» first period, or menarche.

The study found that in the 18th and 19th centuries, about four to 18 per cent of the variation between individuals in lifespan, family size and ages at first and last birth was influenced by genes, while the rest of the variation was driven by differences in various aspects of their environment.

He had noted subtle variations between the resistance genes he pulled out of soil organisms and their doppelgängers in disease - causing bacteria.

To find other genes associated with these traits, researchers will need to scan the genomes of even more women and look for less common genetic variations, says Kári Stefánsson, CEO of deCODE Genetics in Reykjavik, Iceland.

So geneticists Stephen O'Rahilly and Sadaf Farooqi at the University of Cambridge, and colleagues, turned to a different kind of genetic variation, known as a deletion, in which entire genes are absent.

All four teams focused their hunts on gene variations found in at least 10 per cent of the population, while Stefánsson thinks that rarer variants may play a more significant role in menarche.

The team also looked at gene expression before and after exposure and identified 335 genes whose variation in expression correlated with caspase activity.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

«Within the context of our emerging appreciation of polygenic risk, where gene variations are implicated in several disorders, the new findings point to only partial overlap in the risk mechanisms for these two forms of bipolar disorder,» said Dr. Krystal.

That is, certain variations in the children's CHRM2 gene appear to interact with parental negligence to produce the most undesirable teenage behavior.

After gene - typing about 3,000 people, Sturm found that how OCA2 is expressed — and how much pigment a person has — is strongly linked to three single nucleotide polymorphisms (SNPs), or single letter variations, in a DNA sequence near the OCA2 gene.

The researchers discovered that patients who had certain genetic variations in interleukin genes had a better response to either surgery or chemotherapy, resulting in improvements in overall survival, disease - free survival and the amount of time until disease recurred.

More recently, it has become clear that slight variations in the regulatory sequences that determine when a gene is switched on,...

The researchers found that adolescents who had a variation of another gene, which contributes to how quickly serotonin is recycled in the brain and which has been linked to hostile behavior in children, were more likely to exhibit signs of psychopathy.

Researchers at Moffitt Cancer Center hope to improve NSCLC patient survival with the results of a study that found that inherited genetic variations in interleukin genes are associated with improved patient survival and response to therapy.

This gene, which controls the amount of melanin pigment produced, accounts for about 74 percent of the total variation in people's eye color.

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cookinIn a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cookinin The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cookinin the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

Next, he synthesised 50,000 DNA strands with sequences that almost matched parts of the 24 genes involved in lycopene production, but with a range of variations that he hoped would affect the amount of lycopene produced.

Moffitt researchers focused their attention on inherited genetic variations in genes called interleukins.

Brin writes on his blog that the genome scan of his saliva from 23andMe told him he has a mutation on the LRRK2 gene, a variation called G2019S, which ups the risk for Parkinson's in some families.

For example, individuals with variations in a gene called FTO tend to desire high - calorie foods more often and have more fat as a result.

One variation of the IRS1 gene caused lower fat in men.

In the current work, they used a new variation of the gene - editing system to repair the defect in both a mouse model and in human cellIn the current work, they used a new variation of the gene - editing system to repair the defect in both a mouse model and in human cellin both a mouse model and in human cellin human cells.

Scientists have found a variation of the miR - 182 gene in patients with primary open - angle glaucoma that results in this overexpression, said Dr. Yutao Liu, vision scientist and human geneticist in the Department of Cellular Biology and Anatomy at the Medical College of Georgia at Augusta University.

From this research, Loos found that fatness was significantly linked to variations in the FTO gene and a gene called IRS1.

Harvard Medical School researcher Melina Claussnitzer and her team found that a single variation in the FTO gene caused fat cells that would normally become healthier beige to turn into white fat cells instead.

To find out whether they had evolved to cope, Andres Moreno at Stanford University in California and colleagues looked at the variation of a gene known to be involved in water retention in the kidney, called FOXI1, in DNA samples from 20 Europeans, 20 east Asians and 20 Yoruba.

The researchers measured heritability — the amount of variation in a characteristic that can be attributed to genes — for a wide variety of human traits including blood pressure, the structure of the eyeball and mental or behavioral disorders.

Further experiments showed that variations in the genes led to observable changes in cellular dynamics.

Trent and others says that the same mechanism might be at work in genes linked to other cancers, such as breast and prostate cancer, which have been found to contain similar «harmless» sequence variations.

Not long after the HD gene was isolated, studies led by MacDonald, also a co-author of the current investigation, found that a variation in the number of CAG trinucleotide repeats within the HD gene, which codes for a protein called huntingtin, is the primary determinant of the age at which HD symptoms appear, with a greater number of CAG repeats associated with an earlier symptom onset.

They compared each individual's lifespan to that of their relatives and their degree of separation and found that genes explained about 16 percent of the longevity variation seen in their data — on the low end of previous estimates which have ranged from about 15 percent to 30 percent.