Not exact matches
In the case of homosexuality we potentially are talking about randomly occurring
variations of a a specific
gene that would seem to occur
with regularity.
An Israeli research group found that certain
variations of the
gene made people much more likely to affirm such statements as «I bubble
with happiness» and «I am a cheerful optimist.»
In this paper, I tried to interpret evolution as a continually shifting balance, spatially and temporally, among what I called the pressures of mutation, selection, and migration on
gene frequencies, in conjunction
with the effects of random drift composed of random
variations in these pressures and of local accidents of sampling.
This massive dataset is a powerful resource for understanding natural genetic
variation in rice as well as for large - scale discovery of new
genes associated
with economically important traits.
Other research shows that ADHD children
with a particular
gene variation have thinner tissue in the area of the brain that's associated
with attention.
In the current study, Whitney, along
with colleagues John Hinson, WSU professor of psychology, and Hans Van Dongen, director of the WSU Sleep and Performance Research Center at WSU Spokane, compared how people
with different
variations of the DRD2
gene performed on tasks designed to test both their ability to anticipate events and their cognitive flexibility in response to changing circumstances.
Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial - nuclear interactions alter the frequency of alternative forms of a
gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence
variations within a population of the fish
with mixed ancestry.
Sleep - deprived people
with two other
variations of the
gene tend to perform much more poorly on the same kinds of tasks, the researchers found.
Genetic
variations most strongly associated
with high scores were found near the GATA2
gene — involved in the development of inner ear hair cells and the inferior colliculus.
They made these clones by a process called automatic parthenogenesis: The egg is formed normally (
with half the species» usual number of chromosomes), then fertilized by the «polar body,» a cell that is created during oogenesis and contains the same
gene copies as the egg, resulting in the shark having half the genetic
variation of its mother.
Our genomes are strewn
with millions of rare
gene variations, the result of the very fast, very recent population growth of the human species.
Although unique genetic
variations in children
with autism are nearly as rare as they are in the general population, comprehensive studies are starting to find patterns in disrupted
genes and pathways
More to the point, your health, your life span — and even some of your actions — may have more to do
with the genetic
variation in those microorganisms you host than they do
with your own
genes.
To find other
genes associated
with these traits, researchers will need to scan the genomes of even more women and look for less common genetic
variations, says Kári Stefánsson, CEO of deCODE Genetics in Reykjavik, Iceland.
The team also looked at
gene expression before and after exposure and identified 335
genes whose
variation in expression correlated
with caspase activity.
We have identified hundreds of genetic
variations associated
with autoimmune diseases that appear to affect the activity of
genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable
with medication.»
The researchers identified at least five
variations whose correlation
with a certain disease depended on whether the
gene is maternal or paternal.
That is, certain
variations in the children's CHRM2
gene appear to interact
with parental negligence to produce the most undesirable teenage behavior.
Researchers at Moffitt Cancer Center hope to improve NSCLC patient survival
with the results of a study that found that inherited genetic
variations in interleukin
genes are associated
with improved patient survival and response to therapy.
In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both
with copy number
variation of the salivary amylase
genes and controlled fire use for cooking.
Next, he synthesised 50,000 DNA strands
with sequences that almost matched parts of the 24
genes involved in lycopene production, but
with a range of
variations that he hoped would affect the amount of lycopene produced.
For example, individuals
with variations in a
gene called FTO tend to desire high - calorie foods more often and have more fat as a result.
Scientists have found a
variation of the miR - 182
gene in patients
with primary open - angle glaucoma that results in this overexpression, said Dr. Yutao Liu, vision scientist and human geneticist in the Department of Cellular Biology and Anatomy at the Medical College of Georgia at Augusta University.
Not long after the HD
gene was isolated, studies led by MacDonald, also a co-author of the current investigation, found that a
variation in the number of CAG trinucleotide repeats within the HD
gene, which codes for a protein called huntingtin, is the primary determinant of the age at which HD symptoms appear,
with a greater number of CAG repeats associated
with an earlier symptom onset.
Overall, these twin studies suggest that
genes explain between 30 and 60 percent of altruistic tendencies,
with the remaining
variation coming from cultural or social effects.
Arbuthnott wants to investigate
variation in females and what
genes are associated
with attractive traits.
Individuals who had a particular
variation in a specific
gene (platelet derived growth factor D; PDGFD) had a markedly increased risk of adrenal suppression, both in the children
with asthma and adults
with COPD.
Variation in pigmentation among human populations may reflect local adaptation to regional light environments, because dark skin is more photoprotective, whereas pale skin aids the production of vitamin D. Although
genes associated
with skin pigmentation have been identified in European populations, little is known about the genetic basis of skin pigmentation in Africans.
Researchers looked for regions of each plant's genome that showed unusual patterns of
variation consistent
with past selective breeding acting on the VRN - D4
gene.
Such high levels of genetic
variation poise mosquito populations to rapidly evolve in response to our efforts to control them whether that be
with insecticides or any other control measure, including
gene drive.»
«Opioid receptor
gene variations associated
with neonatal abstinence syndrome severity.»
They found men
with a specific
variation in the well - known TCF4
gene have a higher risk of disease, while women
with variations in one of the newly identified
genes, LAMC1, have an increased risk.
A new study led by researchers at Boston Medical Center (BMC) indicates that
variations in opioid receptor
genes are associated
with more severe neonatal abstinence syndrome (NAS) in newborn babies.
The international team, led by Professor Jacob George and Doctor Mohammed Eslam at the Westmead Institute, had previously identified that the common genetic
variations associated
with liver fibrosis were located on chromosome 19 between the IFNL3 and IFNL4
genes.
Previous work had shown that two
variations in the COX - 2
gene,
with either a guanine (G) or a cytosine (C) molecule at a particular spot in the
gene's DNA sequence, lead to different levels of COX - 2 protein.
With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect
gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune
genes and genetic networks that play roles in vaccine response.
Researchers report that one tiny
variation in the sequence of a
gene may cause some people to be more impaired by traumatic brain injury (TBI) than others
with comparable wounds.
People
with a specific
variation in the CLOCK
gene have more migraines under financial stress.
Genes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Ar
Genes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including
genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Ar
genes associated
with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal
variations in day length in the Arctic.
And some women
with the
variation are spared as well, depending on whether they received the
gene from their mothers or their fathers.
To find out how DISC1 acts on synapses, the researchers also compared the activity levels of
genes in the healthy neurons to those
with the
variation.
However, the researchers found that a
variation of ECR47 associated
with ADHD disrupted ECR47's ability to bind an important neurodevelopmental transcription factor, YY1 — an indication that the risk variant interferes
with gene transcription.
Researchers studying two generations of a family affected by pediatric acute lymphoblastic leukemia (ALL) have identified an inherited
variation in the ETV6
gene that is associated
with an increased risk of developing the disease.
The
gene copies also hide natural
variation in the wheat genome that could create opportunities to selectively breed plants
with useful traits.
Although previous research has identified
genes involved
with behaviors seen in eating disorders such as anorexia or bulimia, little is known about how natural
variation in these
genes could affect eating behaviors in healthy people.
Researchers have discovered that protection from the most severe form of malaria is linked
with natural
variation in human red blood cell
genes.
Further analysis revealed that a single - letter change in the
gene accounted for 46 per cent of the population's hair colour
variation,
with the blonde allele being recessive to the dark hair allele.
Patients
with a particular inherited
variation in the
gene IFITM3 were more than twice as likely to develop severe, life - threatening flu symptoms as those who carried the protective version of the
gene.
Mutations affecting adult haemoglobin production are among the most common of all genetic
variations,
with about 5 per cent of the world's population carrying a defective
gene.
So geneticists have been focusing on the dog as a possible model for
gene searches because this lack of sequence
variation may help them circumvent a frequent problem
with studies in humans.