Sentences with phrase «generate immune responses»

They are also designed to produce proteins that physically resemble actual HIV proteins so that they will generate immune responses more like those seen in response to a real HIV infection.

Many triggers can generate immune responses, such as infections, stress, illness, or allergies.

Exposure to everyday pathogens generates an immune response that could interfere with CRISPR - based gene - editing treatment

Activated T cells, which have been exposed to a particular antigen, are more sensitive and generate an immune response to that antigen more quickly and aggressively than naive T cells.

To confirm that the missing mutations were important for generating an immune response, the researchers cultured a subset of the neoantigen protein fragments containing the tumor mutations with immune cells taken from three patients» blood samples.

In clinical trials, several candidate H7N9 pandemic influenza vaccines made from inactivated viruses have been shown to be safe and to generate an immune response.

These bacteria, once in the general circulation of the body, may be considered harmful, and the body generates an immune response.

A second hurdle in cancer is to generate an immune response sharply focused on cancer cells while avoiding normal cells and tissues.

The goals of Phase II trials are usually to learn more about vaccine safety and to see if the vaccine generates an immune response.

Many antibodies are currently used in cancer treatment, and some appear to generate an immune response.

Many monoclonal antibodies are currently used in cancer treatment, and some appear to generate an immune response.

A preclinical study in mice, published earlier this week in Nature, showed that a single dose of ZPIV generated an immune response, which protected the mice against subsequent Zika challenge with a Brazilian strain of the virus.

The proteins generate an immune response within the human body that scientists had once hoped would resemble the immune response generated by HIV itself.

Researchers found the tumors that had PTEN loss were less likely to generate an immune response than tumors that maintain PTEN levels.

«We have created a potentially much less expensive approach to making a therapeutic cancer vaccine that, while targeting a single tumor antigen, generates an immune response against multiple antigens.

He explains that heat makes cancer cells look distinct from healthy cells, thereby generating an immune response that is both immediate and long - lasting.

If you plan on boarding your dog, check with your veterinary office for their recommendations on when to schedule the vaccination, as it may take about five days for your dog to generate an immune response from the vaccine in order to provide the needed protection.

The pet has the disease but is unable to generate an immune response because it is immunosuppressed.

Not exact matches

The company is developing a T - cell reprogramming technology designed to generate an anti-tumor response from the patient's own immune system.

The researchers found that the immune cells in the skin of this animal model generated large amounts of the cytokine IL - 17 — a protein of the immune system that activates cellular inflammation in response to damage.

When the team compared the types of immune cells activated in the fetus with those in the mother, there were clear differences, suggesting that fetuses generate an independent immune response to CMV (Journal of Experimental Medicine, DOI: 10.1084 / jem.20090348).

And before they expired, the bacteria generated a protective immune response in the animals.

In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.

To improve on this result, the researchers used recombinant DNA techniques to generate purified recombinant proteins from the designed multiepitope DNA strings, and gave the mice a series of protein booster shots to increase their immune response.

«But it's the part that generates the strongest response from the immune system.»

They serve to contain viral infections while the adaptive immune response is generating antigen - specific cytotoxic T cells that can clear the infection.

The team found that mice lacking CTCF were incapable of generating germinal centers during the immune response.

A combination of iron - oxide nanoparticles and an alternating magnetic field, which together generate heat, have activated an immune system response to tumors in mice according to an accepted manuscript by Dartmouth - Hitchcock Norris Cotton Center researchers in the journal Nanomedicine: Nanotechnology, Biology and Medicine released online on February 24, 2014.

The albumin - targeted vaccines provoked immune responses five to 10 times stronger than those generated by the peptide antigens alone.

The immediate goal, she says, is not just to decipher the mechanics of immune system activation, but to stratify TB proteins based on the strength of the immune response each generates.

«We're able to shuttle millions of cells through this device, generating a very potent immune response against the cancer cells,» Mooney says.

Animals treated on day 3 following infection showed no evidence of virus in the blood and did not generate any SIV - specific immune responses.

When injected into mice that were then given a subsequent injection of lymphoma cells, the 3D vaccine generated a potent immune response and delayed tumor growth.

The nanoparticle, the vector for IL - 2, carries the substance to the receptors in cancer cells, then saturates them and kills them, besides generating an immune T cells bridge (in charge of activating the immune response of the organism).

Up until now, efforts in generating a vaccine against TB have been mainly focused on T cells (cells from the adaptive arm of our immune response with memory capacity), with very disappointing outcomes in both pre-clinical as well as clinical trials.

T CD4 + cells are crucially important in generating protective cell immune responses and they are thought to be deregulated in multiple sclerosis.

The study characterized the immune responses generated by vaccination against Ebola delivered to the respiratory tract as either an aerosol or liquid.

The main change, a point mutation in the human gene for hu14.18, was designed to address treatment - limiting pain by generating a more tailored response that avoided triggering part of the immune response called the complement cascade.

Tissue - resident memory cells generate an alert state that attracts and reactivates the circulating memory cells, resulting in a faster and more effective immune response.»

Removing the cytoplasmic domain may distract the immune response and instead generate antibodies that target epitopes on Env that would not lead to protection.

Finally, third, changes in host pathology that can relate either to adverse effects generated by the invading microbe or indeed the host immune response itself [5].

«Increased coagulation could have helped our ancestors cope with new pathogens encountered in new environments by sealing wounds more quickly and generating a faster immune response,» Capra said.

The discovery involves generating a type of naturally occurring immune cell that sends a signal to reverse the hyper - immune response present in allergic reactions.

The malarial genes under the most intense selection pressure — those with the most variation, generated over a millennium - long cat - and - mouse game with the immune system's antibody response — are the ones that encode the identifying proteins on the surface of the parasite.

When cell activity is depressed, the immune system is not generating appropriate responses to threats.

Using transplantable tumor models expressing antigen in an inducible manner or spontaneous tumor models expressing nominal antigens, we try to decipher whether the tumor is ignored or leads to deletion, anergy or class switch of the specific immune response or generate suppressor T cells.

The researchers plan to intensively study the immune responses generated by therapeutic vaccines, broadly neutralizing antibodies, and latency reversing agents in both acutely infected individuals and also in preclinical studies.

The HZI will develop a vaccination protocol for mucosal administration based on three novel strategies: (i) development and optimization of a vaccination protocol in which parenterally - primed T and B cells are subsequently pulled into the mucosa by the local delivery of the cognate antigen to the requested effector site, (ii) testing the co-administration of antigens with novel mucosal adjuvants using different mucosal immunisation routes and schedules, and (iii) testing various nanoparticles co-administered with different immunomodulators for their ability to generate both systemic and mucosal immune responses following transcutaneous / trans - follicular vaccination.

(iii) Test various nanoparticles co-administered with different immunomodulators for their ability to generate both systemic and mucosal immune responses following transcutaneous / trans - follicular vaccination.

In advanced tests not normally part of GM crop evaluations, protein produced by GM peas has generated a dangerous immune response in mice.