First based on our completed genetic study we will test if pharmacological inhibition of an identified protein
via direct eye
injection can promote long distance optic nerve regeneration or whether, based on strong preliminary data, manipulation of another novel
gene can induce such regeneration.
The lab has generated «floxed» alleles of GABAA receptor subunit
genes that allow us to ablate the respective subunit in a subregion specific manner — e.g., in hippocampal subregions or the amygdala — either
via a cross with cre - transgenic mice or
via stereotaxic
injection of cre - expressing viruses into defined brain regions.