While much recent research has not been published in this area, there is actually a long history of studies that show: (1) there is a significant number of antigens shared between tumors and embryonic tissues (called «oncofetal antigens») and, consequently, antibodies made
against tumors can also recognize embryonic tissues, and vice versa; (2) pregnancy confers some immunity
against cancer (accompanied by antibody production
against oncofetal antigens), not only
against its occurrence but also
against its growth; (3) similar to pregnancy, an
immune response against cancer can be
generated by vaccinating animals with embryonic tissues.
«We have created a potentially much less expensive approach to making a therapeutic
cancer vaccine that, while targeting a single tumor antigen,
generates an
immune response against multiple antigens.
It is Dr. Chou's hope that, by treating colon
cancer stem cells with DAC and then exposing them to
immune cells that have been primed to recognize NY - ESO - 1, he can
generate a targeted and durable
immune response against these cells without harming healthy cells.