Spinal muscular atrophy (SMA) is an inherited disease characterized by the selective death of motor neurons, resulting
in generalized muscle weakness that is often fatal in infancy or early childhood.
However, the defect in the communication channels between their nerves and skeletal muscles causes dogs with myasthenia gravis to
suffer generalized muscle weakness, which is made worse with activity or exercise.
In the present seminar, I will present (i) how these gene mutations lead to
generalized muscle weakness and (ii) the advances regarding potential therapies.
If there is excessive loss of potassium this can lead to
generalized muscle weakness, paralytic ileus, and even cardiac arrhythmias which can adversely affect the delivery of oxygen and nutrients to the cells.
This helps resolve
the generalized muscle weakness that almost always is associated with myasthenia gravis.