Sentences with phrase «generate gene knockouts»
Not exact matches
The FAN1 knockout mice that Smogorzewska's lab has generated allow them to investigate the role of FAN1 in DNA repair, and to figure out how mutations in the gene may lead to kidney disease.
https://www.sciencedaily.com/
Kohli, Manu, et al. «Facile methods for generating human somatic cell gene knockouts using recombinant adeno ‐ associated viruses.»
The goal of the International Mouse Phenotyping Consortium (IMPC) is to discover functional insight for every gene by generating and systematically phenotyping 20,000 knockout mouse strains.
The IMPC is generating a knockout mouse strain for every protein coding gene by using the embryonic stem cell resource generated by the International Knockout Mouse Consortiumknockout mouse strain for every protein coding gene by using the embryonic stem cell resource generated by the International Knockout Mouse ConsortiumKnockout Mouse Consortium (IKMC).
From 2012 onwards the IMPC is continuing the task to generate knockout mice and phenotype the remainder of the 20,000 plus genes in a worldwide coordinated initiative.
In Aim 1, we generate cell specific - knockout mice and characterize deletion of expression of distinct genes relevant to axon guidance.
The Knockout Mouse Project (KOMP & KOMP2) is a trans - NIH initiative that aims to generate a comprehensive and public resource comprised of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome.
Using CRISPR / Cas9 technology, we generated biallelic knockout mutations in host genes encoding IRF5 and IL - 10RA in iPSCs, and confirmed their roles in limiting chlamydial infection in macrophages.
The Mouse Core (G) targeted multiple associated genes to generate a collection of knockout and conditional knockout mutant models.