Sentences with phrase «generalised lipodystrophy»

Conclusions: Our findings demonstrate that disruption of Bscl2 specifically in developing adipocytes is sufficient to cause the early - onset generalised lipodystrophy observed in patients with mutations in BSCL2.

Objective: Mutations to the BSCL2 gene disrupt the protein seipin and cause the most severe form of congenital generalised lipodystrophy (CGL).

Adipose specific disruption of seipin causes early - onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease