Sentences with phrase «generate germ line»

Not exact matches

Deep sequencing analysis has shown that this is highly unlikely in the case of J3 as no sequences were generated by deep sequencing of the seven naïve llamas or three other immunized llamas that share greater identity with J3 than its putative germ line V gene.

This must be accomplished by using a process known as germ - line transmission, where the primordial germ cells (PGCs) of an early embryo are edited, grown in cultures, and then reproductively transmitted through surrogate host parents to generate live, engineered birds.

J, Hematoxylin and eosin staining of teratoma sections generated from integration - free iPSC lines showing differentiation in three germ layers: goblet cells in gastro - intestinal (GI) tract (endoderm); neural rosettes (ectoderm) and blood vessels, muscle and cartilage / bone (mesoderm).

EMMA strains produced from ES cells generated by the International Knockout Mouse Consortium (IKMC) are displayed on the EMMA strain list as soon as germ - line transmission has been achieved and the genotype of the pups has been confirmed.

His pioneering mouse embryonic stem (ES) cell work in the 1980s, demonstrating germ - line transmission and the great potential of ES cells to generate mice carrying mutations in endogenous genes, established milestones in a field that saw the award of the 2007 Nobel Prize in Physiology or Medicine to Mario Capecchi, Martin Evans, and Oliver Smithies.

We have recently generated mice with germ - line knockout (KO) of Melk.