This product was recently evaluated as a topical treatment for
generalized demodicosis in a small study
involving 16 dogs older than 1 year of age.16 Dogs were divided into two equal groups and treated with the spot - on at the proposed minimum dose rate (20 mg / kg of both metaflumizone and amitraz, 0.133 ml / kg) on days 0, 28, and 56 or days 0, 14, 28, 42, 56, and 70.