Sentences with phrase «generate mouse models of human disease»
Not exact matches
Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.
http://discovermagazine.com/
Historically, researchers have generated their own lines of knockout mice to serve as models for human disease, such as heart disease or cancer.
She works under the direct supervision of Dr. Lamba to conduct research to develop strategies to restore vision in mouse models generated to mimic human retinal degeneration diseases.
Numerous mouse models have been generated to examine the pathogenesis of the disease and to evaluate therapeutic approaches, but the most precise genetic reproductions of the human condition are the knock - in (KI) mouse models which express the huntingtin mutation in the proper genetic and protein context on the murine gene.